Matches in SemOpenAlex for { <https://semopenalex.org/work/W2167388045> ?p ?o ?g. }
- W2167388045 endingPage "31" @default.
- W2167388045 startingPage "22" @default.
- W2167388045 abstract "Skeletal regeneration and bone fracture repair involves complex cellular and molecular events that result in new bone formation. Many of the critical steps during bone healing are dependent on the local mechanical environment in the healing tissue. Computational models are used together with mechano-regulation algorithms to predict the influence of mechanical stimuli on the tissue differentiation process during bone healing. This paper reviews the field of computational mechanobiology with focus on bone healing. The history of mechanoregulatory modeling is described, as well as the recent advances and current problems. Most recent advances have been focusing on integrating the mechano-regulatory algorithms with more sophisticated description of the cellular and molecular events. Achieving suitable validation for the models is the most significant challenge. Thus far, focus has been on corroborating mechanoregulatory models by comparing existing models with well characterized experimental data, identify shortcomings and further develop improved computational models of bone healing. Ultimately, these models can be used to help unraveling the basic principles of cell and tissue differentiation, optimization of implant design, and potentially to investigate treatments of non-union and other pathologies." @default.
- W2167388045 created "2016-06-24" @default.
- W2167388045 creator A5074735538 @default.
- W2167388045 date "2012-06-01" @default.
- W2167388045 modified "2023-10-16" @default.
- W2167388045 title "Recent advances in mechanobiological modeling of bone regeneration" @default.
- W2167388045 cites W1901519292 @default.
- W2167388045 cites W1916156238 @default.
- W2167388045 cites W1964733232 @default.
- W2167388045 cites W1966260373 @default.
- W2167388045 cites W1970232464 @default.
- W2167388045 cites W1970237590 @default.
- W2167388045 cites W1976279664 @default.
- W2167388045 cites W1976496131 @default.
- W2167388045 cites W1979137563 @default.
- W2167388045 cites W1984307368 @default.
- W2167388045 cites W1987504060 @default.
- W2167388045 cites W1988189846 @default.
- W2167388045 cites W1992397894 @default.
- W2167388045 cites W1996862381 @default.
- W2167388045 cites W1997794453 @default.
- W2167388045 cites W2010323666 @default.
- W2167388045 cites W2010751506 @default.
- W2167388045 cites W2011039689 @default.
- W2167388045 cites W2015707570 @default.
- W2167388045 cites W2018990561 @default.
- W2167388045 cites W2020192461 @default.
- W2167388045 cites W2030474254 @default.
- W2167388045 cites W2031948569 @default.
- W2167388045 cites W2033801063 @default.
- W2167388045 cites W2036169965 @default.
- W2167388045 cites W2041911911 @default.
- W2167388045 cites W2049072682 @default.
- W2167388045 cites W2057871541 @default.
- W2167388045 cites W2058116670 @default.
- W2167388045 cites W2059107467 @default.
- W2167388045 cites W2059430791 @default.
- W2167388045 cites W2065005994 @default.
- W2167388045 cites W2065390386 @default.
- W2167388045 cites W2078932318 @default.
- W2167388045 cites W2081106783 @default.
- W2167388045 cites W2090936021 @default.
- W2167388045 cites W2094654701 @default.
- W2167388045 cites W2096965528 @default.
- W2167388045 cites W2100392764 @default.
- W2167388045 cites W2105470564 @default.
- W2167388045 cites W2109293470 @default.
- W2167388045 cites W2111312751 @default.
- W2167388045 cites W2120761640 @default.
- W2167388045 cites W2121681341 @default.
- W2167388045 cites W2125828283 @default.
- W2167388045 cites W2126754939 @default.
- W2167388045 cites W2126870355 @default.
- W2167388045 cites W2128574197 @default.
- W2167388045 cites W2130867526 @default.
- W2167388045 cites W2132905373 @default.
- W2167388045 cites W2134086845 @default.
- W2167388045 cites W2138305712 @default.
- W2167388045 cites W2140430839 @default.
- W2167388045 cites W2141841781 @default.
- W2167388045 cites W2142299558 @default.
- W2167388045 cites W2143243317 @default.
- W2167388045 cites W2147144859 @default.
- W2167388045 cites W2153427256 @default.
- W2167388045 cites W2156370249 @default.
- W2167388045 cites W2162281037 @default.
- W2167388045 cites W2169884717 @default.
- W2167388045 cites W2182108454 @default.
- W2167388045 cites W2272870230 @default.
- W2167388045 cites W2403621207 @default.
- W2167388045 cites W2988868023 @default.
- W2167388045 doi "https://doi.org/10.1016/j.mechrescom.2011.11.006" @default.
- W2167388045 hasPublicationYear "2012" @default.
- W2167388045 type Work @default.
- W2167388045 sameAs 2167388045 @default.
- W2167388045 citedByCount "66" @default.
- W2167388045 countsByYear W21673880452012 @default.
- W2167388045 countsByYear W21673880452013 @default.
- W2167388045 countsByYear W21673880452014 @default.
- W2167388045 countsByYear W21673880452015 @default.
- W2167388045 countsByYear W21673880452016 @default.
- W2167388045 countsByYear W21673880452017 @default.
- W2167388045 countsByYear W21673880452018 @default.
- W2167388045 countsByYear W21673880452019 @default.
- W2167388045 countsByYear W21673880452020 @default.
- W2167388045 countsByYear W21673880452021 @default.
- W2167388045 countsByYear W21673880452022 @default.
- W2167388045 countsByYear W21673880452023 @default.
- W2167388045 crossrefType "journal-article" @default.
- W2167388045 hasAuthorship W2167388045A5074735538 @default.
- W2167388045 hasConcept C105702510 @default.
- W2167388045 hasConcept C111919701 @default.
- W2167388045 hasConcept C120665830 @default.
- W2167388045 hasConcept C121332964 @default.
- W2167388045 hasConcept C127413603 @default.
- W2167388045 hasConcept C171056886 @default.
- W2167388045 hasConcept C183696295 @default.
- W2167388045 hasConcept C192209626 @default.