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- W2167680069 abstract "As more high-risk hypertensives are treated and the need for more intensive antihypertensive therapy is recognized, combination therapies are increasingly used. For initial therapy, particularly for relatively low-risk patients, low-dose combinations are often appropriate. For those who require additional therapy, higher doses of combinations may provide further efficacy while minimizing dose-dependent side effects of monotherapy, thereby improving adherence to therapy. Those combination agents should provide 24-h control with one daily dose, thereby ensuring protection in the early morning hours. Combining an angiotensin converting enzyme inhibitor and a calcium channel blocker is a rational approach to treating hypertension. Not only does it provide significantly better blood pressure control than individual components used as monotherapy, it also minimizes dose-dependent side effects. Also, combining agents from different classes results in complementary mechanisms of action that provide other cardiovascular protective benefits." @default.
- W2167680069 created "2016-06-24" @default.
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- W2167680069 date "2001-11-01" @default.
- W2167680069 modified "2023-09-23" @default.
- W2167680069 title "Low-dose combination therapy: The rationalization for an ace inhibitor and a calcium channel blocker in higher risk patients" @default.
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- W2167680069 doi "https://doi.org/10.1016/s0895-7061(01)01315-2" @default.
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