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• W2167585655 abstract "Kappa opioid receptor (KOR) agonists are potentially valuable as therapeutics for the treatment of psychostimulant reward as they suppress dopamine signaling in reward circuitry to repress drug seeking behavior. However, KOR agonists are also associated with sedation and cognitive dysfunction. The extent to which learning and memory disruption or hypolocomotion underlie KOR agonists’ role in counteracting the rewarding effects of psychostimulants is of interest. C57BL/6J mice were pretreated with vehicle (saline, 0.9%), the KOR agonist (trans)-3,4-dichloro-N-methyl-N-[2-(1- pyrrolidinyl)-cyclohexyl] benzeneacetamide (U50,488), or the peripherally-restricted agonist D-Phe-D-Phe-D-lle-D-Arg- NH 2 (ffir-NH 2 ), through central (i.c.v.) or peripheral (i.p.) routes of administration. Locomotor activity was assessed via activity monitoring chambers and rotorod. Cognitive performance was assessed in a novel object recognition task. Prolonged hypolocomotion was observed following administration of 1.0 and 10.0, but not 0.3 mg/kg U50,488. Central, but not peripheral, administration of ffir-NH 2 (a KOR agonist that does not cross the blood-brain barrier) also reduced motor behavior. Systemic pretreatment with the low dose of U50,488 (0.3 mg/kg, i.p.) significantly impaired performance in the novel object recognition task. Likewise, ffir-NH 2 significantly reduced novel object recognition after central (i.c.v.), but not peripheral (i.p.), administration. U50,488- and ffir-NH 2 -mediated deficits in novel object recognition were prevented by pretreatment with KOR antagonists. Cocaine-induced conditioned place preference was subsequently assessed and was reduced by pretreatment with U50,488 (0.3 mg/kg, i.p.). Together, these results suggest that the activation of centrally-located kappa opioid receptors may induce cognitive and mnemonic disruption independent of hypolocomotor effects which may contribute to the KOR-mediated suppression of psychostimulant reward." @default.
• W2167585655 created "2016-06-24" @default.
• W2167585655 creator A5014443035 @default.
• W2167585655 creator A5019826093 @default.
• W2167585655 creator A5027117921 @default.
• W2167585655 date "2012-01-01" @default.
• W2167585655 modified "2023-09-27" @default.
• W2167585655 title "Kappa Opioid Receptor-Mediated Disruption of Novel Object Recognition: Relevance for Psychostimulant Treatment" @default.
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• W2167585655 doi "https://doi.org/10.4172/2155-6105.s4-007" @default.
• W2167585655 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3418884" @default.
• W2167585655 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22900234" @default.
• W2167585655 hasPublicationYear "2012" @default.
• W2167585655 type Work @default.
• W2167585655 sameAs 2167585655 @default.

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