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• W2167360242 abstract "The discovery, synthesis and biological activity of a series of triarylethane phosphodiesterase 4 inhibitors is described. Structure-activity relationship studies are presented for CDP840 (29), a potent, chiral, selective inhibitor of PDE 4 (IC(50) 4nM). CDP840 is non-emetic in the ferret at 30mgkg(-1) (po), active in models of inflammation and reverses ozone-induced bronchial hyperreactivity in the guinea pig." @default.
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• W2167360242 date "2002-06-01" @default.
• W2167360242 modified "2023-09-27" @default.
• W2167360242 title "CDP840. A prototype of a novel class of orally active anti-Inflammatory phosphodiesterase 4 inhibitors" @default.
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• W2167360242 doi "https://doi.org/10.1016/s0960-894x(02)00202-0" @default.
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