FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2167728305> ?p ?o ?g. }

• W2167728305 endingPage "L941" @default.
• W2167728305 startingPage "L924" @default.
• W2167728305 abstract "Pulmonary hypertension (PH) is characterized by elevated pulmonary arterial pressure leading to right-sided heart failure and can arise from a wide range of etiologies. The most common cause of PH, termed Group 2 PH, is left-sided heart failure and is commonly known as pulmonary hypertension with left heart disease (PH-LHD). Importantly, while sharing many clinical features with pulmonary arterial hypertension (PAH), PH-LHD differs significantly at the cellular and physiological levels. These fundamental pathophysiological differences largely account for the poor response to PAH therapies experienced by PH-LHD patients. The relatively high prevalence of this disease, coupled with its unique features compared with PAH, signal the importance of an in-depth understanding of the mechanistic details of PH-LHD. The present review will focus on the current state of knowledge regarding the pathomechanisms of PH-LHD, highlighting work carried out both in human trials and in preclinical animal models. Adaptive processes at the alveolocapillary barrier and in the pulmonary circulation, including alterations in alveolar fluid transport, endothelial junctional integrity, and vasoactive mediator secretion will be discussed in detail, highlighting the aspects that impact the response to, and development of, novel therapeutics." @default.
• W2167728305 created "2016-06-24" @default.
• W2167728305 creator A5009101111 @default.
• W2167728305 creator A5011265113 @default.
• W2167728305 creator A5047245168 @default.
• W2167728305 creator A5052156769 @default.
• W2167728305 date "2015-11-01" @default.
• W2167728305 modified "2023-10-05" @default.
• W2167728305 title "The pathophysiology of pulmonary hypertension in left heart disease" @default.
• W2167728305 cites W114168622 @default.
• W2167728305 cites W120579310 @default.
• W2167728305 cites W122121821 @default.
• W2167728305 cites W128823384 @default.
• W2167728305 cites W1537647993 @default.
• W2167728305 cites W1609671577 @default.
• W2167728305 cites W1770674522 @default.
• W2167728305 cites W1926326792 @default.
• W2167728305 cites W1968650507 @default.
• W2167728305 cites W1969448383 @default.
• W2167728305 cites W1975701792 @default.
• W2167728305 cites W1977354362 @default.
• W2167728305 cites W1979363352 @default.
• W2167728305 cites W1981334350 @default.
• W2167728305 cites W1985705946 @default.
• W2167728305 cites W1986060795 @default.
• W2167728305 cites W1986484438 @default.
• W2167728305 cites W1987412660 @default.
• W2167728305 cites W1989086240 @default.
• W2167728305 cites W1991477995 @default.
• W2167728305 cites W1991994719 @default.
• W2167728305 cites W1992983801 @default.
• W2167728305 cites W1993580604 @default.
• W2167728305 cites W1995915139 @default.
• W2167728305 cites W1999150579 @default.
• W2167728305 cites W1999975100 @default.
• W2167728305 cites W2001207343 @default.
• W2167728305 cites W2001252757 @default.
• W2167728305 cites W2002339710 @default.
• W2167728305 cites W2003150221 @default.
• W2167728305 cites W2003257177 @default.
• W2167728305 cites W2004535991 @default.
• W2167728305 cites W2006273520 @default.
• W2167728305 cites W2007001122 @default.
• W2167728305 cites W2009227641 @default.
• W2167728305 cites W2009618695 @default.
• W2167728305 cites W2010909603 @default.
• W2167728305 cites W2013487212 @default.
• W2167728305 cites W2015066623 @default.
• W2167728305 cites W2015715646 @default.
• W2167728305 cites W2016305001 @default.
• W2167728305 cites W2017086531 @default.
• W2167728305 cites W2018404032 @default.
• W2167728305 cites W2020433703 @default.
• W2167728305 cites W2020724779 @default.
• W2167728305 cites W2021105342 @default.
• W2167728305 cites W2021942340 @default.
• W2167728305 cites W2021971946 @default.
• W2167728305 cites W2022590044 @default.
• W2167728305 cites W2023540223 @default.
• W2167728305 cites W2024102644 @default.
• W2167728305 cites W2026338542 @default.
• W2167728305 cites W2027247941 @default.
• W2167728305 cites W2028148874 @default.
• W2167728305 cites W2029591173 @default.
• W2167728305 cites W2029694692 @default.
• W2167728305 cites W2030396326 @default.
• W2167728305 cites W2033557350 @default.
• W2167728305 cites W2033852098 @default.
• W2167728305 cites W2037930773 @default.
• W2167728305 cites W2038663702 @default.
• W2167728305 cites W2040599383 @default.
• W2167728305 cites W2044261018 @default.
• W2167728305 cites W2046783116 @default.
• W2167728305 cites W2048179019 @default.
• W2167728305 cites W2048443661 @default.
• W2167728305 cites W2049978396 @default.
• W2167728305 cites W2051837714 @default.
• W2167728305 cites W2052483727 @default.
• W2167728305 cites W2053775321 @default.
• W2167728305 cites W2054818418 @default.
• W2167728305 cites W2060795415 @default.
• W2167728305 cites W2061675399 @default.
• W2167728305 cites W2068734467 @default.
• W2167728305 cites W2069981982 @default.
• W2167728305 cites W2072463503 @default.
• W2167728305 cites W2072518222 @default.
• W2167728305 cites W2073467860 @default.
• W2167728305 cites W2073718634 @default.
• W2167728305 cites W2075261463 @default.
• W2167728305 cites W2075941589 @default.
• W2167728305 cites W2077271483 @default.
• W2167728305 cites W2079063592 @default.
• W2167728305 cites W2079941180 @default.
• W2167728305 cites W2080581906 @default.
• W2167728305 cites W2081019211 @default.
• W2167728305 cites W2082226249 @default.
• W2167728305 cites W2084147384 @default.
• W2167728305 cites W2089890078 @default.

• next