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- W2167607663 abstract "Luteolin and its derived glycosides such as a cynaroside, cesioside, isoorientin and stereolensin have been isolated and identified from different kinds of plant species. A 13C NMR spectroscopic analysis of stereolensin has been done for the first time. These structurally related flavonoids were examined in vitro for their abilities to inhibit enzymes for the synthesis of thromboxane B2 and leukotriene B4 as well as hydrogen peroxide scavenging activity. Luteolin exhibited a high inhibitory activity against both thromboxane and leukotriene synthesis. In particular, a remarkable inhibitory effect was observed against leukotriene enzyme activity. The glycosides, cynaroside and cesioside, possessed a moderate inhibition activity against both enzyme synthesis pathways, while isoorientin and stereolensin exhibited selectively good activity against thromboxane synthesis. All the flavonoids showed excellent scavenging activity for the hydrogen peroxide at all the concentrations tested. The results demonstrated that the reactivities of luteolin and its related glycosides against arachidonic acid synthesis and hydrogen peroxide scavenging are dependent on their molecular structures. The presence of ortho-dihydroxy groups at the B ring and OH substitution pattern at C-5 position of the A ring could sig-nificantly contribute to the antiinflammatory and antioxidant activities of flavonoids. Copyright © 2005 John Wiley & Sons, Ltd." @default.
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- W2167607663 date "2005-01-01" @default.
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- W2167607663 title "Structure-activity relationship for antiinflammatory effect of luteolin and its derived glycosides" @default.
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- W2167607663 doi "https://doi.org/10.1002/ptr.1723" @default.
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