FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2167675897> ?p ?o ?g. }

• W2167675897 endingPage "466" @default.
• W2167675897 startingPage "457" @default.
• W2167675897 abstract "We have previously reported that ES-62, a molecule secreted by the parasitic filarial nematode Acanthocheilonema viteae, protects mice from developing collagen-induced arthritis (CIA). Together with increasing evidence that worm infection may protect against autoimmune conditions, this raises the possibility that ES-62 may have therapeutic potential in rheumatoid arthritis and hence, it is important to fully understand its mechanism of action. To this end, we have established to date that ES-62 protection in CIA is associated with suppressed T helper type 1 (Th1)/Th17 responses, reduced collagen-specific IgG2a antibodies and increased interleukin-10 (IL-10) production by splenocytes. IL-10-producing regulatory B cells have been proposed to suppress pathogenic Th1/Th17 responses in CIA: interestingly therefore, although the levels of IL-10-producing B cells were decreased in the spleens of mice with CIA, ES-62 was found to restore these to the levels found in naive mice. In addition, exposure to ES-62 decreased effector B-cell, particularly plasma cell, infiltration of the joints, and such infiltrating B cells showed dramatically reduced levels of Toll-like receptor 4 and the activation markers, CD80 and CD86. Collectively, this induction of hyporesponsiveness of effector B-cell responses, in the context of the resetting of the levels of IL-10-producing B cells, is suggestive of a modulation of the balance between effector and regulatory B-cell responses that may contribute to ES-62-mediated suppression of CIA-associated inflammation and inhibition of production of pathogenic collagen-specific IgG2a antibodies." @default.
• W2167675897 created "2016-06-24" @default.
• W2167675897 creator A5038174128 @default.
• W2167675897 creator A5039698464 @default.
• W2167675897 creator A5045616871 @default.
• W2167675897 creator A5085073120 @default.
• W2167675897 creator A5087113834 @default.
• W2167675897 creator A5091177745 @default.
• W2167675897 date "2014-02-10" @default.
• W2167675897 modified "2023-09-27" @default.
• W2167675897 title "Protection against collagen-induced arthritis in mice afforded by the parasitic worm product, ES-62, is associated with restoration of the levels of interleukin-10-producing B cells and reduced plasma cell infiltration of the joints" @default.
• W2167675897 cites W1504328662 @default.
• W2167675897 cites W1594052170 @default.
• W2167675897 cites W1641010283 @default.
• W2167675897 cites W1691235385 @default.
• W2167675897 cites W1781404721 @default.
• W2167675897 cites W1882149925 @default.
• W2167675897 cites W1935840505 @default.
• W2167675897 cites W1963701987 @default.
• W2167675897 cites W1968712129 @default.
• W2167675897 cites W1969122689 @default.
• W2167675897 cites W1976891148 @default.
• W2167675897 cites W1978386279 @default.
• W2167675897 cites W1983899969 @default.
• W2167675897 cites W1998494804 @default.
• W2167675897 cites W2000326189 @default.
• W2167675897 cites W2003766274 @default.
• W2167675897 cites W2023502808 @default.
• W2167675897 cites W2037250871 @default.
• W2167675897 cites W2040283985 @default.
• W2167675897 cites W2043106142 @default.
• W2167675897 cites W2043937927 @default.
• W2167675897 cites W2046269603 @default.
• W2167675897 cites W2047503557 @default.
• W2167675897 cites W2053889945 @default.
• W2167675897 cites W2069123765 @default.
• W2167675897 cites W2075646349 @default.
• W2167675897 cites W2081328751 @default.
• W2167675897 cites W2088328410 @default.
• W2167675897 cites W2091664929 @default.
• W2167675897 cites W2092713406 @default.
• W2167675897 cites W2094871488 @default.
• W2167675897 cites W2098412041 @default.
• W2167675897 cites W2101010293 @default.
• W2167675897 cites W2101974006 @default.
• W2167675897 cites W2103496672 @default.
• W2167675897 cites W2104125935 @default.
• W2167675897 cites W2108087703 @default.
• W2167675897 cites W2111687223 @default.
• W2167675897 cites W2123665246 @default.
• W2167675897 cites W2128751441 @default.
• W2167675897 cites W2134493337 @default.
• W2167675897 cites W2134939208 @default.
• W2167675897 cites W2136490822 @default.
• W2167675897 cites W2140014624 @default.
• W2167675897 cites W2140821709 @default.
• W2167675897 cites W2141927730 @default.
• W2167675897 cites W2146904648 @default.
• W2167675897 cites W2148827388 @default.
• W2167675897 cites W2157488005 @default.
• W2167675897 cites W2168516002 @default.
• W2167675897 cites W2170857080 @default.
• W2167675897 cites W2171571685 @default.
• W2167675897 cites W2397929769 @default.
• W2167675897 cites W2414979380 @default.
• W2167675897 doi "https://doi.org/10.1111/imm.12208" @default.
• W2167675897 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3930382" @default.
• W2167675897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24708419" @default.
• W2167675897 hasPublicationYear "2014" @default.
• W2167675897 type Work @default.
• W2167675897 sameAs 2167675897 @default.
• W2167675897 citedByCount "42" @default.
• W2167675897 countsByYear W21676758972014 @default.
• W2167675897 countsByYear W21676758972015 @default.
• W2167675897 countsByYear W21676758972016 @default.
• W2167675897 countsByYear W21676758972017 @default.
• W2167675897 countsByYear W21676758972018 @default.
• W2167675897 countsByYear W21676758972019 @default.
• W2167675897 countsByYear W21676758972020 @default.
• W2167675897 countsByYear W21676758972021 @default.
• W2167675897 countsByYear W21676758972022 @default.
• W2167675897 countsByYear W21676758972023 @default.
• W2167675897 crossrefType "journal-article" @default.
• W2167675897 hasAuthorship W2167675897A5038174128 @default.
• W2167675897 hasAuthorship W2167675897A5039698464 @default.
• W2167675897 hasAuthorship W2167675897A5045616871 @default.
• W2167675897 hasAuthorship W2167675897A5085073120 @default.
• W2167675897 hasAuthorship W2167675897A5087113834 @default.
• W2167675897 hasAuthorship W2167675897A5091177745 @default.
• W2167675897 hasBestOaLocation W21676758971 @default.
• W2167675897 hasConcept C154317977 @default.
• W2167675897 hasConcept C159654299 @default.
• W2167675897 hasConcept C187316574 @default.
• W2167675897 hasConcept C202751555 @default.
• W2167675897 hasConcept C203014093 @default.
• W2167675897 hasConcept C2776090121 @default.
• W2167675897 hasConcept C2776914184 @default.
• W2167675897 hasConcept C2777077863 @default.

• next