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• W2167400574 abstract "Sedentary behavior is associated with an attenuated thermogenic response to β-adrenergic receptor (β-AR) stimulation, an important regulator of energy expenditure (EE) in humans. Chronic stimulation of β-ARs, via heightened activity of the sympathoadrenal system, leads to diminished β-AR function. We have investigated the hypothesis that the thermogenic response of sedentary adults to β-AR stimulation will be increased during short-term sympathoadrenal inhibition. Using a randomly ordered, repeated measures study design, resting EE (REE; indirect calorimetry, ventilated hood technique) and the % increase in EE above REE (%ΔEE) during acute i.v. isoproterenol administration (nonselective β-AR agonist; 6, 12, and 24 ng/kg fat-free mass per min) were determined in 16 sedentary adults (nine females and seven males, 25±1 years, body mass index: 26.1±0.9 kg/m 2 , maximal oxygen uptake: 40±2 ml/kg per min (mean± s.e.m. )) in the basal state and on the 6th day of transdermal clonidine administration (centrally acting α2-AR agonist; 0.2 mg/day). Relative to baseline, clonidine inhibited sympathoadrenal activity, as evidenced by decreased plasma norepinephrine concentration (1.04±0.13 vs 0.34±0.03 nmol/l; P <0.001), skeletal muscle sympathetic nerve activity (22.5±3.8 vs 8.5±1.9 bursts/min; P =0.003), and resting heart rate (63±2 vs 49±1 beats/min; P <0.001). Sympathoadrenal inhibition decreased REE (6510±243 vs 5857±218 kJ/day; P <0.001), increased respiratory exchange ratio (0.84±0.01 vs 0.86±0.01; P =0.03), and augmented the thermogenic response to β-AR stimulation (%ΔEE: 11±2, 16±2, and 24±2 vs 14±1, 20±2, and 31±2; P =0.04). These data demonstrate that in sedentary humans, short-term inhibition of sympathoadrenal activity increases the thermogenic response to β-AR stimulation, an important determinant of EE and hence energy balance." @default.
• W2167400574 created "2016-06-24" @default.
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• W2167400574 date "2010-07-01" @default.
• W2167400574 modified "2023-09-25" @default.
• W2167400574 title "Short-term sympathoadrenal inhibition augments the thermogenic response to β-adrenergic receptor stimulation" @default.
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• W2167400574 cites W1481692664 @default.
• W2167400574 cites W1587875569 @default.
• W2167400574 cites W1597933301 @default.
• W2167400574 cites W161838358 @default.
• W2167400574 cites W195820962 @default.
• W2167400574 cites W1963739832 @default.
• W2167400574 cites W1963802628 @default.
• W2167400574 cites W1963869645 @default.
• W2167400574 cites W1966651130 @default.
• W2167400574 cites W1969606555 @default.
• W2167400574 cites W1974781285 @default.
• W2167400574 cites W1975060429 @default.
• W2167400574 cites W1976555898 @default.
• W2167400574 cites W1979038001 @default.
• W2167400574 cites W1981704156 @default.
• W2167400574 cites W1984488897 @default.
• W2167400574 cites W1986098635 @default.
• W2167400574 cites W1986710706 @default.
• W2167400574 cites W1986885124 @default.
• W2167400574 cites W1987784075 @default.
• W2167400574 cites W1993857394 @default.
• W2167400574 cites W1998111567 @default.
• W2167400574 cites W1999662289 @default.
• W2167400574 cites W2004008756 @default.
• W2167400574 cites W2009446848 @default.
• W2167400574 cites W2014965683 @default.
• W2167400574 cites W2015327820 @default.
• W2167400574 cites W2018165064 @default.
• W2167400574 cites W2023071459 @default.
• W2167400574 cites W2024870060 @default.
• W2167400574 cites W2031410052 @default.
• W2167400574 cites W2032327738 @default.
• W2167400574 cites W2035379108 @default.
• W2167400574 cites W2035758977 @default.
• W2167400574 cites W2037507482 @default.
• W2167400574 cites W2038927385 @default.
• W2167400574 cites W2041811148 @default.
• W2167400574 cites W2042116257 @default.
• W2167400574 cites W2053987168 @default.
• W2167400574 cites W2056016295 @default.
• W2167400574 cites W2057149840 @default.
• W2167400574 cites W2062573090 @default.
• W2167400574 cites W2069430994 @default.
• W2167400574 cites W2072053298 @default.
• W2167400574 cites W2073045927 @default.
• W2167400574 cites W2077662845 @default.
• W2167400574 cites W2080713593 @default.
• W2167400574 cites W2081136491 @default.
• W2167400574 cites W2085058131 @default.
• W2167400574 cites W2088580639 @default.
• W2167400574 cites W2090296913 @default.
• W2167400574 cites W2103256591 @default.
• W2167400574 cites W2108379938 @default.
• W2167400574 cites W2113579149 @default.
• W2167400574 cites W2114519559 @default.
• W2167400574 cites W2115175546 @default.
• W2167400574 cites W2115408354 @default.
• W2167400574 cites W2119173161 @default.
• W2167400574 cites W2131716859 @default.
• W2167400574 cites W2138191190 @default.
• W2167400574 cites W2138900790 @default.
• W2167400574 cites W2143893727 @default.
• W2167400574 cites W2151488417 @default.
• W2167400574 cites W2152749791 @default.
• W2167400574 cites W2153005911 @default.
• W2167400574 cites W2154353041 @default.
• W2167400574 cites W2157479235 @default.
• W2167400574 cites W2161483078 @default.
• W2167400574 cites W2165822611 @default.
• W2167400574 cites W2168078397 @default.
• W2167400574 cites W2176011184 @default.
• W2167400574 cites W2339871793 @default.
• W2167400574 cites W2341449663 @default.
• W2167400574 cites W2414033814 @default.
• W2167400574 cites W2463215628 @default.
• W2167400574 cites W2758309827 @default.
• W2167400574 cites W94138424 @default.
• W2167400574 cites W1988154967 @default.
• W2167400574 cites W2125346867 @default.
• W2167400574 doi "https://doi.org/10.1677/joe-10-0152" @default.
• W2167400574 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20603265" @default.
• W2167400574 hasPublicationYear "2010" @default.
• W2167400574 type Work @default.

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