SemOpenAlex |

SemOpenAlex

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2167503546> ?p ?o ?g. }

Showing items 1 to 100 of ±130 with 100 items per page.

W2167503546 endingPage "6" @default.
W2167503546 startingPage "1220" @default.
W2167503546 abstract "Cyclin E/cyclin-dependent kinase 2 complexes are essential during the cell cycle for entrance into S phase. Cyclin E expression starts in mid-G1, reaches a maximum at S-phase entrance, and undergoes proteolysis mediated by the ubiquitin pathway as the cell progresses through S phase. Laser scanning cytometry, a microscope-based cytofluorometer combining the advantages of both flow and image analysis, allowed the determination of subcellular localization of cyclin E, p27, and retinoblastoma protein during cell cycle progression in normal human fibroblasts and nine bladder cancer cell lines. We observed that in normal fibroblasts and most tumor cell lines, cyclin E localizes in the nucleoplasm during mid-G1, and is translocated to the nucleolus during G1-S-phase transition, and its levels are undetectable in G2-M phase. Neither levels nor subcellular localization of p27 and retinoblastoma protein was cell cycle dependent in normal or tumor cells. However, four of nine bladder cancer cell lines continued to express cyclin E in all phases of the cycle, and image analysis revealed that it was localized to nucleoli. These observations suggest that the nucleolus mediates a cyclin E shuttling between the nucleus and the cytoplasm that is probably involved in its regulation and that this mechanism could be disrupted in bladder cancer." @default.
W2167503546 created "2016-06-24" @default.
W2167503546 creator A5026768105 @default.
W2167503546 creator A5080940311 @default.
W2167503546 date "2001-02-01" @default.
W2167503546 modified "2023-10-18" @default.
W2167503546 title "Intranuclear compartmentalization of cyclin E during the cell cycle: disruption of the nucleoplasm-nucleolar shuttling of cyclin E in bladder cancer." @default.
W2167503546 cites W1518721136 @default.
W2167503546 cites W1533516721 @default.
W2167503546 cites W1537149667 @default.
W2167503546 cites W1541979189 @default.
W2167503546 cites W1569755992 @default.
W2167503546 cites W1605339326 @default.
W2167503546 cites W177595770 @default.
W2167503546 cites W1795591747 @default.
W2167503546 cites W1899599332 @default.
W2167503546 cites W1958160711 @default.
W2167503546 cites W1971254046 @default.
W2167503546 cites W1972434237 @default.
W2167503546 cites W1973052124 @default.
W2167503546 cites W1978326676 @default.
W2167503546 cites W1983751803 @default.
W2167503546 cites W1987218130 @default.
W2167503546 cites W1989589242 @default.
W2167503546 cites W1991101546 @default.
W2167503546 cites W1996834340 @default.
W2167503546 cites W1999330214 @default.
W2167503546 cites W2004008931 @default.
W2167503546 cites W2014222675 @default.
W2167503546 cites W2018138643 @default.
W2167503546 cites W2036524303 @default.
W2167503546 cites W2039262401 @default.
W2167503546 cites W2039463309 @default.
W2167503546 cites W2045589197 @default.
W2167503546 cites W2047899422 @default.
W2167503546 cites W2055099935 @default.
W2167503546 cites W2063856790 @default.
W2167503546 cites W2065252383 @default.
W2167503546 cites W2081970496 @default.
W2167503546 cites W2084147994 @default.
W2167503546 cites W2084891010 @default.
W2167503546 cites W2086082161 @default.
W2167503546 cites W2095129265 @default.
W2167503546 cites W2117795134 @default.
W2167503546 cites W2137249911 @default.
W2167503546 cites W2144381328 @default.
W2167503546 cites W2156910991 @default.
W2167503546 cites W2317786914 @default.
W2167503546 cites W2321900095 @default.
W2167503546 cites W2396119359 @default.
W2167503546 cites W2396213387 @default.
W2167503546 cites W2407368528 @default.
W2167503546 cites W635996316 @default.
W2167503546 cites W2429592862 @default.
W2167503546 cites W2978060676 @default.
W2167503546 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11221854" @default.
W2167503546 hasPublicationYear "2001" @default.
W2167503546 type Work @default.
W2167503546 sameAs 2167503546 @default.
W2167503546 citedByCount "22" @default.
W2167503546 countsByYear W21675035462013 @default.
W2167503546 countsByYear W21675035462014 @default.
W2167503546 countsByYear W21675035462015 @default.
W2167503546 countsByYear W21675035462016 @default.
W2167503546 countsByYear W21675035462017 @default.
W2167503546 countsByYear W21675035462018 @default.
W2167503546 countsByYear W21675035462019 @default.
W2167503546 countsByYear W21675035462022 @default.
W2167503546 crossrefType "journal-article" @default.
W2167503546 hasAuthorship W2167503546A5026768105 @default.
W2167503546 hasAuthorship W2167503546A5080940311 @default.
W2167503546 hasConcept C112952253 @default.
W2167503546 hasConcept C11882975 @default.
W2167503546 hasConcept C120089663 @default.
W2167503546 hasConcept C120504264 @default.
W2167503546 hasConcept C1491633281 @default.
W2167503546 hasConcept C16438837 @default.
W2167503546 hasConcept C183873130 @default.
W2167503546 hasConcept C190062978 @default.
W2167503546 hasConcept C199835354 @default.
W2167503546 hasConcept C2776062698 @default.
W2167503546 hasConcept C2776879804 @default.
W2167503546 hasConcept C2778437423 @default.
W2167503546 hasConcept C28179978 @default.
W2167503546 hasConcept C29537977 @default.
W2167503546 hasConcept C54355233 @default.
W2167503546 hasConcept C86803240 @default.
W2167503546 hasConcept C94561458 @default.
W2167503546 hasConcept C95444343 @default.
W2167503546 hasConcept C9743823 @default.
W2167503546 hasConceptScore W2167503546C112952253 @default.
W2167503546 hasConceptScore W2167503546C11882975 @default.
W2167503546 hasConceptScore W2167503546C120089663 @default.
W2167503546 hasConceptScore W2167503546C120504264 @default.
W2167503546 hasConceptScore W2167503546C1491633281 @default.
W2167503546 hasConceptScore W2167503546C16438837 @default.
W2167503546 hasConceptScore W2167503546C183873130 @default.
W2167503546 hasConceptScore W2167503546C190062978 @default.