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• W2167321693 abstract "Inhibition of the non-receptor tyrosine kinase ITK, a component of the T-cell receptor signalling cascade, may represent a novel treatment for allergic asthma. Here we report the structure-based optimization of a series of benzothiazole amides that demonstrate sub-nanomolar inhibitory potency against ITK with good cellular activity and kinase selectivity. We also elucidate the binding mode of these inhibitors by solving the X-ray crystal structures of several inhibitor-ITK complexes." @default.
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• W2167321693 date "2013-12-01" @default.
• W2167321693 modified "2023-10-17" @default.
• W2167321693 title "Structure-based design and synthesis of potent benzothiazole inhibitors of interleukin-2 inducible T cell kinase (ITK)" @default.
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• W2167321693 doi "https://doi.org/10.1016/j.bmcl.2013.09.069" @default.
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