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- W2167512113 abstract "The embryonic chick is able to regenerate the retina after it has been removed. We have previously shown that proliferating stem/progenitor cells present in the ciliary body/ciliary marginal zone (CB/CMZ) of the chick eye are responsible for regeneration, which can be induced by ectopic fibroblast growth factor-2 (FGF2) or Sonic hedgehog (Shh). Here, we reveal the mechanisms showing how FGF2 and Shh signaling are interdependent during retina regeneration. If the FGF pathway is inhibited, regeneration stimulated by Shh is inhibited. Likewise, if the Hedgehog pathway is inhibited, regeneration stimulated by FGF2 is inhibited. We examined early signaling events in the CB/CMZ and found that FGF2 or Shh induced a robust Erk phosphorylation during the early stages of retina regeneration. Shh also up-regulated the expression of several members of the FGF signaling pathway. We show that ectopic FGF2 or Shh overexpression increased the number of phosphohistone 3 (PH3)-positive cells in the CB/CMZ and inhibition of either pathway decreased the number of PH3-positive cells. Additionally, both FGF and Hh signaling are required for cell survival in the CB/CMZ, whereas Hh and not FGF signaling plays a role in maintaining the identity of the retinal progenitor population in this region. Combined, our results support a model where the FGF and Hedgehog pathways work together to stimulate retina regeneration." @default.
- W2167512113 created "2016-06-24" @default.
- W2167512113 creator A5019335002 @default.
- W2167512113 creator A5040983764 @default.
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- W2167512113 date "2007-03-26" @default.
- W2167512113 modified "2023-10-06" @default.
- W2167512113 title "Fibroblast growth factor-hedgehog interdependence during retina regeneration" @default.
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- W2167512113 doi "https://doi.org/10.1002/dvdy.21115" @default.
- W2167512113 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2587111" @default.
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- W2167512113 hasPublicationYear "2007" @default.
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