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- W2167620912 abstract "Abstract. Platelet thromboxane B2 production was studied in forty-seven non-insulin-dependent diabetics by incubating platelets with increasing concentrations of arachidonic acid. In comparison with thirty-two healthy subjects, diabetics showed increased thromboxane B2 production at 0·7 mmol/l (mean: 236 pmol/108 platelets, SEM 201–277; v. 135, 105–174; P < 0·05) and at 1·0 mmol/l (673, 613–739; v. 405, 377–486, P < 0·01) but not at 0·5 mmol/l. Patients were subdivided according to the presence or absence of vascular complications. Patients without microangiopathy showed significantly greater thromboxane B2 production than healthy subjects at all the arachidonic-acid concentrations (P < 0·02 or less). Patients with microangiopathy had platelet thromboxane production similar to that observed in healthy subjects at all the arachidonic-acid concentrations (P > 0·30) but significantly lower than that of non-microangiopathic patients at 0·5 (P < 0·01) and at 0·7 mmol/l arachidonic acid (P < 0·05). These results indicate that non-insulin-dependent diabetics have increased production of platelet thromboxane B2 only when they do not have microvascular complications." @default.
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- W2167620912 date "1984-04-01" @default.
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- W2167620912 title "Increased production of platelet thromboxane B<sub>2</sub>in non-insulin-dependent diabetes. Relationship to vascular complications" @default.
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- W2167620912 doi "https://doi.org/10.1111/j.1365-2362.1984.tb02092.x" @default.
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