FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2167789296> ?p ?o ?g. }

• W2167789296 endingPage "632" @default.
• W2167789296 startingPage "622" @default.
• W2167789296 abstract "ABSTRACT Klebsiella pneumoniae ORI-1 was isolated in 1998 in France from a rectal swab of a 1-month-old girl who was previously hospitalized in Cayenne Hospital, Cayenne, French Guiana. This strain harbored a ca. 140-kb nontransferable plasmid, pTK1, that conferred an extended-spectrum cephalosporin resistance profile antagonized by the addition of clavulanic acid, tazobactam, or imipenem. The gene for GES-1 (Guiana extended-spectrum β-lactamase) was cloned, and its protein was expressed in Escherichia coli DH10B, where this pI-5.8 β-lactamase of a ca. 31-kDa molecular mass conferred resistance to oxyimino cephalosporins (mostly to ceftazidime). GES-1 is weakly related to the other plasmid-located Ambler class A extended-spectrum β-lactamases (ESBLs). The highest percentage of amino acid identity was obtained with the carbenicillinase GN79 from Proteus mirabilis ; with YENT, a chromosome-borne penicillinase from Yersinia enterocolitica ; and with L-2, a chromosome-borne class A cephalosporinase from Stenotrophomonas maltophilia (36% amino acid identity each). However, a dendrogram analysis showed that GES-1 clustered within a class A ESBL subgroup together with ESBLs VEB-1 and PER-1. Sequencing of a 7,098-bp DNA fragment from plasmid pTK1 revealed that the GES-1 gene was located on a novel class 1 integron named In52 that was characterized by (i) a 5′ conserved segment containing an intI1 gene possessing two putative promoters, P 1 and P 2 , for coordinated expression of the downstream antibiotic resistance genes and an attI1 recombination site; (ii) five antibiotic gene cassettes, bla GES-1 , aac(6′)Ib ′ (gentamicin resistance and amikacin susceptibility), dfrXVb (trimethoprim resistance), a novel chloramphenicol resistance gene ( cmlA4 ), and aadA2 (streptomycin-spectinomycin resistance); and (iii) a 3′ conserved segment consisting of qacEΔ1 and sulI . The bla GES-1 and aadA2 gene cassettes were peculiar, since they lacked a typical 59-base element. This work identified the second class A ESBL gene of a non-TEM, non-SHV series which was located in the plasmid and integron, thus providing it additional means for its spread and its expression." @default.
• W2167789296 created "2016-06-24" @default.
• W2167789296 creator A5033280604 @default.
• W2167789296 creator A5034763831 @default.
• W2167789296 creator A5037481164 @default.
• W2167789296 creator A5063393446 @default.
• W2167789296 creator A5087319030 @default.
• W2167789296 date "2000-03-01" @default.
• W2167789296 modified "2023-10-18" @default.
• W2167789296 title "Biochemical Sequence Analyses of GES-1, a Novel Class A Extended-Spectrum β-Lactamase, and the Class 1 Integron In52 from <i>Klebsiella pneumoniae</i>" @default.
• W2167789296 cites W1513431852 @default.
• W2167789296 cites W1576608645 @default.
• W2167789296 cites W1603249345 @default.
• W2167789296 cites W1701997017 @default.
• W2167789296 cites W188730109 @default.
• W2167789296 cites W1897044430 @default.
• W2167789296 cites W1905789354 @default.
• W2167789296 cites W1913562629 @default.
• W2167789296 cites W1971942830 @default.
• W2167789296 cites W1976248938 @default.
• W2167789296 cites W1993400812 @default.
• W2167789296 cites W2001552676 @default.
• W2167789296 cites W2008602286 @default.
• W2167789296 cites W2009045396 @default.
• W2167789296 cites W2013103670 @default.
• W2167789296 cites W2022035303 @default.
• W2167789296 cites W2035657017 @default.
• W2167789296 cites W2040804942 @default.
• W2167789296 cites W2056062475 @default.
• W2167789296 cites W2056357846 @default.
• W2167789296 cites W2059094171 @default.
• W2167789296 cites W2063837892 @default.
• W2167789296 cites W2067472717 @default.
• W2167789296 cites W2076765994 @default.
• W2167789296 cites W2087255376 @default.
• W2167789296 cites W2100837269 @default.
• W2167789296 cites W2109068357 @default.
• W2167789296 cites W2110951528 @default.
• W2167789296 cites W2111968027 @default.
• W2167789296 cites W2115573127 @default.
• W2167789296 cites W2119065304 @default.
• W2167789296 cites W2127732987 @default.
• W2167789296 cites W2130785042 @default.
• W2167789296 cites W2131950041 @default.
• W2167789296 cites W2133676327 @default.
• W2167789296 cites W2134352676 @default.
• W2167789296 cites W2135725736 @default.
• W2167789296 cites W2140193121 @default.
• W2167789296 cites W2141554290 @default.
• W2167789296 cites W2143874510 @default.
• W2167789296 cites W2146148282 @default.
• W2167789296 cites W2146909338 @default.
• W2167789296 cites W2147950657 @default.
• W2167789296 cites W2148298053 @default.
• W2167789296 cites W2149296553 @default.
• W2167789296 cites W2151911135 @default.
• W2167789296 cites W2152256020 @default.
• W2167789296 cites W2154952849 @default.
• W2167789296 cites W2158119633 @default.
• W2167789296 cites W2159294004 @default.
• W2167789296 cites W2160129121 @default.
• W2167789296 cites W2161985926 @default.
• W2167789296 cites W2162825747 @default.
• W2167789296 cites W2168484428 @default.
• W2167789296 cites W2170241141 @default.
• W2167789296 cites W4242135481 @default.
• W2167789296 doi "https://doi.org/10.1128/aac.44.3.622-632.2000" @default.
• W2167789296 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/89737" @default.
• W2167789296 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10681329" @default.
• W2167789296 hasPublicationYear "2000" @default.
• W2167789296 type Work @default.
• W2167789296 sameAs 2167789296 @default.
• W2167789296 citedByCount "393" @default.
• W2167789296 countsByYear W21677892962012 @default.
• W2167789296 countsByYear W21677892962013 @default.
• W2167789296 countsByYear W21677892962014 @default.
• W2167789296 countsByYear W21677892962015 @default.
• W2167789296 countsByYear W21677892962016 @default.
• W2167789296 countsByYear W21677892962017 @default.
• W2167789296 countsByYear W21677892962018 @default.
• W2167789296 countsByYear W21677892962019 @default.
• W2167789296 countsByYear W21677892962020 @default.
• W2167789296 countsByYear W21677892962021 @default.
• W2167789296 countsByYear W21677892962022 @default.
• W2167789296 countsByYear W21677892962023 @default.
• W2167789296 crossrefType "journal-article" @default.
• W2167789296 hasAuthorship W2167789296A5033280604 @default.
• W2167789296 hasAuthorship W2167789296A5034763831 @default.
• W2167789296 hasAuthorship W2167789296A5037481164 @default.
• W2167789296 hasAuthorship W2167789296A5063393446 @default.
• W2167789296 hasAuthorship W2167789296A5087319030 @default.
• W2167789296 hasBestOaLocation W21677892961 @default.
• W2167789296 hasConcept C104317684 @default.
• W2167789296 hasConcept C159047783 @default.
• W2167789296 hasConcept C22744801 @default.
• W2167789296 hasConcept C2776650774 @default.
• W2167789296 hasConcept C2776968632 @default.
• W2167789296 hasConcept C2777058267 @default.

• next