Matches in SemOpenAlex for { <https://semopenalex.org/work/W2167780620> ?p ?o ?g. }
- W2167780620 endingPage "1168" @default.
- W2167780620 startingPage "1161" @default.
- W2167780620 abstract "The progressive rise in uterine blood flow during pregnancy is accompanied by outward hypertrophic remodeling of the uterine artery (UA). This process involves changes of the arterial smooth muscle cells and extracellular matrix. Acute increases in blood flow stimulate endothelial production of nitric oxide (NO). It remains to be established whether endothelial NO synthase (eNOS) is involved in pregnancy-related arterial remodeling. We tested the hypothesis that absence of eNOS results in a reduced remodeling capacity of the UA during pregnancy leading to a decline in neonatal outcome. UA of nonpregnant and pregnant wild-type (Nos3+/+) and eNOS-deficient (Nos3-/-) mice were collected and processed for standard morphometrical analyses. In addition, cross sections of UA were processed for cytological (smoothelin, smooth muscle alpha-actin) and proliferation (Ki-67) immunostaining. We compared the pregnancy-related changes longitudinally and, together with the data on pregnancy outcome, transversally by analysis of variance with Bonferroni correction. During pregnancy, the increases in radius and medial cross sectional area of Nos3-/- UA was significantly less than those of Nos3+/+ UA. Smooth muscle cell dedifferentiation and proliferation were impaired in gravid Nos3-/- mice as deduced from the lack of change in the expression of smoothelin and smooth muscle alpha-actin, and the reduced Ki-67 expression. Until 17 days of gestation, litter size did not differ between both genotypes, but at birth the number of viable newborn pups and their weights were smaller in Nos3-/- than in Nos3+/+ mice. We conclude that absence of eNOS adversely affects UA remodeling in pregnancy, which may explain the impaired pregnancy outcome observed in these mice." @default.
- W2167780620 created "2016-06-24" @default.
- W2167780620 creator A5012556000 @default.
- W2167780620 creator A5049359215 @default.
- W2167780620 creator A5049539801 @default.
- W2167780620 creator A5054733061 @default.
- W2167780620 creator A5074301079 @default.
- W2167780620 creator A5078674100 @default.
- W2167780620 date "2005-05-01" @default.
- W2167780620 modified "2023-10-17" @default.
- W2167780620 title "Uterine Artery Remodeling and Reproductive Performance Are Impaired in Endothelial Nitric Oxide Synthase-Deficient Mice1" @default.
- W2167780620 cites W1912592877 @default.
- W2167780620 cites W1936770188 @default.
- W2167780620 cites W1966036045 @default.
- W2167780620 cites W1972789975 @default.
- W2167780620 cites W1973626130 @default.
- W2167780620 cites W1974332277 @default.
- W2167780620 cites W1978904451 @default.
- W2167780620 cites W1979017126 @default.
- W2167780620 cites W1986038688 @default.
- W2167780620 cites W2010842674 @default.
- W2167780620 cites W2023175037 @default.
- W2167780620 cites W2035620169 @default.
- W2167780620 cites W2036389244 @default.
- W2167780620 cites W2038600714 @default.
- W2167780620 cites W2047923246 @default.
- W2167780620 cites W2057740219 @default.
- W2167780620 cites W2058084210 @default.
- W2167780620 cites W2091193879 @default.
- W2167780620 cites W2091499945 @default.
- W2167780620 cites W2093455882 @default.
- W2167780620 cites W2095824482 @default.
- W2167780620 cites W2096728345 @default.
- W2167780620 cites W2098963270 @default.
- W2167780620 cites W2104364881 @default.
- W2167780620 cites W2108747532 @default.
- W2167780620 cites W2112013364 @default.
- W2167780620 cites W2114488399 @default.
- W2167780620 cites W2116527718 @default.
- W2167780620 cites W2118148454 @default.
- W2167780620 cites W2120494123 @default.
- W2167780620 cites W2121319413 @default.
- W2167780620 cites W2124633824 @default.
- W2167780620 cites W2128150118 @default.
- W2167780620 cites W2131039517 @default.
- W2167780620 cites W2134382614 @default.
- W2167780620 cites W2141030191 @default.
- W2167780620 cites W2141860414 @default.
- W2167780620 cites W2142775955 @default.
- W2167780620 cites W2142902360 @default.
- W2167780620 cites W2165107572 @default.
- W2167780620 cites W2167202416 @default.
- W2167780620 cites W2183061178 @default.
- W2167780620 cites W2188466537 @default.
- W2167780620 cites W2203628781 @default.
- W2167780620 cites W2208568497 @default.
- W2167780620 cites W2262423141 @default.
- W2167780620 cites W2338679546 @default.
- W2167780620 cites W3015544325 @default.
- W2167780620 cites W4240196725 @default.
- W2167780620 doi "https://doi.org/10.1095/biolreprod.104.033985" @default.
- W2167780620 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15659709" @default.
- W2167780620 hasPublicationYear "2005" @default.
- W2167780620 type Work @default.
- W2167780620 sameAs 2167780620 @default.
- W2167780620 citedByCount "90" @default.
- W2167780620 countsByYear W21677806202012 @default.
- W2167780620 countsByYear W21677806202013 @default.
- W2167780620 countsByYear W21677806202014 @default.
- W2167780620 countsByYear W21677806202015 @default.
- W2167780620 countsByYear W21677806202016 @default.
- W2167780620 countsByYear W21677806202017 @default.
- W2167780620 countsByYear W21677806202018 @default.
- W2167780620 countsByYear W21677806202019 @default.
- W2167780620 countsByYear W21677806202020 @default.
- W2167780620 countsByYear W21677806202021 @default.
- W2167780620 countsByYear W21677806202022 @default.
- W2167780620 countsByYear W21677806202023 @default.
- W2167780620 crossrefType "journal-article" @default.
- W2167780620 hasAuthorship W2167780620A5012556000 @default.
- W2167780620 hasAuthorship W2167780620A5049359215 @default.
- W2167780620 hasAuthorship W2167780620A5049539801 @default.
- W2167780620 hasAuthorship W2167780620A5054733061 @default.
- W2167780620 hasAuthorship W2167780620A5074301079 @default.
- W2167780620 hasAuthorship W2167780620A5078674100 @default.
- W2167780620 hasBestOaLocation W21677806201 @default.
- W2167780620 hasConcept C126322002 @default.
- W2167780620 hasConcept C134018914 @default.
- W2167780620 hasConcept C16685009 @default.
- W2167780620 hasConcept C2777622882 @default.
- W2167780620 hasConcept C2778326061 @default.
- W2167780620 hasConcept C2779234561 @default.
- W2167780620 hasConcept C2781207646 @default.
- W2167780620 hasConcept C46973012 @default.
- W2167780620 hasConcept C519581460 @default.
- W2167780620 hasConcept C54355233 @default.
- W2167780620 hasConcept C71924100 @default.
- W2167780620 hasConcept C86803240 @default.