FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2167496970> ?p ?o ?g. }

• W2167496970 endingPage "16" @default.
• W2167496970 startingPage "1" @default.
• W2167496970 abstract "Experimental sepsis in rodents occurring after cecal ligation/puncture (CLP) is associated with excessive complement activation and a systemic inflammatory response. The proinflammatory mediator IL-6 has recently been shown to be an important inducer of the C5a receptor (C5aR) during sepsis. We now provide evidence that serum IL-6 production during sepsis in rats was reduced in neutrophil-depleted animals and that absence of C5aR in mice as well as antibody-blockade of C5a in rats significantly reduced serum levels of IL-6 during sepsis. Lipopolysaccharide (LPS)-induced production in vitro of IL-6 by neutrophils was significantly enhanced in the co-presence of C5a, likely due to transcriptional up-regulation of IL-6. Production of IL-6 in neutrophils by LPS was NF-kappaB dependent (but not on the presence of p50) and dependent on phosphorylation of p38-mitogen activated protein kinase (MAPK) as well as p44/p42 MAPK (ERK1/2) but not on phosphorylation of c-Jun N-terminal kinases (JNK1/2). C5a stimulation of neutrophils elicited a rapid phosphorylation of ERK1/2 and p38 MAPK. Accordingly, we suggest that induction of IL-6 after CLP is neutrophil and C5a/C5aR dependent, likely due to the ability of C5a to cause activation of ERK1/2 and p38 MAPK signaling pathways." @default.
• W2167496970 created "2016-06-24" @default.
• W2167496970 creator A5033791165 @default.
• W2167496970 creator A5042966626 @default.
• W2167496970 creator A5043146312 @default.
• W2167496970 creator A5043890004 @default.
• W2167496970 creator A5050363226 @default.
• W2167496970 creator A5053945938 @default.
• W2167496970 creator A5054719216 @default.
• W2167496970 creator A5068472822 @default.
• W2167496970 creator A5070016566 @default.
• W2167496970 creator A5073571042 @default.
• W2167496970 creator A5091556449 @default.
• W2167496970 date "2003-12-19" @default.
• W2167496970 modified "2023-10-14" @default.
• W2167496970 title "Regulatory role of C5a in LPS‐induced IL‐6 production by neutrophils during sepsis" @default.
• W2167496970 cites W1569271652 @default.
• W2167496970 cites W1590582894 @default.
• W2167496970 cites W1592616574 @default.
• W2167496970 cites W1871608914 @default.
• W2167496970 cites W1890847758 @default.
• W2167496970 cites W1984312127 @default.
• W2167496970 cites W2026972996 @default.
• W2167496970 cites W2029354317 @default.
• W2167496970 cites W2034345422 @default.
• W2167496970 cites W2044537496 @default.
• W2167496970 cites W2049088012 @default.
• W2167496970 cites W2054116154 @default.
• W2167496970 cites W2059730733 @default.
• W2167496970 cites W207029473 @default.
• W2167496970 cites W2090109532 @default.
• W2167496970 cites W2110433952 @default.
• W2167496970 cites W2137216847 @default.
• W2167496970 cites W2146800979 @default.
• W2167496970 cites W2147876577 @default.
• W2167496970 cites W2155611113 @default.
• W2167496970 cites W2173549073 @default.
• W2167496970 cites W4235898601 @default.
• W2167496970 doi "https://doi.org/10.1096/fj.03-0708fje" @default.
• W2167496970 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14688199" @default.
• W2167496970 hasPublicationYear "2003" @default.
• W2167496970 type Work @default.
• W2167496970 sameAs 2167496970 @default.
• W2167496970 citedByCount "154" @default.
• W2167496970 countsByYear W21674969702012 @default.
• W2167496970 countsByYear W21674969702013 @default.
• W2167496970 countsByYear W21674969702014 @default.
• W2167496970 countsByYear W21674969702015 @default.
• W2167496970 countsByYear W21674969702016 @default.
• W2167496970 countsByYear W21674969702017 @default.
• W2167496970 countsByYear W21674969702018 @default.
• W2167496970 countsByYear W21674969702019 @default.
• W2167496970 countsByYear W21674969702020 @default.
• W2167496970 countsByYear W21674969702021 @default.
• W2167496970 countsByYear W21674969702022 @default.
• W2167496970 countsByYear W21674969702023 @default.
• W2167496970 crossrefType "journal-article" @default.
• W2167496970 hasAuthorship W2167496970A5033791165 @default.
• W2167496970 hasAuthorship W2167496970A5042966626 @default.
• W2167496970 hasAuthorship W2167496970A5043146312 @default.
• W2167496970 hasAuthorship W2167496970A5043890004 @default.
• W2167496970 hasAuthorship W2167496970A5050363226 @default.
• W2167496970 hasAuthorship W2167496970A5053945938 @default.
• W2167496970 hasAuthorship W2167496970A5054719216 @default.
• W2167496970 hasAuthorship W2167496970A5068472822 @default.
• W2167496970 hasAuthorship W2167496970A5070016566 @default.
• W2167496970 hasAuthorship W2167496970A5073571042 @default.
• W2167496970 hasAuthorship W2167496970A5091556449 @default.
• W2167496970 hasBestOaLocation W21674969702 @default.
• W2167496970 hasConcept C111684460 @default.
• W2167496970 hasConcept C11960822 @default.
• W2167496970 hasConcept C126322002 @default.
• W2167496970 hasConcept C164027704 @default.
• W2167496970 hasConcept C184235292 @default.
• W2167496970 hasConcept C185592680 @default.
• W2167496970 hasConcept C203014093 @default.
• W2167496970 hasConcept C24998067 @default.
• W2167496970 hasConcept C2776914184 @default.
• W2167496970 hasConcept C2778384902 @default.
• W2167496970 hasConcept C2778754761 @default.
• W2167496970 hasConcept C2779499704 @default.
• W2167496970 hasConcept C51551487 @default.
• W2167496970 hasConcept C57074206 @default.
• W2167496970 hasConcept C62478195 @default.
• W2167496970 hasConcept C71924100 @default.
• W2167496970 hasConcept C86803240 @default.
• W2167496970 hasConcept C8891405 @default.
• W2167496970 hasConcept C95444343 @default.
• W2167496970 hasConcept C97029542 @default.
• W2167496970 hasConceptScore W2167496970C111684460 @default.
• W2167496970 hasConceptScore W2167496970C11960822 @default.
• W2167496970 hasConceptScore W2167496970C126322002 @default.
• W2167496970 hasConceptScore W2167496970C164027704 @default.
• W2167496970 hasConceptScore W2167496970C184235292 @default.
• W2167496970 hasConceptScore W2167496970C185592680 @default.
• W2167496970 hasConceptScore W2167496970C203014093 @default.
• W2167496970 hasConceptScore W2167496970C24998067 @default.
• W2167496970 hasConceptScore W2167496970C2776914184 @default.

• next