Matches in SemOpenAlex for { <https://semopenalex.org/work/W2167597391> ?p ?o ?g. }
- W2167597391 endingPage "4232" @default.
- W2167597391 startingPage "4202" @default.
- W2167597391 abstract "Interleukin 1β (IL-1β) and tumor necrosis factor α (TNF-α) are key cytokines that drive the production of inflammatory mediators and matrix-degrading enzymes in osteoarthritis (OA). These proinflammatory cytokines bind to their respective cell surface receptors and activate inflammatory signaling pathways culminating with the activation of nuclear factor κB (NF-κB), a transcription factor that can be triggered by a host of stress-related stimuli including, excessive mechanical stress and ECM degradation products. Once activated, NF-κB regulates the expression of many cytokines, chemokines, adhesion molecules, inflammatory mediators, and several matrix-degrading enzymes. Therefore, proinflammatory cytokines, their cell surface receptors, NF-κB and downstream signaling pathways are therapeutic targets in OA. This paper critically reviews the recent literature and outlines the potential prophylactic properties of plant-derived phytochemicals such as curcumin and resveratrol for targeting NF-κB signaling and inflammation in OA to determine whether these phytochemicals can be used as functional foods." @default.
- W2167597391 created "2016-06-24" @default.
- W2167597391 creator A5012454701 @default.
- W2167597391 creator A5013076020 @default.
- W2167597391 creator A5038295064 @default.
- W2167597391 creator A5040514210 @default.
- W2167597391 date "2012-03-30" @default.
- W2167597391 modified "2023-10-18" @default.
- W2167597391 title "Scientific Evidence and Rationale for the Development of Curcumin and Resveratrol as Nutraceutricals for Joint Health" @default.
- W2167597391 cites W1497854809 @default.
- W2167597391 cites W1514533495 @default.
- W2167597391 cites W1515504649 @default.
- W2167597391 cites W152686937 @default.
- W2167597391 cites W1536009146 @default.
- W2167597391 cites W1543653831 @default.
- W2167597391 cites W1548219170 @default.
- W2167597391 cites W1550871940 @default.
- W2167597391 cites W1576189384 @default.
- W2167597391 cites W1592105850 @default.
- W2167597391 cites W1605399752 @default.
- W2167597391 cites W163712722 @default.
- W2167597391 cites W1684328282 @default.
- W2167597391 cites W179053432 @default.
- W2167597391 cites W183162841 @default.
- W2167597391 cites W186207767 @default.
- W2167597391 cites W1881147845 @default.
- W2167597391 cites W1951871380 @default.
- W2167597391 cites W1952836099 @default.
- W2167597391 cites W1957489746 @default.
- W2167597391 cites W1965307247 @default.
- W2167597391 cites W1967136516 @default.
- W2167597391 cites W1967269017 @default.
- W2167597391 cites W1968752922 @default.
- W2167597391 cites W1968937965 @default.
- W2167597391 cites W1969540068 @default.
- W2167597391 cites W1969721611 @default.
- W2167597391 cites W1973058491 @default.
- W2167597391 cites W1976194786 @default.
- W2167597391 cites W1981072821 @default.
- W2167597391 cites W1982142411 @default.
- W2167597391 cites W1983072511 @default.
- W2167597391 cites W1983294585 @default.
- W2167597391 cites W1983341626 @default.
- W2167597391 cites W1985810003 @default.
- W2167597391 cites W1988339898 @default.
- W2167597391 cites W1988924807 @default.
- W2167597391 cites W1989271162 @default.
- W2167597391 cites W1989969820 @default.
- W2167597391 cites W1990674638 @default.
- W2167597391 cites W1991758957 @default.
- W2167597391 cites W1992724479 @default.
- W2167597391 cites W1992931301 @default.
- W2167597391 cites W1995577167 @default.
- W2167597391 cites W1998161526 @default.
- W2167597391 cites W1999658463 @default.
- W2167597391 cites W2000098379 @default.
- W2167597391 cites W2002128178 @default.
- W2167597391 cites W2002884676 @default.
- W2167597391 cites W2002991417 @default.
- W2167597391 cites W2005657907 @default.
- W2167597391 cites W2010349134 @default.
- W2167597391 cites W2014136110 @default.
- W2167597391 cites W2015484191 @default.
- W2167597391 cites W2016580415 @default.
- W2167597391 cites W2016606129 @default.
- W2167597391 cites W2016652018 @default.
- W2167597391 cites W2017065497 @default.
- W2167597391 cites W2017195508 @default.
- W2167597391 cites W2017869529 @default.
- W2167597391 cites W2019147692 @default.
- W2167597391 cites W2021021216 @default.
- W2167597391 cites W2022721848 @default.
- W2167597391 cites W2024171962 @default.
- W2167597391 cites W2026033716 @default.
- W2167597391 cites W2026802983 @default.
- W2167597391 cites W2027404394 @default.
- W2167597391 cites W2028773046 @default.
- W2167597391 cites W2029020420 @default.
- W2167597391 cites W2031361940 @default.
- W2167597391 cites W2031504111 @default.
- W2167597391 cites W2033511986 @default.
- W2167597391 cites W2035727420 @default.
- W2167597391 cites W2037544224 @default.
- W2167597391 cites W2038083756 @default.
- W2167597391 cites W2039225176 @default.
- W2167597391 cites W2039354633 @default.
- W2167597391 cites W2042473209 @default.
- W2167597391 cites W2043750179 @default.
- W2167597391 cites W2044553496 @default.
- W2167597391 cites W2049140021 @default.
- W2167597391 cites W2051618060 @default.
- W2167597391 cites W2054500578 @default.
- W2167597391 cites W2055340082 @default.
- W2167597391 cites W2056669249 @default.
- W2167597391 cites W2060209614 @default.
- W2167597391 cites W2060263520 @default.
- W2167597391 cites W2060282267 @default.
- W2167597391 cites W2063195650 @default.