FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2167309932> ?p ?o ?g. }

• W2167309932 endingPage "532" @default.
• W2167309932 startingPage "523" @default.
• W2167309932 abstract "Cadherin-mediated adhesion depends on the association of its cytoplasmic domain with the actin-containing cytoskeleton. This interaction is mediated by a group of cytoplasmic proteins: α-and β- or γ- catenin. Phosphorylation of β-catenin on tyrosine residues plays a role in controlling this association and, therefore, cadherin function. Previous work from our laboratory suggested that a nonreceptor protein tyrosine phosphatase, bound to the cytoplasmic domain of N-cadherin, is responsible for removing tyrosine-bound phosphate residues from β-catenin, thus maintaining the cadherin–actin connection (Balsamo et al., 1996). Here we report the molecular cloning of the cadherin-associated tyrosine phosphatase and identify it as PTP1B. To definitively establish a causal relationship between the function of cadherin-bound PTP1B and cadherin-mediated adhesion, we tested the effect of expressing a catalytically inactive form of PTP1B in L cells constitutively expressing N-cadherin. We find that expression of the catalytically inactive PTP1B results in reduced cadherin-mediated adhesion. Furthermore, cadherin is uncoupled from its association with actin, and β-catenin shows increased phosphorylation on tyrosine residues when compared with parental cells or cells transfected with the wild-type PTP1B. Both the transfected wild-type and the mutant PTP1B are found associated with N-cadherin, and recombinant mutant PTP1B binds to N-cadherin in vitro, indicating that the catalytically inactive form acts as a dominant negative, displacing endogenous PTP1B, and rendering cadherin nonfunctional. Our results demonstrate a role for PTP1B in regulating cadherin-mediated cell adhesion." @default.
• W2167309932 created "2016-06-24" @default.
• W2167309932 creator A5022696053 @default.
• W2167309932 creator A5030986126 @default.
• W2167309932 creator A5053725552 @default.
• W2167309932 creator A5073844142 @default.
• W2167309932 date "1998-10-19" @default.
• W2167309932 modified "2023-10-16" @default.
• W2167309932 title "The Nonreceptor Protein Tyrosine Phosphatase PTP1B Binds to the Cytoplasmic Domain of N-Cadherin and Regulates the Cadherin–Actin Linkage" @default.
• W2167309932 cites W1042834149 @default.
• W2167309932 cites W1487264337 @default.
• W2167309932 cites W1487366060 @default.
• W2167309932 cites W1510900532 @default.
• W2167309932 cites W1527739697 @default.
• W2167309932 cites W1534652806 @default.
• W2167309932 cites W1836212818 @default.
• W2167309932 cites W1910399711 @default.
• W2167309932 cites W1973131553 @default.
• W2167309932 cites W1973524445 @default.
• W2167309932 cites W1975373701 @default.
• W2167309932 cites W1980523883 @default.
• W2167309932 cites W1984835340 @default.
• W2167309932 cites W1992267627 @default.
• W2167309932 cites W1996223704 @default.
• W2167309932 cites W1999758837 @default.
• W2167309932 cites W2003231725 @default.
• W2167309932 cites W2004755427 @default.
• W2167309932 cites W2005305957 @default.
• W2167309932 cites W2013355944 @default.
• W2167309932 cites W2014694962 @default.
• W2167309932 cites W2018471228 @default.
• W2167309932 cites W2021766527 @default.
• W2167309932 cites W2023618495 @default.
• W2167309932 cites W2025949809 @default.
• W2167309932 cites W2027980005 @default.
• W2167309932 cites W2032345748 @default.
• W2167309932 cites W2033401875 @default.
• W2167309932 cites W2035791207 @default.
• W2167309932 cites W2053544216 @default.
• W2167309932 cites W2054575721 @default.
• W2167309932 cites W2055354269 @default.
• W2167309932 cites W2059193815 @default.
• W2167309932 cites W2073885973 @default.
• W2167309932 cites W2082777494 @default.
• W2167309932 cites W2101435003 @default.
• W2167309932 cites W2102298903 @default.
• W2167309932 cites W2114329786 @default.
• W2167309932 cites W2116615268 @default.
• W2167309932 cites W2119593627 @default.
• W2167309932 cites W2119609292 @default.
• W2167309932 cites W2122829982 @default.
• W2167309932 cites W2124499018 @default.
• W2167309932 cites W2130837149 @default.
• W2167309932 cites W2143646667 @default.
• W2167309932 cites W2143902279 @default.
• W2167309932 cites W2146934540 @default.
• W2167309932 cites W2150630317 @default.
• W2167309932 cites W2159102915 @default.
• W2167309932 cites W2164240843 @default.
• W2167309932 cites W2172172421 @default.
• W2167309932 cites W3059118 @default.
• W2167309932 doi "https://doi.org/10.1083/jcb.143.2.523" @default.
• W2167309932 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2132848" @default.
• W2167309932 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9786960" @default.
• W2167309932 hasPublicationYear "1998" @default.
• W2167309932 type Work @default.
• W2167309932 sameAs 2167309932 @default.
• W2167309932 citedByCount "161" @default.
• W2167309932 countsByYear W21673099322012 @default.
• W2167309932 countsByYear W21673099322013 @default.
• W2167309932 countsByYear W21673099322014 @default.
• W2167309932 countsByYear W21673099322015 @default.
• W2167309932 countsByYear W21673099322016 @default.
• W2167309932 countsByYear W21673099322017 @default.
• W2167309932 countsByYear W21673099322018 @default.
• W2167309932 countsByYear W21673099322019 @default.
• W2167309932 countsByYear W21673099322021 @default.
• W2167309932 countsByYear W21673099322022 @default.
• W2167309932 countsByYear W21673099322023 @default.
• W2167309932 crossrefType "journal-article" @default.
• W2167309932 hasAuthorship W2167309932A5022696053 @default.
• W2167309932 hasAuthorship W2167309932A5030986126 @default.
• W2167309932 hasAuthorship W2167309932A5053725552 @default.
• W2167309932 hasAuthorship W2167309932A5073844142 @default.
• W2167309932 hasBestOaLocation W21673099321 @default.
• W2167309932 hasConcept C104317684 @default.
• W2167309932 hasConcept C108636557 @default.
• W2167309932 hasConcept C11960822 @default.
• W2167309932 hasConcept C125705527 @default.
• W2167309932 hasConcept C137620995 @default.
• W2167309932 hasConcept C142669718 @default.
• W2167309932 hasConcept C1491633281 @default.
• W2167309932 hasConcept C149402561 @default.
• W2167309932 hasConcept C153911025 @default.
• W2167309932 hasConcept C190062978 @default.
• W2167309932 hasConcept C2776165026 @default.
• W2167309932 hasConcept C2777553839 @default.
• W2167309932 hasConcept C2993400109 @default.

• next