FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2167399678> ?p ?o ?g. }

• W2167399678 endingPage "1065" @default.
• W2167399678 startingPage "1060" @default.
• W2167399678 abstract "Δ-6 Desaturase, one of the rate-limiting enzymes, catalyzes the conversion of linoleic acid (C18:2 ω6) into γ-linolenic acid (C18:3 ω6), arachidonic acid (C20:4 ω6), and further metabolites. Recently, it has been shown that human Δ-6 desaturase is expressed not only in liver but in a variety of human tissues, including muscle. Skeletal muscle is a major site of insulin action, and insulin sensitivity may be related to the fatty acid composition of muscle lipids. We examined the effects of troglitazone on the regulation of Δ-6 desaturase gene expression in human muscle cell cultures obtained from muscle biopsies (n = 15). Δ-6 Desaturase mRNA and peroxisome proliferator–activated receptor γ2 (PPARγ2) mRNA were quantified by two-step RT-PCR, and the activity of the Δ-6 desaturase enzyme was estimated by gas chromatographic analysis of the ω 6-C18:3/C18:2 fatty acids ratio. In cells treated with 11.5 μmol troglitazone for 4 days, PPARγ2 mRNA levels were significantly increased (301.0 ± 51.5%, P &lt; 0.05) and Δ-6 desaturase mRNA levels were significantly decreased (41.7 ± 5.9%, P &lt; 0.0005) compared with the untreated controls. In accordance with the decrease of Δ-6 desaturase mRNA, there was a significant decrease in the ω6-C18:3/C18:2 ratio down to 47.4 ± 7.5% in cholesterol esters, 54.2 ± 7.4% in phospholipids, 56.7 ± 6.5% in nonesterified fatty acids, and 67.7 ± 5.9% in triglycerides. The troglitazone-induced decrease in Δ-6 desaturase mRNA is associated with a change in the unsaturated fatty acid composition of the muscle cells. These results add new aspects to the known thiazolidinedione effects on lipid metabolism." @default.
• W2167399678 created "2016-06-24" @default.
• W2167399678 creator A5001104617 @default.
• W2167399678 creator A5001646814 @default.
• W2167399678 creator A5034237720 @default.
• W2167399678 creator A5053898553 @default.
• W2167399678 creator A5062734974 @default.
• W2167399678 creator A5084404405 @default.
• W2167399678 date "2002-04-01" @default.
• W2167399678 modified "2023-10-14" @default.
• W2167399678 title "Troglitazone Downregulates Δ-6 Desaturase Gene Expression in Human Skeletal Muscle Cell Cultures" @default.
• W2167399678 cites W14370783 @default.
• W2167399678 cites W1569947224 @default.
• W2167399678 cites W1933801203 @default.
• W2167399678 cites W1966842587 @default.
• W2167399678 cites W1966991669 @default.
• W2167399678 cites W1994212260 @default.
• W2167399678 cites W1994468097 @default.
• W2167399678 cites W1996256476 @default.
• W2167399678 cites W2020734638 @default.
• W2167399678 cites W2022615670 @default.
• W2167399678 cites W2031965740 @default.
• W2167399678 cites W2042618169 @default.
• W2167399678 cites W2047587295 @default.
• W2167399678 cites W2047591801 @default.
• W2167399678 cites W2048925239 @default.
• W2167399678 cites W2064715676 @default.
• W2167399678 cites W2073781331 @default.
• W2167399678 cites W2089235913 @default.
• W2167399678 cites W2105912552 @default.
• W2167399678 cites W2137325725 @default.
• W2167399678 cites W2139002144 @default.
• W2167399678 cites W2169224393 @default.
• W2167399678 cites W2169951471 @default.
• W2167399678 cites W2211467290 @default.
• W2167399678 cites W2315929780 @default.
• W2167399678 cites W2335922553 @default.
• W2167399678 cites W2485778398 @default.
• W2167399678 cites W3189054443 @default.
• W2167399678 cites W4233211083 @default.
• W2167399678 cites W4234925062 @default.
• W2167399678 cites W4235000133 @default.
• W2167399678 cites W4246115764 @default.
• W2167399678 cites W4249886102 @default.
• W2167399678 cites W4252723415 @default.
• W2167399678 cites W4254533614 @default.
• W2167399678 cites W4301911629 @default.
• W2167399678 doi "https://doi.org/10.2337/diabetes.51.4.1060" @default.
• W2167399678 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11916926" @default.
• W2167399678 hasPublicationYear "2002" @default.
• W2167399678 type Work @default.
• W2167399678 sameAs 2167399678 @default.
• W2167399678 citedByCount "24" @default.
• W2167399678 countsByYear W21673996782013 @default.
• W2167399678 countsByYear W21673996782015 @default.
• W2167399678 countsByYear W21673996782018 @default.
• W2167399678 countsByYear W21673996782021 @default.
• W2167399678 crossrefType "journal-article" @default.
• W2167399678 hasAuthorship W2167399678A5001104617 @default.
• W2167399678 hasAuthorship W2167399678A5001646814 @default.
• W2167399678 hasAuthorship W2167399678A5034237720 @default.
• W2167399678 hasAuthorship W2167399678A5053898553 @default.
• W2167399678 hasAuthorship W2167399678A5062734974 @default.
• W2167399678 hasAuthorship W2167399678A5084404405 @default.
• W2167399678 hasBestOaLocation W21673996781 @default.
• W2167399678 hasConcept C104317684 @default.
• W2167399678 hasConcept C105580179 @default.
• W2167399678 hasConcept C126322002 @default.
• W2167399678 hasConcept C134018914 @default.
• W2167399678 hasConcept C150194340 @default.
• W2167399678 hasConcept C170493617 @default.
• W2167399678 hasConcept C181199279 @default.
• W2167399678 hasConcept C187345961 @default.
• W2167399678 hasConcept C2778078955 @default.
• W2167399678 hasConcept C2778150266 @default.
• W2167399678 hasConcept C2779959927 @default.
• W2167399678 hasConcept C2780809830 @default.
• W2167399678 hasConcept C2908932551 @default.
• W2167399678 hasConcept C543025807 @default.
• W2167399678 hasConcept C55493867 @default.
• W2167399678 hasConcept C71924100 @default.
• W2167399678 hasConcept C86803240 @default.
• W2167399678 hasConceptScore W2167399678C104317684 @default.
• W2167399678 hasConceptScore W2167399678C105580179 @default.
• W2167399678 hasConceptScore W2167399678C126322002 @default.
• W2167399678 hasConceptScore W2167399678C134018914 @default.
• W2167399678 hasConceptScore W2167399678C150194340 @default.
• W2167399678 hasConceptScore W2167399678C170493617 @default.
• W2167399678 hasConceptScore W2167399678C181199279 @default.
• W2167399678 hasConceptScore W2167399678C187345961 @default.
• W2167399678 hasConceptScore W2167399678C2778078955 @default.
• W2167399678 hasConceptScore W2167399678C2778150266 @default.
• W2167399678 hasConceptScore W2167399678C2779959927 @default.
• W2167399678 hasConceptScore W2167399678C2780809830 @default.
• W2167399678 hasConceptScore W2167399678C2908932551 @default.
• W2167399678 hasConceptScore W2167399678C543025807 @default.
• W2167399678 hasConceptScore W2167399678C55493867 @default.
• W2167399678 hasConceptScore W2167399678C71924100 @default.

• next