FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2167629074> ?p ?o ?g. }

• W2167629074 endingPage "302" @default.
• W2167629074 startingPage "295" @default.
• W2167629074 abstract "Background and objective Increased glutamate concentration in the cerebrospinal fluid has been reported in severely head-injured patients, suggesting that an excessive release of glutamate may be involved in the process of neuronal damage. Ischaemic damage after subdural haematoma has been reported to be reduced by glutamate (N-methyl-D-aspartate: NMDA) receptor antagonists such as dizocilpine and CGS 19755; even though these drugs were given 20–30 min after insult. Excessive release of excitatory amino acids may produce the neural damage after subdural haematoma and NMDA receptor antagonists may become valuable therapeutic drugs. This study compared the effects of ketamine and dizocilpine, on intracranial pressure and histopathological changes after acute subdural haematoma produced by an injection of autologous blood (150 µL) in rats. Methods The control (n = 9), ketamine (n = 9) and dizocilpine (n = 9) groups, respectively, received saline, ketamine (total dose: 210 mg kg−1) or dizocilpine (total dose: 1.0 mg kg−1) from 0.5 to 8 h after acute subdural haematoma. A silicone group (n = 9) had the same volume of silicone injected subdurally. Results The volume of ischaemic damage in the silicone group (1.3 ± 1.2 mm3) was significantly smaller than in the control group (11.9 ± 3.8 mm3). Ketamine and dizocilpine did not increase intracranial pressure. Dizocilpine significantly decreased the volume of ischaemic damage (6.1 ± 3.8 mm3). Ketamine failed to significantly decrease damage (7.8 ± 5.0 mm3). Conclusions These results suggest that the factors elicited by the clotted blood contribute to the ischaemic damage after subdural haematoma, and that the glutamate receptor antagonist dizocilpine reduces the damage, while ketamine shows only a trend reduction of the damage." @default.
• W2167629074 created "2016-06-24" @default.
• W2167629074 creator A5010442242 @default.
• W2167629074 creator A5023016674 @default.
• W2167629074 creator A5023122858 @default.
• W2167629074 creator A5025105840 @default.
• W2167629074 creator A5045947281 @default.
• W2167629074 creator A5055903535 @default.
• W2167629074 date "2001-05-01" @default.
• W2167629074 modified "2023-09-26" @default.
• W2167629074 title "Dizocilpine but not ketamine reduces the volume of ischaemic damage after acute subdural haematoma in the rat" @default.
• W2167629074 cites W1486511185 @default.
• W2167629074 cites W175902741 @default.
• W2167629074 cites W1966355135 @default.
• W2167629074 cites W1979929247 @default.
• W2167629074 cites W1981234599 @default.
• W2167629074 cites W1981661367 @default.
• W2167629074 cites W1991094324 @default.
• W2167629074 cites W1991468303 @default.
• W2167629074 cites W1995056605 @default.
• W2167629074 cites W2005608576 @default.
• W2167629074 cites W2010390599 @default.
• W2167629074 cites W2018445411 @default.
• W2167629074 cites W2026022416 @default.
• W2167629074 cites W2032545494 @default.
• W2167629074 cites W2043987050 @default.
• W2167629074 cites W2046938783 @default.
• W2167629074 cites W2049158024 @default.
• W2167629074 cites W2054933535 @default.
• W2167629074 cites W2061048878 @default.
• W2167629074 cites W2067466761 @default.
• W2167629074 cites W2070515710 @default.
• W2167629074 cites W2072158510 @default.
• W2167629074 cites W2089077858 @default.
• W2167629074 cites W2089795484 @default.
• W2167629074 cites W2120811528 @default.
• W2167629074 cites W2144158778 @default.
• W2167629074 cites W2166487601 @default.
• W2167629074 doi "https://doi.org/10.1046/j.0265-0215.2000.00825.x" @default.
• W2167629074 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11350471" @default.
• W2167629074 hasPublicationYear "2001" @default.
• W2167629074 type Work @default.
• W2167629074 sameAs 2167629074 @default.
• W2167629074 citedByCount "3" @default.
• W2167629074 countsByYear W21676290742019 @default.
• W2167629074 crossrefType "journal-article" @default.
• W2167629074 hasAuthorship W2167629074A5010442242 @default.
• W2167629074 hasAuthorship W2167629074A5023016674 @default.
• W2167629074 hasAuthorship W2167629074A5023122858 @default.
• W2167629074 hasAuthorship W2167629074A5025105840 @default.
• W2167629074 hasAuthorship W2167629074A5045947281 @default.
• W2167629074 hasAuthorship W2167629074A5055903535 @default.
• W2167629074 hasBestOaLocation W21676290741 @default.
• W2167629074 hasConcept C126322002 @default.
• W2167629074 hasConcept C170493617 @default.
• W2167629074 hasConcept C2777836312 @default.
• W2167629074 hasConcept C2780795376 @default.
• W2167629074 hasConcept C2780954326 @default.
• W2167629074 hasConcept C2781458332 @default.
• W2167629074 hasConcept C42219234 @default.
• W2167629074 hasConcept C61174792 @default.
• W2167629074 hasConcept C67018056 @default.
• W2167629074 hasConcept C71924100 @default.
• W2167629074 hasConcept C98274493 @default.
• W2167629074 hasConceptScore W2167629074C126322002 @default.
• W2167629074 hasConceptScore W2167629074C170493617 @default.
• W2167629074 hasConceptScore W2167629074C2777836312 @default.
• W2167629074 hasConceptScore W2167629074C2780795376 @default.
• W2167629074 hasConceptScore W2167629074C2780954326 @default.
• W2167629074 hasConceptScore W2167629074C2781458332 @default.
• W2167629074 hasConceptScore W2167629074C42219234 @default.
• W2167629074 hasConceptScore W2167629074C61174792 @default.
• W2167629074 hasConceptScore W2167629074C67018056 @default.
• W2167629074 hasConceptScore W2167629074C71924100 @default.
• W2167629074 hasConceptScore W2167629074C98274493 @default.
• W2167629074 hasIssue "5" @default.
• W2167629074 hasLocation W21676290741 @default.
• W2167629074 hasLocation W21676290742 @default.
• W2167629074 hasLocation W21676290743 @default.
• W2167629074 hasOpenAccess W2167629074 @default.
• W2167629074 hasPrimaryLocation W21676290741 @default.
• W2167629074 hasRelatedWork W1589787827 @default.
• W2167629074 hasRelatedWork W1870944445 @default.
• W2167629074 hasRelatedWork W1964414573 @default.
• W2167629074 hasRelatedWork W1974108416 @default.
• W2167629074 hasRelatedWork W2039071842 @default.
• W2167629074 hasRelatedWork W2044093121 @default.
• W2167629074 hasRelatedWork W2044950056 @default.
• W2167629074 hasRelatedWork W2054933535 @default.
• W2167629074 hasRelatedWork W2890403333 @default.
• W2167629074 hasRelatedWork W4231748560 @default.
• W2167629074 hasVolume "18" @default.
• W2167629074 isParatext "false" @default.
• W2167629074 isRetracted "false" @default.
• W2167629074 magId "2167629074" @default.
• W2167629074 workType "article" @default.