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• W2167345811 endingPage "107" @default.
• W2167345811 startingPage "95" @default.
• W2167345811 abstract "The effects of 5-hydroxytryptamine (5-HT) on the inhibitory responses evoked by gamma-aminobutyric acid (GABA) in neurons of the red nucleus (RN) were studied using a microiontophoretic technique. Extracellular unitary recordings performed in anesthetized rats demonstrated that 5-HT ejection influenced GABA-evoked inhibition in 94% of RN neurons, enhancing them in 52% and depressing them in 46% of cases. Both effects were specific and dose-dependent,although enhancements or depressions of the GABA responses were respectively inversely and directly related to the doses of 5-HT applied. The type of modulation exerted by 5-HT on the GABA responses was independent of the action of the amine on background firing. In fact, 5-HT induced an enhancement of the GABA responses in neurons mostly located in the rostral RN and a depression in those in the caudal RN. The application of 8-hydroxy-2(di-n-propylamino)tetralin, a specific 5-HT(1A) receptor agonist, enhanced GABA responses, whereas alpha-methyl-5-hydroxytryptamine, a 5-HT(2A) receptor agonist, depressed them. Both the 5-HT(2) antagonist methysergide and the 5-HT(2A) selective antagonist ketanserin were able to block partially or totally the depressive action of 5-HT on GABA responses. In contrast, the same 5-HT antagonists mimicked the enhancing action of 5-HT on the GABA responses or were ineffective. Application of bicuculline, a GABA(A) receptor antagonist, enhanced the excitatory action of 5-HT on the background firing and slightly reduced the inhibitory action. It is concluded that 5-HT is able to modulate GABA-evoked responses in RN neurons by acting on both 5-HT(1A) and 5-HT(2A) receptors. The functional significance of a serotonergic control on GABAergic inhibitory effects in RN is discussed." @default.
• W2167345811 created "2016-06-24" @default.
• W2167345811 creator A5005944530 @default.
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• W2167345811 creator A5057082448 @default.
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• W2167345811 creator A5080461996 @default.
• W2167345811 date "2001-01-01" @default.
• W2167345811 modified "2023-09-23" @default.
• W2167345811 title "Serotonin Modifies the Neuronal Inhibitory Responses to γ-Aminobutyric Acid in the Red Nucleus: A Microiontophoretic Study in the Rat" @default.
• W2167345811 cites W1658674833 @default.
• W2167345811 cites W1776600188 @default.
• W2167345811 cites W1867285585 @default.
• W2167345811 cites W1897392571 @default.
• W2167345811 cites W1919168435 @default.
• W2167345811 cites W1940309328 @default.
• W2167345811 cites W1968584604 @default.
• W2167345811 cites W1968672311 @default.
• W2167345811 cites W1968952826 @default.
• W2167345811 cites W1972844328 @default.
• W2167345811 cites W1976339637 @default.
• W2167345811 cites W1978478183 @default.
• W2167345811 cites W1979743359 @default.
• W2167345811 cites W1982206672 @default.
• W2167345811 cites W1986422894 @default.
• W2167345811 cites W1988939268 @default.
• W2167345811 cites W1992227317 @default.
• W2167345811 cites W1999508272 @default.
• W2167345811 cites W2000747124 @default.
• W2167345811 cites W2001525384 @default.
• W2167345811 cites W2002517820 @default.
• W2167345811 cites W2002613842 @default.
• W2167345811 cites W2003125564 @default.
• W2167345811 cites W2003572520 @default.
• W2167345811 cites W2006924524 @default.
• W2167345811 cites W2007126039 @default.
• W2167345811 cites W2007895617 @default.
• W2167345811 cites W2010819705 @default.
• W2167345811 cites W2012176433 @default.
• W2167345811 cites W2017138204 @default.
• W2167345811 cites W2018938858 @default.
• W2167345811 cites W2022584174 @default.
• W2167345811 cites W2023673457 @default.
• W2167345811 cites W2024178220 @default.
• W2167345811 cites W2026524292 @default.
• W2167345811 cites W2026583696 @default.
• W2167345811 cites W2026629681 @default.
• W2167345811 cites W2028860498 @default.
• W2167345811 cites W2029973719 @default.
• W2167345811 cites W2030711496 @default.
• W2167345811 cites W2031850664 @default.
• W2167345811 cites W2034961437 @default.
• W2167345811 cites W2035632600 @default.
• W2167345811 cites W2038370376 @default.
• W2167345811 cites W2039118899 @default.
• W2167345811 cites W2039994392 @default.
• W2167345811 cites W2040833383 @default.
• W2167345811 cites W2043754658 @default.
• W2167345811 cites W2045313047 @default.
• W2167345811 cites W2045960952 @default.
• W2167345811 cites W2046188669 @default.
• W2167345811 cites W2046280925 @default.
• W2167345811 cites W2051022569 @default.
• W2167345811 cites W2056984059 @default.
• W2167345811 cites W2057298285 @default.
• W2167345811 cites W2062527098 @default.
• W2167345811 cites W2066665763 @default.
• W2167345811 cites W2070529167 @default.
• W2167345811 cites W2071118483 @default.
• W2167345811 cites W2071446282 @default.
• W2167345811 cites W2076332121 @default.
• W2167345811 cites W2079112157 @default.
• W2167345811 cites W2080932795 @default.
• W2167345811 cites W2084498836 @default.
• W2167345811 cites W2088007780 @default.
• W2167345811 cites W2088079706 @default.
• W2167345811 cites W2089251912 @default.
• W2167345811 cites W2090757041 @default.
• W2167345811 cites W2090783151 @default.
• W2167345811 cites W2091933807 @default.
• W2167345811 cites W2094175418 @default.
• W2167345811 cites W2113072020 @default.
• W2167345811 cites W2127453348 @default.
• W2167345811 cites W2132155906 @default.
• W2167345811 cites W2138512124 @default.
• W2167345811 cites W2138698312 @default.
• W2167345811 cites W2160649727 @default.
• W2167345811 cites W2163815564 @default.
• W2167345811 cites W2177512547 @default.
• W2167345811 cites W2199936240 @default.
• W2167345811 cites W221359381 @default.
• W2167345811 cites W2234485775 @default.
• W2167345811 cites W2283823872 @default.
• W2167345811 cites W2402369143 @default.
• W2167345811 cites W2409059026 @default.
• W2167345811 cites W2410676668 @default.
• W2167345811 cites W2423951333 @default.

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