FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2167664841> ?p ?o ?g. }

• W2167664841 endingPage "1003" @default.
• W2167664841 startingPage "993" @default.
• W2167664841 abstract "Circulating tumor cells (CTC) might function as early markers for breast cancer metastasis or monitoring therapy efficacy. Enrichment and identification of CTCs are based on epithelial markers that might be modulated during epithelial-mesenchymal transition. Little is known about the expression of keratins in CTCs and whether all CTCs can be detected with antibodies directed against a limited panel of keratins.Protein expression of keratin 2, 4-10, 13-16, 18, and 19 were assessed by a cocktail of antibodies (C11, AE1, AE3, and K7) and keratin antibodies C11 and A45-B/B3 alone in 11 breast cancer cell lines and 50 primary breast carcinomas and their lymph node metastases. Furthermore, CTCs were assessed in blood of 70 metastatic breast cancer patients.Claudin-low cell lines did not show expression of normal breast epithelial keratins but were positive for K14 and K16, detected by the cocktail only. Primary breast carcinomas showed changes in keratin expression during metastatic progression to the lymph nodes. In 35 of 70 patients CTCs were identified, of which 83%, 40%, and 57% were identified by the cocktail, C11 and A45-B/B3, respectively. Identification of CTCs by the cocktail was associated with shorter survival (P < 0.01). In silico analyses revealed association between KRT16 expression and shorter relapse-free survival in metastatic breast cancer.Breast cancer cells show a complex pattern of keratin expression with potential biologic relevance. Individual keratin antibodies recognizing only a limited set of keratins inherit the risk to miss biologically relevant CTCs in cancer patients, and antibody cocktails including these keratins are therefore recommended." @default.
• W2167664841 created "2016-06-24" @default.
• W2167664841 creator A5008875543 @default.
• W2167664841 creator A5048105827 @default.
• W2167664841 creator A5049729464 @default.
• W2167664841 creator A5057850542 @default.
• W2167664841 creator A5061208293 @default.
• W2167664841 creator A5066113397 @default.
• W2167664841 creator A5088637879 @default.
• W2167664841 date "2012-02-14" @default.
• W2167664841 modified "2023-10-14" @default.
• W2167664841 title "Changes in Keratin Expression during Metastatic Progression of Breast Cancer: Impact on the Detection of Circulating Tumor Cells" @default.
• W2167664841 cites W1968467528 @default.
• W2167664841 cites W1969313371 @default.
• W2167664841 cites W1980299983 @default.
• W2167664841 cites W1990120645 @default.
• W2167664841 cites W1991937007 @default.
• W2167664841 cites W2014476767 @default.
• W2167664841 cites W2015652631 @default.
• W2167664841 cites W2016356101 @default.
• W2167664841 cites W2026037933 @default.
• W2167664841 cites W2031735145 @default.
• W2167664841 cites W2035657491 @default.
• W2167664841 cites W2040914426 @default.
• W2167664841 cites W2057151160 @default.
• W2167664841 cites W2060661888 @default.
• W2167664841 cites W2062187838 @default.
• W2167664841 cites W2063140987 @default.
• W2167664841 cites W2068503417 @default.
• W2167664841 cites W2070291618 @default.
• W2167664841 cites W2086794219 @default.
• W2167664841 cites W2106292881 @default.
• W2167664841 cites W2111976640 @default.
• W2167664841 cites W2140551998 @default.
• W2167664841 cites W2142739240 @default.
• W2167664841 cites W2146678830 @default.
• W2167664841 cites W2151451140 @default.
• W2167664841 cites W2155377949 @default.
• W2167664841 cites W2156491034 @default.
• W2167664841 cites W2156734818 @default.
• W2167664841 cites W2159770815 @default.
• W2167664841 cites W2161514295 @default.
• W2167664841 cites W2163563958 @default.
• W2167664841 cites W2166428176 @default.
• W2167664841 cites W2321753125 @default.
• W2167664841 doi "https://doi.org/10.1158/1078-0432.ccr-11-2100" @default.
• W2167664841 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22228641" @default.
• W2167664841 hasPublicationYear "2012" @default.
• W2167664841 type Work @default.
• W2167664841 sameAs 2167664841 @default.
• W2167664841 citedByCount "129" @default.
• W2167664841 countsByYear W21676648412012 @default.
• W2167664841 countsByYear W21676648412013 @default.
• W2167664841 countsByYear W21676648412014 @default.
• W2167664841 countsByYear W21676648412015 @default.
• W2167664841 countsByYear W21676648412016 @default.
• W2167664841 countsByYear W21676648412017 @default.
• W2167664841 countsByYear W21676648412018 @default.
• W2167664841 countsByYear W21676648412019 @default.
• W2167664841 countsByYear W21676648412020 @default.
• W2167664841 countsByYear W21676648412021 @default.
• W2167664841 countsByYear W21676648412022 @default.
• W2167664841 countsByYear W21676648412023 @default.
• W2167664841 crossrefType "journal-article" @default.
• W2167664841 hasAuthorship W2167664841A5008875543 @default.
• W2167664841 hasAuthorship W2167664841A5048105827 @default.
• W2167664841 hasAuthorship W2167664841A5049729464 @default.
• W2167664841 hasAuthorship W2167664841A5057850542 @default.
• W2167664841 hasAuthorship W2167664841A5061208293 @default.
• W2167664841 hasAuthorship W2167664841A5066113397 @default.
• W2167664841 hasAuthorship W2167664841A5088637879 @default.
• W2167664841 hasBestOaLocation W21676648412 @default.
• W2167664841 hasConcept C118646709 @default.
• W2167664841 hasConcept C121608353 @default.
• W2167664841 hasConcept C126322002 @default.
• W2167664841 hasConcept C142724271 @default.
• W2167664841 hasConcept C159654299 @default.
• W2167664841 hasConcept C203014093 @default.
• W2167664841 hasConcept C2775930923 @default.
• W2167664841 hasConcept C2779013556 @default.
• W2167664841 hasConcept C2780849966 @default.
• W2167664841 hasConcept C502942594 @default.
• W2167664841 hasConcept C50548948 @default.
• W2167664841 hasConcept C530470458 @default.
• W2167664841 hasConcept C61238886 @default.
• W2167664841 hasConcept C71924100 @default.
• W2167664841 hasConcept C81241287 @default.
• W2167664841 hasConcept C86803240 @default.
• W2167664841 hasConceptScore W2167664841C118646709 @default.
• W2167664841 hasConceptScore W2167664841C121608353 @default.
• W2167664841 hasConceptScore W2167664841C126322002 @default.
• W2167664841 hasConceptScore W2167664841C142724271 @default.
• W2167664841 hasConceptScore W2167664841C159654299 @default.
• W2167664841 hasConceptScore W2167664841C203014093 @default.
• W2167664841 hasConceptScore W2167664841C2775930923 @default.
• W2167664841 hasConceptScore W2167664841C2779013556 @default.
• W2167664841 hasConceptScore W2167664841C2780849966 @default.
• W2167664841 hasConceptScore W2167664841C502942594 @default.

• next