FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2167320797> ?p ?o ?g. }

• W2167320797 endingPage "329" @default.
• W2167320797 startingPage "323" @default.
• W2167320797 abstract "Patients with sickle-cell anemia submitted to frequent blood transfusions are at risk of contamination with hepatitis C virus (HCV). Determination of HCV RNA and genotype characterization are parameters that are relevant for the treatment of the viral infection. The objective of the present study was to determine the frequency of HCV infection and the positivity for HCV RNA and to identify the HCV genotype in patients with sickle-cell anemia with a history of blood transfusion who had been treated at the Hospital of the HEMOPE Foundation. Sera from 291 patients were tested for anti-HCV antibodies by ELISA 3.0 and RIBA 3.0 Chiron and for the presence of HCV RNA by RT-PCR. HCV genotyping was performed in 19 serum samples. Forty-one of 291 patients (14.1%) were anti-HCV positive by ELISA and RIBA. Both univariate and multivariate analysis showed a greater risk of anti-HCV positivity in those who had started a transfusion regime before 1992 and received more than 10 units of blood. Thirty-four of the anti-HCV-positive patients (34/41, 82.9%) were also HCV RNA positive. Univariate analysis, used to compare HCV RNA-negative and -positive patients, did not indicate a higher risk of HCV RNA positivity for any of the variables evaluated. The genotypes identified were 1b (63%), 1a (21%) and 3a (16%). A high prevalence of HCV infection was observed in our patients with sickle-cell anemia (14.1%) compared to the population in general (3%). In the literature, the frequency of HCV infection in sickle-cell anemia ranges from 2 to 30%. The serological screening for anti-HCV at blood banks after 1992 has contributed to a better control of the dissemination of HCV infection. Because of the predominance of genotype 1, these patients belong to a group requiring special treatment, with a probable indication of new therapeutic options against HCV." @default.
• W2167320797 created "2016-06-24" @default.
• W2167320797 creator A5005813595 @default.
• W2167320797 creator A5007824818 @default.
• W2167320797 creator A5011455560 @default.
• W2167320797 creator A5022805130 @default.
• W2167320797 creator A5028955065 @default.
• W2167320797 creator A5040165666 @default.
• W2167320797 creator A5042044706 @default.
• W2167320797 creator A5047248518 @default.
• W2167320797 creator A5052372485 @default.
• W2167320797 creator A5078168021 @default.
• W2167320797 date "2003-03-01" @default.
• W2167320797 modified "2023-10-12" @default.
• W2167320797 title "Hepatitis C virus infection in a Brazilian population with sickle-cell anemia" @default.
• W2167320797 cites W1519210595 @default.
• W2167320797 cites W17739226 @default.
• W2167320797 cites W1840392281 @default.
• W2167320797 cites W1922627677 @default.
• W2167320797 cites W1972208581 @default.
• W2167320797 cites W1974879228 @default.
• W2167320797 cites W1975090758 @default.
• W2167320797 cites W1979875948 @default.
• W2167320797 cites W1988261872 @default.
• W2167320797 cites W1991378085 @default.
• W2167320797 cites W1992674405 @default.
• W2167320797 cites W2006309458 @default.
• W2167320797 cites W2010852489 @default.
• W2167320797 cites W2013383009 @default.
• W2167320797 cites W2014007838 @default.
• W2167320797 cites W2014073137 @default.
• W2167320797 cites W2023980803 @default.
• W2167320797 cites W2027319147 @default.
• W2167320797 cites W2031709733 @default.
• W2167320797 cites W2038580771 @default.
• W2167320797 cites W2040413804 @default.
• W2167320797 cites W2047480444 @default.
• W2167320797 cites W2062395204 @default.
• W2167320797 cites W2066124462 @default.
• W2167320797 cites W2081363471 @default.
• W2167320797 cites W2122494591 @default.
• W2167320797 cites W2145114883 @default.
• W2167320797 cites W2314619766 @default.
• W2167320797 cites W2341616068 @default.
• W2167320797 cites W2412079868 @default.
• W2167320797 cites W311875082 @default.
• W2167320797 cites W4302309255 @default.
• W2167320797 doi "https://doi.org/10.1590/s0100-879x2003000300006" @default.
• W2167320797 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12640496" @default.
• W2167320797 hasPublicationYear "2003" @default.
• W2167320797 type Work @default.
• W2167320797 sameAs 2167320797 @default.
• W2167320797 citedByCount "20" @default.
• W2167320797 countsByYear W21673207972012 @default.
• W2167320797 countsByYear W21673207972013 @default.
• W2167320797 countsByYear W21673207972014 @default.
• W2167320797 countsByYear W21673207972016 @default.
• W2167320797 countsByYear W21673207972017 @default.
• W2167320797 countsByYear W21673207972019 @default.
• W2167320797 countsByYear W21673207972022 @default.
• W2167320797 crossrefType "journal-article" @default.
• W2167320797 hasAuthorship W2167320797A5005813595 @default.
• W2167320797 hasAuthorship W2167320797A5007824818 @default.
• W2167320797 hasAuthorship W2167320797A5011455560 @default.
• W2167320797 hasAuthorship W2167320797A5022805130 @default.
• W2167320797 hasAuthorship W2167320797A5028955065 @default.
• W2167320797 hasAuthorship W2167320797A5040165666 @default.
• W2167320797 hasAuthorship W2167320797A5042044706 @default.
• W2167320797 hasAuthorship W2167320797A5047248518 @default.
• W2167320797 hasAuthorship W2167320797A5052372485 @default.
• W2167320797 hasAuthorship W2167320797A5078168021 @default.
• W2167320797 hasBestOaLocation W21673207971 @default.
• W2167320797 hasConcept C104317684 @default.
• W2167320797 hasConcept C126322002 @default.
• W2167320797 hasConcept C135763542 @default.
• W2167320797 hasConcept C144301174 @default.
• W2167320797 hasConcept C159047783 @default.
• W2167320797 hasConcept C203014093 @default.
• W2167320797 hasConcept C2522874641 @default.
• W2167320797 hasConcept C2776408679 @default.
• W2167320797 hasConcept C2776455275 @default.
• W2167320797 hasConcept C2777510210 @default.
• W2167320797 hasConcept C2778248108 @default.
• W2167320797 hasConcept C2778620579 @default.
• W2167320797 hasConcept C2779134260 @default.
• W2167320797 hasConcept C2780014101 @default.
• W2167320797 hasConcept C2908647359 @default.
• W2167320797 hasConcept C31467283 @default.
• W2167320797 hasConcept C38180746 @default.
• W2167320797 hasConcept C55493867 @default.
• W2167320797 hasConcept C71924100 @default.
• W2167320797 hasConcept C86803240 @default.
• W2167320797 hasConcept C90924648 @default.
• W2167320797 hasConcept C99454951 @default.
• W2167320797 hasConceptScore W2167320797C104317684 @default.
• W2167320797 hasConceptScore W2167320797C126322002 @default.
• W2167320797 hasConceptScore W2167320797C135763542 @default.
• W2167320797 hasConceptScore W2167320797C144301174 @default.

• next