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- W2167788333 abstract "Both protein and solid-state nanopores are under intense investigation for the analysis of nucleic acids. A crucial advantage of protein nanopores is that site-directed mutagenesis permits precise tuning of their properties. Here, by augmenting the internal positive charge within the alpha-hemolysin pore and varying its distribution, we increase the frequency of translocation of a 92-nt single-stranded DNA through the pore at +120 mV by approximately 10-fold over the wild-type protein and dramatically lower the voltage threshold at which translocation occurs, e.g., by 50 mV for 1 event.s(-1).muM(-1). Further, events in which DNA enters the pore, but is not immediately translocated, are almost eliminated. These experiments provide a basis for improved nucleic acid analysis with protein nanopores, which might be translated to solid-state nanopores by using chemical surface modification." @default.
- W2167788333 created "2016-06-24" @default.
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- W2167788333 date "2008-12-16" @default.
- W2167788333 modified "2023-10-18" @default.
- W2167788333 title "Enhanced translocation of single DNA molecules through α-hemolysin nanopores by manipulation of internal charge" @default.
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- W2167788333 doi "https://doi.org/10.1073/pnas.0808296105" @default.
- W2167788333 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2604925" @default.
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