Matches in SemOpenAlex for { <https://semopenalex.org/work/W2167432016> ?p ?o ?g. }
- W2167432016 endingPage "2278" @default.
- W2167432016 startingPage "2269" @default.
- W2167432016 abstract "Abstract Myocardin (MYOCD), a serum response factor (SRF) transcriptional cofactor, is essential for cardiac and smooth muscle development and differentiation. We show here by array-based comparative genomic hybridization, fluorescence in situ hybridization, and expression analysis approaches that MYOCD gene is highly amplified and overexpressed in human retroperitoneal leiomyosarcomas (LMS), a very aggressive well-differentiated tumor. MYOCD inactivation by shRNA in a human LMS cell line with MYOCD locus amplification leads to a dramatic decrease of smooth muscle differentiation and strongly reduces cell migration. Moreover, forced MYOCD expression in three undifferentiated sarcoma cell lines and in one liposarcoma cell line confers a strong smooth muscle differentiation phenotype and increased migration abilities. Collectively, these results show that human retroperitoneal LMS differentiation is dependent on MYOCD amplification/overexpression, suggesting that in these well-differentiated LMS, differentiation could be a consequence of an acquired genomic alteration. In this hypothesis, these tumors would not necessarily derive from cells initially committed to smooth muscle differentiation. These data also provide new insights on the cellular origin of these sarcomas and on the complex connections between oncogenesis and differentiation in mesenchymal tumors. [Cancer Res 2009;69(6):2269–78]" @default.
- W2167432016 created "2016-06-24" @default.
- W2167432016 creator A5037236636 @default.
- W2167432016 creator A5044896809 @default.
- W2167432016 creator A5047203920 @default.
- W2167432016 creator A5053604746 @default.
- W2167432016 creator A5061469135 @default.
- W2167432016 creator A5062271071 @default.
- W2167432016 creator A5062656683 @default.
- W2167432016 creator A5063675122 @default.
- W2167432016 creator A5069777709 @default.
- W2167432016 creator A5070464592 @default.
- W2167432016 date "2009-03-15" @default.
- W2167432016 modified "2023-10-16" @default.
- W2167432016 title "Strong Smooth Muscle Differentiation Is Dependent on Myocardin Gene Amplification in Most Human Retroperitoneal Leiomyosarcomas" @default.
- W2167432016 cites W1514203964 @default.
- W2167432016 cites W1912592877 @default.
- W2167432016 cites W1964820861 @default.
- W2167432016 cites W1965054867 @default.
- W2167432016 cites W1973614663 @default.
- W2167432016 cites W1995002689 @default.
- W2167432016 cites W2019222060 @default.
- W2167432016 cites W2020345226 @default.
- W2167432016 cites W2027739413 @default.
- W2167432016 cites W2028109787 @default.
- W2167432016 cites W2038491907 @default.
- W2167432016 cites W2059589829 @default.
- W2167432016 cites W2064323791 @default.
- W2167432016 cites W2066875325 @default.
- W2167432016 cites W2067561562 @default.
- W2167432016 cites W2083735736 @default.
- W2167432016 cites W2086429889 @default.
- W2167432016 cites W2089556772 @default.
- W2167432016 cites W2099348538 @default.
- W2167432016 cites W2099685153 @default.
- W2167432016 cites W2101557953 @default.
- W2167432016 cites W2101888212 @default.
- W2167432016 cites W2103571619 @default.
- W2167432016 cites W2103680698 @default.
- W2167432016 cites W2106369700 @default.
- W2167432016 cites W2110743056 @default.
- W2167432016 cites W2119644508 @default.
- W2167432016 cites W2121822802 @default.
- W2167432016 cites W2125566310 @default.
- W2167432016 cites W2128466236 @default.
- W2167432016 cites W2131666115 @default.
- W2167432016 cites W2136419196 @default.
- W2167432016 cites W2140795153 @default.
- W2167432016 cites W2143850042 @default.
- W2167432016 cites W2143879406 @default.
- W2167432016 cites W2145871238 @default.
- W2167432016 cites W2150581509 @default.
- W2167432016 cites W2152376785 @default.
- W2167432016 cites W2152979090 @default.
- W2167432016 cites W2163909549 @default.
- W2167432016 cites W2167080445 @default.
- W2167432016 cites W2167746653 @default.
- W2167432016 doi "https://doi.org/10.1158/0008-5472.can-08-1443" @default.
- W2167432016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19276386" @default.
- W2167432016 hasPublicationYear "2009" @default.
- W2167432016 type Work @default.
- W2167432016 sameAs 2167432016 @default.
- W2167432016 citedByCount "62" @default.
- W2167432016 countsByYear W21674320162012 @default.
- W2167432016 countsByYear W21674320162013 @default.
- W2167432016 countsByYear W21674320162014 @default.
- W2167432016 countsByYear W21674320162015 @default.
- W2167432016 countsByYear W21674320162016 @default.
- W2167432016 countsByYear W21674320162017 @default.
- W2167432016 countsByYear W21674320162018 @default.
- W2167432016 countsByYear W21674320162019 @default.
- W2167432016 countsByYear W21674320162020 @default.
- W2167432016 countsByYear W21674320162021 @default.
- W2167432016 countsByYear W21674320162022 @default.
- W2167432016 countsByYear W21674320162023 @default.
- W2167432016 crossrefType "journal-article" @default.
- W2167432016 hasAuthorship W2167432016A5037236636 @default.
- W2167432016 hasAuthorship W2167432016A5044896809 @default.
- W2167432016 hasAuthorship W2167432016A5047203920 @default.
- W2167432016 hasAuthorship W2167432016A5053604746 @default.
- W2167432016 hasAuthorship W2167432016A5061469135 @default.
- W2167432016 hasAuthorship W2167432016A5062271071 @default.
- W2167432016 hasAuthorship W2167432016A5062656683 @default.
- W2167432016 hasAuthorship W2167432016A5063675122 @default.
- W2167432016 hasAuthorship W2167432016A5069777709 @default.
- W2167432016 hasAuthorship W2167432016A5070464592 @default.
- W2167432016 hasBestOaLocation W21674320162 @default.
- W2167432016 hasConcept C104317684 @default.
- W2167432016 hasConcept C124942203 @default.
- W2167432016 hasConcept C142724271 @default.
- W2167432016 hasConcept C148738053 @default.
- W2167432016 hasConcept C150194340 @default.
- W2167432016 hasConcept C2777532014 @default.
- W2167432016 hasConcept C2780286377 @default.
- W2167432016 hasConcept C30481170 @default.
- W2167432016 hasConcept C502942594 @default.
- W2167432016 hasConcept C54355233 @default.
- W2167432016 hasConcept C555283112 @default.