FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2167686263> ?p ?o ?g. }

• W2167686263 endingPage "1978" @default.
• W2167686263 startingPage "1967" @default.
• W2167686263 abstract "The COP9 signalosome (CSN) was originally identified based on the constitutively photomorphogenic/de-etiolated/fusca (cop/det/fus) mutants from Arabidopsis thaliana. CSN is evolutionary conserved, and its subunit 5 (CSN5) mediates the deconjugation of NEDD8 from the cullin subunit of E3 ubiquitin ligases (deneddylation). Here, we report on Arabidopsis mutants deficient in CSN5 function. We show that these mutants are phenotypically indistinguishable from the previously described cop/det/fus mutants of other CSN subunits. However, we also show that these mutants retain the CSN complex (lacking CSN5), and this finding is in contrast with the previously described CSN subunit mutants, which lack the CSN complex. We therefore conclude that loss of CSN5 as part of CSN is sufficient to cause the cop/det/fus mutant phenotype. Furthermore, we show that mutants defective in CSN5 as well as mutants defective in CSN are unable to deneddylate the Arabidopsis cullins AtCUL1, AtCUL3A, and AtCUL4. Because these are representative cullin subunits of the three cullin-containing E3 families present in Arabidopsis, we postulate that the cop/det/fus mutant phenotype may be the result of the defects caused by impaired CSN5-dependent deneddylation of cullin-containing E3s." @default.
• W2167686263 created "2016-06-24" @default.
• W2167686263 creator A5002589790 @default.
• W2167686263 creator A5048605661 @default.
• W2167686263 creator A5055776595 @default.
• W2167686263 date "2005-05-27" @default.
• W2167686263 modified "2023-09-27" @default.
• W2167686263 title "Loss of the CONSTITUTIVE PHOTOMORPHOGENIC9 Signalosome Subunit 5 Is Sufficient to Cause the <i>cop</i>/<i>det</i>/<i>fus</i> Mutant Phenotype in Arabidopsis" @default.
• W2167686263 cites W1665182114 @default.
• W2167686263 cites W1937783148 @default.
• W2167686263 cites W1966522270 @default.
• W2167686263 cites W1978878131 @default.
• W2167686263 cites W1980447284 @default.
• W2167686263 cites W1981089845 @default.
• W2167686263 cites W1981126988 @default.
• W2167686263 cites W1985715181 @default.
• W2167686263 cites W1986987419 @default.
• W2167686263 cites W1989088998 @default.
• W2167686263 cites W1993969626 @default.
• W2167686263 cites W1999466865 @default.
• W2167686263 cites W2003062513 @default.
• W2167686263 cites W2009781189 @default.
• W2167686263 cites W2013057562 @default.
• W2167686263 cites W2014069479 @default.
• W2167686263 cites W2018552032 @default.
• W2167686263 cites W2046510462 @default.
• W2167686263 cites W2053763318 @default.
• W2167686263 cites W2056052347 @default.
• W2167686263 cites W2060913542 @default.
• W2167686263 cites W2064996932 @default.
• W2167686263 cites W2068652435 @default.
• W2167686263 cites W2070204151 @default.
• W2167686263 cites W2080650795 @default.
• W2167686263 cites W2085594745 @default.
• W2167686263 cites W2086187252 @default.
• W2167686263 cites W2092321617 @default.
• W2167686263 cites W2096262442 @default.
• W2167686263 cites W2098115340 @default.
• W2167686263 cites W2099099804 @default.
• W2167686263 cites W2103539812 @default.
• W2167686263 cites W2103981938 @default.
• W2167686263 cites W2105618655 @default.
• W2167686263 cites W2108366666 @default.
• W2167686263 cites W2109356345 @default.
• W2167686263 cites W2109446031 @default.
• W2167686263 cites W2110164855 @default.
• W2167686263 cites W2112528524 @default.
• W2167686263 cites W2115225191 @default.
• W2167686263 cites W2115431543 @default.
• W2167686263 cites W2123107434 @default.
• W2167686263 cites W2124938253 @default.
• W2167686263 cites W2129473323 @default.
• W2167686263 cites W2134176459 @default.
• W2167686263 cites W2141329235 @default.
• W2167686263 cites W2147078386 @default.
• W2167686263 cites W2147882459 @default.
• W2167686263 cites W2149171261 @default.
• W2167686263 cites W2150431323 @default.
• W2167686263 cites W2151825126 @default.
• W2167686263 cites W2155056424 @default.
• W2167686263 cites W2157057002 @default.
• W2167686263 cites W2157982286 @default.
• W2167686263 cites W2162669867 @default.
• W2167686263 cites W2166987747 @default.
• W2167686263 cites W2167894564 @default.
• W2167686263 cites W2168459388 @default.
• W2167686263 cites W2168915005 @default.
• W2167686263 cites W2170634115 @default.
• W2167686263 doi "https://doi.org/10.1105/tpc.105.032870" @default.
• W2167686263 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1167545" @default.
• W2167686263 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15923347" @default.
• W2167686263 hasPublicationYear "2005" @default.
• W2167686263 type Work @default.
• W2167686263 sameAs 2167686263 @default.
• W2167686263 citedByCount "89" @default.
• W2167686263 countsByYear W21676862632012 @default.
• W2167686263 countsByYear W21676862632013 @default.
• W2167686263 countsByYear W21676862632014 @default.
• W2167686263 countsByYear W21676862632015 @default.
• W2167686263 countsByYear W21676862632016 @default.
• W2167686263 countsByYear W21676862632017 @default.
• W2167686263 countsByYear W21676862632018 @default.
• W2167686263 countsByYear W21676862632019 @default.
• W2167686263 countsByYear W21676862632020 @default.
• W2167686263 countsByYear W21676862632021 @default.
• W2167686263 countsByYear W21676862632022 @default.
• W2167686263 crossrefType "journal-article" @default.
• W2167686263 hasAuthorship W2167686263A5002589790 @default.
• W2167686263 hasAuthorship W2167686263A5048605661 @default.
• W2167686263 hasAuthorship W2167686263A5055776595 @default.
• W2167686263 hasBestOaLocation W21676862631 @default.
• W2167686263 hasConcept C104292427 @default.
• W2167686263 hasConcept C104317684 @default.
• W2167686263 hasConcept C127716648 @default.
• W2167686263 hasConcept C134459356 @default.
• W2167686263 hasConcept C143065580 @default.
• W2167686263 hasConcept C181199279 @default.
• W2167686263 hasConcept C25602115 @default.

• next