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• W2167300924 abstract "The gene expression pattern specified by an animal regulatory sequence is generally viewed as arising from the particular arrangement of transcription factor binding sites it contains. However, we demonstrate here that regulatory sequences whose binding sites have been almost completely rearranged can still produce identical outputs. We sequenced the even-skipped locus from six species of scavenger flies (Sepsidae) that are highly diverged from the model species Drosophila melanogaster, but share its basic patterns of developmental gene expression. Although there is little sequence similarity between the sepsid eve enhancers and their well-characterized D. melanogaster counterparts, the sepsid and Drosophila enhancers drive nearly identical expression patterns in transgenic D. melanogaster embryos. We conclude that the molecular machinery that connects regulatory sequences to the transcription apparatus is more flexible than previously appreciated. In exploring this diverse collection of sequences to identify the shared features that account for their similar functions, we found a small number of short (20-30 bp) sequences nearly perfectly conserved among the species. These highly conserved sequences are strongly enriched for pairs of overlapping or adjacent binding sites. Together, these observations suggest that the local arrangement of binding sites relative to each other is more important than their overall arrangement into larger units of cis-regulatory function." @default.
• W2167300924 created "2016-06-24" @default.
• W2167300924 creator A5006874415 @default.
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• W2167300924 creator A5068063822 @default.
• W2167300924 date "2008-06-27" @default.
• W2167300924 modified "2023-10-07" @default.
• W2167300924 title "Sepsid even-skipped Enhancers Are Functionally Conserved in Drosophila Despite Lack of Sequence Conservation" @default.
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• W2167300924 doi "https://doi.org/10.1371/journal.pgen.1000106" @default.
• W2167300924 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2430619" @default.
• W2167300924 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18584029" @default.
• W2167300924 hasPublicationYear "2008" @default.
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