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- W2167448082 abstract "Chloride secretion (Isc) by the opercular epithelium of the teleost, Fundulus heteroclitus, is stimulated by elevations in intracellular cyclic AMP (cAMP) elicited by β-adrenergic agonists, such as isoproterenol, and is accompanied by a small but significant increase in the transepithelial conductance (Gt). Cupric ions (Cu2+) have been shown to block the apical membrane CI− channels in this epithelium, leading to a reduction in both the Isc and Gt (Degnan, '85). In the present studies, the effects of Cu2+ on cAMP-elevated and cAMP-depleted epithelia were observed to define the actions of cAMP in this stimulatory process. At a concentration of 5 × 10−4 M in the mucosal solution, Cu2+ inhibited the Isc 79.8% and reduced the Gt 39.2%. Isoproterenol produced an attenuated stimulation of the Isc in these tissues compared to untreated controls, but had no effect on the Gt. In tissues bathed bilaterally with Cl− -free Ringer, the Isc was virtually abolished and the Gt was reduced 37.0%; neither Cu2+ nor isoproterenol had any effects on the Isc or Gt under this condition. Simultaneous 22Na and 36 Cl unidirectional flux determinations indicated that the only effects of both isoproterenol and Cu2+ were on the active Cl- secretory flux. An inhibitor of adenylate cyclase, 2′,5′ dideoxyadenosine (DDA), reduced the Isc and Gt 39.8% and 20.8% respectively. This inhibitor had no additional effects in Cu2+ -treated tissues and the action of Cu2+ on the Gt was reduced in DDA-treated tissues. The results indicate that cAMP stimulation of Cl− secretion involves only the active transcellular Cl− pathway and is accomplished in part by an increase in a Cl− -dependent, mucosal Cu2+ -inhibitable increase in the Gt, which is most likely localized to the apical membrane of the chloride cell." @default.
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- W2167448082 date "1986-05-01" @default.
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- W2167448082 title "Cyclic AMP stimulation of Cl− secretion by the opercular epithelium: The apical membrane chloride conductance" @default.
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- W2167448082 doi "https://doi.org/10.1002/jez.1402380203" @default.
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