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• W2167669992 abstract "Objectives Assessment of proliferation by the Ki‐67 labelling index ( K i67‐ LI ) is an important parameter of pancreatic neuroendocrine tumour ( pNET ) prognosis on resection specimens. K i67‐ LI values for grading are not fully established on endoscopic ultrasound‐guided fine needle aspiration ( EUS ‐ FNA ). The aim of the study was to determine the accuracy of K i67‐ LI on EUS ‐ FNA to predict a final grade of p NET and to analyse the relationship between cytological grading and progression‐free survival ( PFS ). Methods Between 1996 and 2010, 46 pNETs (33 were resected) from 45 patients were diagnosed by EUS ‐ FNA . Ki67‐LI was evaluated on cytological and histological material for each tumour and classified according to the 2010 WHO grading system. Results A very good inter‐observer agreement for K i67‐ LI on EUS ‐ FNA and surgical specimens, respectively, were obtained. Discrepancies were observed between histology and cytology, especially in grade 2 ( G 2) tumours, where cytology underestimated grading owing to tumour heterogeneity. Still, EUS ‐ FNA was able to distinguish a poor prognostic group, as the actuarial PFS of cytological (c) G3 tumours was 10 ± 4 months versus 29 ± 7 and 68 ± 10 for c G 2 and c G 1 tumours, respectively ( P < 0.0001). Conclusion This study attests the reproducibility of K i67‐ LI of pNET s whether counted on cytology or histology with a very good inter‐observer correlation. Determination of K i67‐ LI on EUS ‐ FNA of pNETs should be included systematically in their prognostic work‐up." @default.
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• W2167669992 date "2013-11-15" @default.
• W2167669992 modified "2023-10-18" @default.
• W2167669992 title "Pancreatic neuroendocrine tumour grading on endoscopic ultrasound‐guided fine needle aspiration: high reproducibility and inter‐observer agreement of the <scp>K</scp>i‐67 labelling index" @default.
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• W2167669992 doi "https://doi.org/10.1111/cyt.12111" @default.
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