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• W2167290154 startingPage "949" @default.
• W2167290154 abstract "The attachment of microtubule plus ends to kinetochores and to the cell cortex is essential for the fidelity of chromosome segregation. Here, we characterize the causes underlying the high rates of chromosome instability (CIN+) observed in colorectal tumor cells. We show that CIN+ tumor cells exhibit inefficient microtubule plus-end attachments during mitosis, accompanied by impairment of chromosome alignment in metaphase. The mitotic abnormalities associated with CIN+ tumor cells correlated with status of adenomatous polyposis coli (APC). Importantly, we have shown that a single truncating mutation in APC, similar to mutations found in tumor cells, acts dominantly to interfere with microtubule plus-end attachments and to cause a dramatic increase in mitotic abnormalities. We propose that APC functions to modulate microtubule plus-end attachments during mitosis, and that a single mutant APC allele predisposes cells to increased mitotic abnormalities, which may contribute to tumor progression." @default.
• W2167290154 created "2016-06-24" @default.
• W2167290154 creator A5026076230 @default.
• W2167290154 creator A5042534789 @default.
• W2167290154 date "2003-12-08" @default.
• W2167290154 modified "2023-10-13" @default.
• W2167290154 title "Chromosome instability in colorectal tumor cells is associated with defects in microtubule plus-end attachments caused by a dominant mutation in APC" @default.
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• W2167290154 doi "https://doi.org/10.1083/jcb.200307070" @default.
• W2167290154 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2173599" @default.
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• W2167290154 hasPublicationYear "2003" @default.
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