Matches in SemOpenAlex for { <https://semopenalex.org/work/W2167609175> ?p ?o ?g. }
- W2167609175 endingPage "2907" @default.
- W2167609175 startingPage "2899" @default.
- W2167609175 abstract "ABSTRACT Lawsonia intracellularis has been identified recently as the etiological agent of proliferative enteropathies, which are characterized by intestinal epithelial hyperplasia and associated moderate immune responses. This disease complex has been reported in a broad range of animals, prevalently in pigs, and L. intracellularis has been linked with ulcerative colitis in humans. L. intracellularis is an obligate intracellular bacterium, and the pathogenic mechanisms used to cause disease are unknown. Using in vitro-grown organisms as a source of genomic DNA, we identified a Lawsonia gene which encodes a surface antigen, LsaA (for Lawsonia surface antigen), associated with attachment to and entry into cells. The deduced amino acid sequence of this protein showed some similarity to members of a novel protein family identified in a number of other bacterial pathogens but for which roles are not fully defined. Transcription of this gene was detected by reverse transcription-PCR in L. intracellularis grown in vitro in IEC18 cells and in bacteria present in ileal tissue from infected animals. Immunohistochemistry with specific monoclonal antibody and immunoblotting with sera from infected animals demonstrated that LsaA protein is synthesized by L. intracellularis during infection. Expression of this gene during infection in vitro and in vivo suggests that this surface antigen is involved during infection, and phenotypic analysis indicated a role during L. intracellularis attachment to and entry into intestinal epithelial cells" @default.
- W2167609175 created "2016-06-24" @default.
- W2167609175 creator A5017182991 @default.
- W2167609175 creator A5023116254 @default.
- W2167609175 creator A5025684744 @default.
- W2167609175 creator A5040797225 @default.
- W2167609175 creator A5062067494 @default.
- W2167609175 date "2002-06-01" @default.
- W2167609175 modified "2023-09-23" @default.
- W2167609175 title "LsaA, an Antigen Involved in Cell Attachment and Invasion, Is Expressed by <i>Lawsonia intracellularis</i> during Infection In Vitro and In Vivo" @default.
- W2167609175 cites W1481067466 @default.
- W2167609175 cites W1569904835 @default.
- W2167609175 cites W1627863859 @default.
- W2167609175 cites W1914443967 @default.
- W2167609175 cites W1926303070 @default.
- W2167609175 cites W1955452968 @default.
- W2167609175 cites W1957354265 @default.
- W2167609175 cites W1966856549 @default.
- W2167609175 cites W1967311291 @default.
- W2167609175 cites W1975922539 @default.
- W2167609175 cites W1987985249 @default.
- W2167609175 cites W1990318795 @default.
- W2167609175 cites W1997818957 @default.
- W2167609175 cites W2000160850 @default.
- W2167609175 cites W2005848280 @default.
- W2167609175 cites W2015708879 @default.
- W2167609175 cites W2016299826 @default.
- W2167609175 cites W2031155636 @default.
- W2167609175 cites W2037830428 @default.
- W2167609175 cites W2044934550 @default.
- W2167609175 cites W2065412253 @default.
- W2167609175 cites W2066152299 @default.
- W2167609175 cites W2073759966 @default.
- W2167609175 cites W2080557310 @default.
- W2167609175 cites W2086208676 @default.
- W2167609175 cites W2097224901 @default.
- W2167609175 cites W2097818551 @default.
- W2167609175 cites W2098056104 @default.
- W2167609175 cites W2104714420 @default.
- W2167609175 cites W2110132014 @default.
- W2167609175 cites W2111527827 @default.
- W2167609175 cites W2113111972 @default.
- W2167609175 cites W2118004780 @default.
- W2167609175 cites W2120904752 @default.
- W2167609175 cites W2129469077 @default.
- W2167609175 cites W2131224578 @default.
- W2167609175 cites W2136737291 @default.
- W2167609175 cites W2142452543 @default.
- W2167609175 cites W2155870890 @default.
- W2167609175 cites W2164485104 @default.
- W2167609175 cites W2168669146 @default.
- W2167609175 cites W246895967 @default.
- W2167609175 cites W4211020972 @default.
- W2167609175 doi "https://doi.org/10.1128/iai.70.6.2899-2907.2002" @default.
- W2167609175 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/128020" @default.
- W2167609175 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12010978" @default.
- W2167609175 hasPublicationYear "2002" @default.
- W2167609175 type Work @default.
- W2167609175 sameAs 2167609175 @default.
- W2167609175 citedByCount "29" @default.
- W2167609175 countsByYear W21676091752014 @default.
- W2167609175 countsByYear W21676091752015 @default.
- W2167609175 countsByYear W21676091752017 @default.
- W2167609175 countsByYear W21676091752018 @default.
- W2167609175 countsByYear W21676091752019 @default.
- W2167609175 countsByYear W21676091752021 @default.
- W2167609175 countsByYear W21676091752022 @default.
- W2167609175 crossrefType "journal-article" @default.
- W2167609175 hasAuthorship W2167609175A5017182991 @default.
- W2167609175 hasAuthorship W2167609175A5023116254 @default.
- W2167609175 hasAuthorship W2167609175A5025684744 @default.
- W2167609175 hasAuthorship W2167609175A5040797225 @default.
- W2167609175 hasAuthorship W2167609175A5062067494 @default.
- W2167609175 hasBestOaLocation W21676091752 @default.
- W2167609175 hasConcept C147483822 @default.
- W2167609175 hasConcept C159047783 @default.
- W2167609175 hasConcept C159654299 @default.
- W2167609175 hasConcept C203014093 @default.
- W2167609175 hasConcept C2908609012 @default.
- W2167609175 hasConcept C86803240 @default.
- W2167609175 hasConcept C8891405 @default.
- W2167609175 hasConcept C89423630 @default.
- W2167609175 hasConceptScore W2167609175C147483822 @default.
- W2167609175 hasConceptScore W2167609175C159047783 @default.
- W2167609175 hasConceptScore W2167609175C159654299 @default.
- W2167609175 hasConceptScore W2167609175C203014093 @default.
- W2167609175 hasConceptScore W2167609175C2908609012 @default.
- W2167609175 hasConceptScore W2167609175C86803240 @default.
- W2167609175 hasConceptScore W2167609175C8891405 @default.
- W2167609175 hasConceptScore W2167609175C89423630 @default.
- W2167609175 hasIssue "6" @default.
- W2167609175 hasLocation W21676091751 @default.
- W2167609175 hasLocation W21676091752 @default.
- W2167609175 hasLocation W21676091753 @default.
- W2167609175 hasOpenAccess W2167609175 @default.
- W2167609175 hasPrimaryLocation W21676091751 @default.
- W2167609175 hasRelatedWork W1484759019 @default.
- W2167609175 hasRelatedWork W2054816609 @default.