FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2167652900> ?p ?o ?g. }

• W2167652900 endingPage "824" @default.
• W2167652900 startingPage "769" @default.
• W2167652900 abstract "Cyclic nucleotide-gated (CNG) channels are nonselective cation channels first identified in retinal photoreceptors and olfactory sensory neurons (OSNs). They are opened by the direct binding of cyclic nucleotides, cAMP and cGMP. Although their activity shows very little voltage dependence, CNG channels belong to the superfamily of voltage-gated ion channels. Like their cousins the voltage-gated K+ channels, CNG channels form heterotetrameric complexes consisting of two or three different types of subunits. Six different genes encoding CNG channels, four A subunits (A1 to A4) and two B subunits (B1 and B3), give rise to three different channels in rod and cone photoreceptors and in OSNs. Important functional features of these channels, i.e., ligand sensitivity and selectivity, ion permeation, and gating, are determined by the subunit composition of the respective channel complex. The function of CNG channels has been firmly established in retinal photoreceptors and in OSNs. Studies on their presence in other sensory and nonsensory cells have produced mixed results, and their purported roles in neuronal pathfinding or synaptic plasticity are not as well understood as their role in sensory neurons. Similarly, the function of invertebrate homologs found in Caenorhabditis elegans, Drosophila, and Limulus is largely unknown, except for two subunits of C. elegans that play a role in chemosensation. CNG channels are nonselective cation channels that do not discriminate well between alkali ions and even pass divalent cations, in particular Ca2+. Ca2+ entry through CNG channels is important for both excitation and adaptation of sensory cells. CNG channel activity is modulated by Ca2+/calmodulin and by phosphorylation. Other factors may also be involved in channel regulation. Mutations in CNG channel genes give rise to retinal degeneration and color blindness. In particular, mutations in the A and B subunits of the CNG channel expressed in human cones cause various forms of complete and incomplete achromatopsia." @default.
• W2167652900 created "2016-06-24" @default.
• W2167652900 creator A5004950209 @default.
• W2167652900 creator A5058670884 @default.
• W2167652900 date "2002-01-07" @default.
• W2167652900 modified "2023-10-10" @default.
• W2167652900 title "Cyclic Nucleotide-Gated Ion Channels" @default.
• W2167652900 cites W1482197265 @default.
• W2167652900 cites W1496131947 @default.
• W2167652900 cites W1508376267 @default.
• W2167652900 cites W1509440531 @default.
• W2167652900 cites W1524412093 @default.
• W2167652900 cites W1526922448 @default.
• W2167652900 cites W1544329852 @default.
• W2167652900 cites W1544860128 @default.
• W2167652900 cites W1551182340 @default.
• W2167652900 cites W1552908032 @default.
• W2167652900 cites W1563310899 @default.
• W2167652900 cites W1564717701 @default.
• W2167652900 cites W1567110775 @default.
• W2167652900 cites W1576313910 @default.
• W2167652900 cites W1582317529 @default.
• W2167652900 cites W1595603700 @default.
• W2167652900 cites W1603516579 @default.
• W2167652900 cites W1605701068 @default.
• W2167652900 cites W1605987071 @default.
• W2167652900 cites W1624926237 @default.
• W2167652900 cites W1625946078 @default.
• W2167652900 cites W1626052863 @default.
• W2167652900 cites W1642445429 @default.
• W2167652900 cites W1643706501 @default.
• W2167652900 cites W1647778478 @default.
• W2167652900 cites W1650011925 @default.
• W2167652900 cites W1671361404 @default.
• W2167652900 cites W1676740452 @default.
• W2167652900 cites W1678317167 @default.
• W2167652900 cites W176987637 @default.
• W2167652900 cites W1799877731 @default.
• W2167652900 cites W1823259151 @default.
• W2167652900 cites W1835134358 @default.
• W2167652900 cites W1869075740 @default.
• W2167652900 cites W1885709862 @default.
• W2167652900 cites W1895908349 @default.
• W2167652900 cites W1939184057 @default.
• W2167652900 cites W1947481567 @default.
• W2167652900 cites W1950894243 @default.
• W2167652900 cites W1956148136 @default.
• W2167652900 cites W1956651067 @default.
• W2167652900 cites W1963653553 @default.
• W2167652900 cites W1963924076 @default.
• W2167652900 cites W1964253397 @default.
• W2167652900 cites W1964674454 @default.
• W2167652900 cites W1965602055 @default.
• W2167652900 cites W1966001834 @default.
• W2167652900 cites W1966276097 @default.
• W2167652900 cites W1966497392 @default.
• W2167652900 cites W1966616037 @default.
• W2167652900 cites W1966631841 @default.
• W2167652900 cites W1967425088 @default.
• W2167652900 cites W1968333334 @default.
• W2167652900 cites W1968901680 @default.
• W2167652900 cites W1969167133 @default.
• W2167652900 cites W1969540269 @default.
• W2167652900 cites W1969545612 @default.
• W2167652900 cites W1969677318 @default.
• W2167652900 cites W1969789910 @default.
• W2167652900 cites W1970706920 @default.
• W2167652900 cites W1971712681 @default.
• W2167652900 cites W1972334416 @default.
• W2167652900 cites W1972662343 @default.
• W2167652900 cites W1972920546 @default.
• W2167652900 cites W1973042031 @default.
• W2167652900 cites W1973064936 @default.
• W2167652900 cites W1973390482 @default.
• W2167652900 cites W1973875627 @default.
• W2167652900 cites W1974067075 @default.
• W2167652900 cites W1974112901 @default.
• W2167652900 cites W1974191268 @default.
• W2167652900 cites W1975257279 @default.
• W2167652900 cites W1975990281 @default.
• W2167652900 cites W1976320202 @default.
• W2167652900 cites W1976429047 @default.
• W2167652900 cites W1977331102 @default.
• W2167652900 cites W1978498030 @default.
• W2167652900 cites W1979165244 @default.
• W2167652900 cites W1979615372 @default.
• W2167652900 cites W1979694517 @default.
• W2167652900 cites W1981131515 @default.
• W2167652900 cites W1981165639 @default.
• W2167652900 cites W1981670551 @default.
• W2167652900 cites W1982336887 @default.
• W2167652900 cites W1982651256 @default.
• W2167652900 cites W1983183071 @default.
• W2167652900 cites W1983556937 @default.
• W2167652900 cites W1983698424 @default.
• W2167652900 cites W1984139424 @default.
• W2167652900 cites W1986206639 @default.
• W2167652900 cites W1986393620 @default.

• next