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• W2167573138 abstract "APP is a transmembrane precursor of beta-amyloid, and its mutations cause early-onset familial Alzheimer's disease. We report a toxic function of normal wild-type APP (wtAPP). Treatment of neuronal F11 cells, immortalized embryonic day 13 neurons, overexpressing wtAPP with anti-APP antibodies caused death. Death was not induced by antibody in parental F11 cells. Death by antibody occurred through cell-surface APP, not through secreted APP, in a pertussis toxin-sensitive manner and was typical apoptosis, not observed in primary astrocytes or glioma cells overexpressing wtAPP, but observed in primary cortical neurons. Cell-surface APP thus performs a toxic function as an extracellularly controllable regulator of neuronal death. This study provides a novel insight into the normal and pathological functions of cell-surface wtAPP." @default.
• W2167573138 created "2016-06-24" @default.
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• W2167573138 date "2000-12-01" @default.
• W2167573138 modified "2023-10-03" @default.
• W2167573138 title "Antibody-Regulated Neurotoxic Function of Cell-Surface β-Amyloid Precursor Protein" @default.
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• W2167573138 doi "https://doi.org/10.1006/mcne.2000.0910" @default.
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