Matches in SemOpenAlex for { <https://semopenalex.org/work/W2167623132> ?p ?o ?g. }
- W2167623132 endingPage "24" @default.
- W2167623132 startingPage "9" @default.
- W2167623132 abstract "Extended release formulations of isosorbide mononitrate (IMN), based on osmotic technology, were developed. Target release profile was selected and different variables were optimized to achieve the same. Formulation variables like type (PVP, PEG-4000, and HPMC) and level of pore former (0-55%, w/w of polymer), percent weight gain were found to affect the drug release from the developed formulations. Drug release was inversely proportional to the membrane weight but directly related to the initial level of pore former in the membrane. Burst strength of the exhausted shells was inversely proportional to the level of pore former, but directly affected by the membrane weight. Satisfactory burst strength (more than 320 g) was obtained when PVP was used as pore former (up to 55%, w/w of polymer) at the membrane weight of 7.5% and more. The release from the developed formulations was independent of pH and agitational intensity, but dependent on the osmotic pressure of the release media. Results of SEM studies showed the formation of pores in the membrane from where the drug release occurred. The formulations were found to be stable after 3 months of accelerated stability studies. Prediction of steady-state levels showed the plasma concentrations of IMN to be within the desired range." @default.
- W2167623132 created "2016-06-24" @default.
- W2167623132 creator A5058279304 @default.
- W2167623132 date "2003-09-16" @default.
- W2167623132 modified "2023-10-17" @default.
- W2167623132 title "Development and evaluation of extended release formulations of isosorbide mononitrate based on osmotic technology" @default.
- W2167623132 cites W117083678 @default.
- W2167623132 cites W1525837605 @default.
- W2167623132 cites W1965234424 @default.
- W2167623132 cites W1970452903 @default.
- W2167623132 cites W1978190541 @default.
- W2167623132 cites W1979871046 @default.
- W2167623132 cites W1980478077 @default.
- W2167623132 cites W1981300184 @default.
- W2167623132 cites W1986580554 @default.
- W2167623132 cites W1997615096 @default.
- W2167623132 cites W1998333711 @default.
- W2167623132 cites W2006167271 @default.
- W2167623132 cites W2007588789 @default.
- W2167623132 cites W2010373840 @default.
- W2167623132 cites W2013879448 @default.
- W2167623132 cites W2014577678 @default.
- W2167623132 cites W2024610761 @default.
- W2167623132 cites W2026191520 @default.
- W2167623132 cites W2029746869 @default.
- W2167623132 cites W2044109296 @default.
- W2167623132 cites W2050447544 @default.
- W2167623132 cites W2061699303 @default.
- W2167623132 cites W2061816319 @default.
- W2167623132 cites W2062374144 @default.
- W2167623132 cites W2062534138 @default.
- W2167623132 cites W2062810479 @default.
- W2167623132 cites W2077502175 @default.
- W2167623132 cites W2078987964 @default.
- W2167623132 cites W2095337836 @default.
- W2167623132 cites W2096184509 @default.
- W2167623132 cites W2114155660 @default.
- W2167623132 cites W2115439624 @default.
- W2167623132 cites W2147300912 @default.
- W2167623132 cites W2161280500 @default.
- W2167623132 cites W2321473802 @default.
- W2167623132 cites W2343707421 @default.
- W2167623132 cites W2014567015 @default.
- W2167623132 cites W2092100909 @default.
- W2167623132 cites W2517856836 @default.
- W2167623132 doi "https://doi.org/10.1016/s0378-5173(03)00360-0" @default.
- W2167623132 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12954176" @default.
- W2167623132 hasPublicationYear "2003" @default.
- W2167623132 type Work @default.
- W2167623132 sameAs 2167623132 @default.
- W2167623132 citedByCount "53" @default.
- W2167623132 countsByYear W21676231322012 @default.
- W2167623132 countsByYear W21676231322013 @default.
- W2167623132 countsByYear W21676231322014 @default.
- W2167623132 countsByYear W21676231322015 @default.
- W2167623132 countsByYear W21676231322016 @default.
- W2167623132 countsByYear W21676231322017 @default.
- W2167623132 countsByYear W21676231322018 @default.
- W2167623132 countsByYear W21676231322019 @default.
- W2167623132 countsByYear W21676231322020 @default.
- W2167623132 countsByYear W21676231322022 @default.
- W2167623132 countsByYear W21676231322023 @default.
- W2167623132 crossrefType "journal-article" @default.
- W2167623132 hasAuthorship W2167623132A5058279304 @default.
- W2167623132 hasConcept C10138342 @default.
- W2167623132 hasConcept C107511713 @default.
- W2167623132 hasConcept C126322002 @default.
- W2167623132 hasConcept C162324750 @default.
- W2167623132 hasConcept C178790620 @default.
- W2167623132 hasConcept C185592680 @default.
- W2167623132 hasConcept C2778492647 @default.
- W2167623132 hasConcept C41625074 @default.
- W2167623132 hasConcept C43617362 @default.
- W2167623132 hasConcept C521977710 @default.
- W2167623132 hasConcept C54400483 @default.
- W2167623132 hasConcept C55493867 @default.
- W2167623132 hasConcept C71924100 @default.
- W2167623132 hasConcept C9603476 @default.
- W2167623132 hasConceptScore W2167623132C10138342 @default.
- W2167623132 hasConceptScore W2167623132C107511713 @default.
- W2167623132 hasConceptScore W2167623132C126322002 @default.
- W2167623132 hasConceptScore W2167623132C162324750 @default.
- W2167623132 hasConceptScore W2167623132C178790620 @default.
- W2167623132 hasConceptScore W2167623132C185592680 @default.
- W2167623132 hasConceptScore W2167623132C2778492647 @default.
- W2167623132 hasConceptScore W2167623132C41625074 @default.
- W2167623132 hasConceptScore W2167623132C43617362 @default.
- W2167623132 hasConceptScore W2167623132C521977710 @default.
- W2167623132 hasConceptScore W2167623132C54400483 @default.
- W2167623132 hasConceptScore W2167623132C55493867 @default.
- W2167623132 hasConceptScore W2167623132C71924100 @default.
- W2167623132 hasConceptScore W2167623132C9603476 @default.
- W2167623132 hasIssue "1-2" @default.
- W2167623132 hasLocation W21676231321 @default.
- W2167623132 hasLocation W21676231322 @default.
- W2167623132 hasOpenAccess W2167623132 @default.
- W2167623132 hasPrimaryLocation W21676231321 @default.
- W2167623132 hasRelatedWork W1614347000 @default.