FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2167629505> ?p ?o ?g. }

• W2167629505 endingPage "692" @default.
• W2167629505 startingPage "684" @default.
• W2167629505 abstract "Based on expert opinion, the global guidelines for management of multidrug-resistant tuberculosis impose lengthy and often poorly tolerated treatments.This observational study evaluates the effectiveness of standardized regimens for patients with proven multidrug-resistant tuberculosis previously untreated with second-line drugs in low-income countries.Consenting patients were sequentially assigned to one of six standardized treatment regimens. Subsequent cohorts were treated with regimens adapted according to results in prior cohorts. The study was designed to minimize failure and default while reducing total treatment duration without increasing relapse frequency.We report the treatment outcome of all patients with laboratory-confirmed, multidrug-resistant tuberculosis enrolled from May 1997 to December 2007. The most effective treatment regimen required a minimum of 9 months of treatment with gatifloxacin, clofazimine, ethambutol, and pyrazinamide throughout the treatment period supplemented by prothionamide, kanamycin, and high-dose isoniazid during an intensive phase of a minimum of 4 months, giving a relapse-free cure of 87.9% (95% confidence interval, 82.7-91.6) among 206 patients. Major adverse drug reactions were infrequent and manageable. Compared with the 221 patients treated with regimens based on ofloxacin and commonly prothionamide throughout, the hazard ratio of any adverse outcome was 0.39 (95% confidence interval, 0.26-0.59).Serial regimen formulation guided by overall treatment effectiveness resulted in treatment outcomes comparable to those obtained with first-line treatment. Confirmatory formal trials in populations with high levels of human immunodeficiency virus coinfection and in populations with a higher initial prevalence of resistance to second-line drugs are required." @default.
• W2167629505 created "2016-06-24" @default.
• W2167629505 creator A5012768211 @default.
• W2167629505 creator A5026780405 @default.
• W2167629505 creator A5047935595 @default.
• W2167629505 creator A5059394729 @default.
• W2167629505 creator A5061920045 @default.
• W2167629505 creator A5079437533 @default.
• W2167629505 creator A5080925841 @default.
• W2167629505 date "2010-09-01" @default.
• W2167629505 modified "2023-10-17" @default.
• W2167629505 title "Short, Highly Effective, and Inexpensive Standardized Treatment of Multidrug-resistant Tuberculosis" @default.
• W2167629505 cites W1965300200 @default.
• W2167629505 cites W1969896605 @default.
• W2167629505 cites W1981511719 @default.
• W2167629505 cites W2016774534 @default.
• W2167629505 cites W2038235454 @default.
• W2167629505 cites W2046205873 @default.
• W2167629505 cites W2050326181 @default.
• W2167629505 cites W2090542083 @default.
• W2167629505 cites W2095281873 @default.
• W2167629505 cites W2112718676 @default.
• W2167629505 cites W2121082250 @default.
• W2167629505 cites W2141946628 @default.
• W2167629505 cites W4242781268 @default.
• W2167629505 cites W4252917926 @default.
• W2167629505 cites W2140344336 @default.
• W2167629505 doi "https://doi.org/10.1164/rccm.201001-0077oc" @default.
• W2167629505 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20442432" @default.
• W2167629505 hasPublicationYear "2010" @default.
• W2167629505 type Work @default.
• W2167629505 sameAs 2167629505 @default.
• W2167629505 citedByCount "548" @default.
• W2167629505 countsByYear W21676295052012 @default.
• W2167629505 countsByYear W21676295052013 @default.
• W2167629505 countsByYear W21676295052014 @default.
• W2167629505 countsByYear W21676295052015 @default.
• W2167629505 countsByYear W21676295052016 @default.
• W2167629505 countsByYear W21676295052017 @default.
• W2167629505 countsByYear W21676295052018 @default.
• W2167629505 countsByYear W21676295052019 @default.
• W2167629505 countsByYear W21676295052020 @default.
• W2167629505 countsByYear W21676295052021 @default.
• W2167629505 countsByYear W21676295052022 @default.
• W2167629505 countsByYear W21676295052023 @default.
• W2167629505 crossrefType "journal-article" @default.
• W2167629505 hasAuthorship W2167629505A5012768211 @default.
• W2167629505 hasAuthorship W2167629505A5026780405 @default.
• W2167629505 hasAuthorship W2167629505A5047935595 @default.
• W2167629505 hasAuthorship W2167629505A5059394729 @default.
• W2167629505 hasAuthorship W2167629505A5061920045 @default.
• W2167629505 hasAuthorship W2167629505A5079437533 @default.
• W2167629505 hasAuthorship W2167629505A5080925841 @default.
• W2167629505 hasConcept C126322002 @default.
• W2167629505 hasConcept C141071460 @default.
• W2167629505 hasConcept C142724271 @default.
• W2167629505 hasConcept C197934379 @default.
• W2167629505 hasConcept C203014093 @default.
• W2167629505 hasConcept C207103383 @default.
• W2167629505 hasConcept C2776228421 @default.
• W2167629505 hasConcept C2776297342 @default.
• W2167629505 hasConcept C2776301714 @default.
• W2167629505 hasConcept C2776967927 @default.
• W2167629505 hasConcept C2777653605 @default.
• W2167629505 hasConcept C2777768864 @default.
• W2167629505 hasConcept C2778512257 @default.
• W2167629505 hasConcept C2780459521 @default.
• W2167629505 hasConcept C2780695269 @default.
• W2167629505 hasConcept C2781069245 @default.
• W2167629505 hasConcept C2781413609 @default.
• W2167629505 hasConcept C44249647 @default.
• W2167629505 hasConcept C501593827 @default.
• W2167629505 hasConcept C71924100 @default.
• W2167629505 hasConcept C86803240 @default.
• W2167629505 hasConcept C89423630 @default.
• W2167629505 hasConceptScore W2167629505C126322002 @default.
• W2167629505 hasConceptScore W2167629505C141071460 @default.
• W2167629505 hasConceptScore W2167629505C142724271 @default.
• W2167629505 hasConceptScore W2167629505C197934379 @default.
• W2167629505 hasConceptScore W2167629505C203014093 @default.
• W2167629505 hasConceptScore W2167629505C207103383 @default.
• W2167629505 hasConceptScore W2167629505C2776228421 @default.
• W2167629505 hasConceptScore W2167629505C2776297342 @default.
• W2167629505 hasConceptScore W2167629505C2776301714 @default.
• W2167629505 hasConceptScore W2167629505C2776967927 @default.
• W2167629505 hasConceptScore W2167629505C2777653605 @default.
• W2167629505 hasConceptScore W2167629505C2777768864 @default.
• W2167629505 hasConceptScore W2167629505C2778512257 @default.
• W2167629505 hasConceptScore W2167629505C2780459521 @default.
• W2167629505 hasConceptScore W2167629505C2780695269 @default.
• W2167629505 hasConceptScore W2167629505C2781069245 @default.
• W2167629505 hasConceptScore W2167629505C2781413609 @default.
• W2167629505 hasConceptScore W2167629505C44249647 @default.
• W2167629505 hasConceptScore W2167629505C501593827 @default.
• W2167629505 hasConceptScore W2167629505C71924100 @default.
• W2167629505 hasConceptScore W2167629505C86803240 @default.
• W2167629505 hasConceptScore W2167629505C89423630 @default.
• W2167629505 hasIssue "5" @default.

• next