FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2167780668> ?p ?o ?g. }

• W2167780668 endingPage "e43" @default.
• W2167780668 startingPage "e43" @default.
• W2167780668 abstract "Multiple myeloma (MM) is a malignant neoplasm of plasma cells. Although new molecular targeting agents against MM have been developed based on the better understanding of the underlying pathogenesis, MM still remains an incurable disease. We previously demonstrated that β-catenin, a downstream effector in the Wnt pathway, is a potential target in MM using RNA interference in an in vivo experimental mouse model. In this study, we have screened a library of more than 100 000 small-molecule chemical compounds for novel Wnt/β-catenin signaling inhibitors using a high-throughput transcriptional screening technology. We identified AV-65, which diminished β-catenin protein levels and T-cell factor transcriptional activity. AV-65 then decreased c-myc, cyclin D1 and survivin expression, resulting in the inhibition of MM cell proliferation through the apoptotic pathway. AV-65 treatment prolonged the survival of MM-bearing mice. These findings indicate that this compound represents a novel and attractive therapeutic agent against MM. This study also illustrates the potential of high-throughput transcriptional screening to identify candidates for anticancer drug discovery." @default.
• W2167780668 created "2016-06-24" @default.
• W2167780668 creator A5001462157 @default.
• W2167780668 creator A5008116172 @default.
• W2167780668 creator A5022260018 @default.
• W2167780668 creator A5025614828 @default.
• W2167780668 creator A5028457340 @default.
• W2167780668 creator A5028603816 @default.
• W2167780668 creator A5035319682 @default.
• W2167780668 creator A5036112859 @default.
• W2167780668 creator A5036766061 @default.
• W2167780668 creator A5038279230 @default.
• W2167780668 creator A5039456378 @default.
• W2167780668 creator A5071371446 @default.
• W2167780668 creator A5073870319 @default.
• W2167780668 creator A5074336736 @default.
• W2167780668 creator A5077867998 @default.
• W2167780668 creator A5081363686 @default.
• W2167780668 creator A5083706118 @default.
• W2167780668 date "2011-11-04" @default.
• W2167780668 modified "2023-10-07" @default.
• W2167780668 title "AV-65, a novel Wnt/β-catenin signal inhibitor, successfully suppresses progression of multiple myeloma in a mouse model" @default.
• W2167780668 cites W1540649941 @default.
• W2167780668 cites W1554815317 @default.
• W2167780668 cites W1967803088 @default.
• W2167780668 cites W1983755269 @default.
• W2167780668 cites W1984534203 @default.
• W2167780668 cites W1985559988 @default.
• W2167780668 cites W1993369755 @default.
• W2167780668 cites W2002404925 @default.
• W2167780668 cites W2002522440 @default.
• W2167780668 cites W2007251848 @default.
• W2167780668 cites W2010552629 @default.
• W2167780668 cites W2010867414 @default.
• W2167780668 cites W2035192365 @default.
• W2167780668 cites W2039708666 @default.
• W2167780668 cites W2042422564 @default.
• W2167780668 cites W2044259020 @default.
• W2167780668 cites W2059198036 @default.
• W2167780668 cites W2063620691 @default.
• W2167780668 cites W2080559728 @default.
• W2167780668 cites W2081985759 @default.
• W2167780668 cites W2091346949 @default.
• W2167780668 cites W2091722004 @default.
• W2167780668 cites W2095715712 @default.
• W2167780668 cites W2097689792 @default.
• W2167780668 cites W2104100666 @default.
• W2167780668 cites W2111566256 @default.
• W2167780668 cites W2112194579 @default.
• W2167780668 cites W2125347681 @default.
• W2167780668 cites W2131730587 @default.
• W2167780668 cites W2135112699 @default.
• W2167780668 cites W2137440275 @default.
• W2167780668 cites W2141451077 @default.
• W2167780668 cites W2146812359 @default.
• W2167780668 cites W2157852756 @default.
• W2167780668 cites W2163320846 @default.
• W2167780668 cites W2169493090 @default.
• W2167780668 doi "https://doi.org/10.1038/bcj.2011.41" @default.
• W2167780668 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3256754" @default.
• W2167780668 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22829079" @default.
• W2167780668 hasPublicationYear "2011" @default.
• W2167780668 type Work @default.
• W2167780668 sameAs 2167780668 @default.
• W2167780668 citedByCount "43" @default.
• W2167780668 countsByYear W21677806682012 @default.
• W2167780668 countsByYear W21677806682013 @default.
• W2167780668 countsByYear W21677806682014 @default.
• W2167780668 countsByYear W21677806682015 @default.
• W2167780668 countsByYear W21677806682016 @default.
• W2167780668 countsByYear W21677806682017 @default.
• W2167780668 countsByYear W21677806682018 @default.
• W2167780668 countsByYear W21677806682019 @default.
• W2167780668 countsByYear W21677806682020 @default.
• W2167780668 countsByYear W21677806682021 @default.
• W2167780668 countsByYear W21677806682022 @default.
• W2167780668 countsByYear W21677806682023 @default.
• W2167780668 crossrefType "journal-article" @default.
• W2167780668 hasAuthorship W2167780668A5001462157 @default.
• W2167780668 hasAuthorship W2167780668A5008116172 @default.
• W2167780668 hasAuthorship W2167780668A5022260018 @default.
• W2167780668 hasAuthorship W2167780668A5025614828 @default.
• W2167780668 hasAuthorship W2167780668A5028457340 @default.
• W2167780668 hasAuthorship W2167780668A5028603816 @default.
• W2167780668 hasAuthorship W2167780668A5035319682 @default.
• W2167780668 hasAuthorship W2167780668A5036112859 @default.
• W2167780668 hasAuthorship W2167780668A5036766061 @default.
• W2167780668 hasAuthorship W2167780668A5038279230 @default.
• W2167780668 hasAuthorship W2167780668A5039456378 @default.
• W2167780668 hasAuthorship W2167780668A5071371446 @default.
• W2167780668 hasAuthorship W2167780668A5073870319 @default.
• W2167780668 hasAuthorship W2167780668A5074336736 @default.
• W2167780668 hasAuthorship W2167780668A5077867998 @default.
• W2167780668 hasAuthorship W2167780668A5081363686 @default.
• W2167780668 hasAuthorship W2167780668A5083706118 @default.
• W2167780668 hasBestOaLocation W21677806681 @default.
• W2167780668 hasConcept C104317684 @default.
• W2167780668 hasConcept C137620995 @default.

• next