FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2167806969> ?p ?o ?g. }

• W2167806969 endingPage "1071" @default.
• W2167806969 startingPage "1062" @default.
• W2167806969 abstract "T cell recognition of peptide/allogeneic MHC complexes is a major cause of transplant rejection. Both the presented self-peptides and the MHC molecules are involved; however, the molecular basis for alloreactivity and the contribution of self-peptides are still poorly defined. The murine 2.102 T cell is specific for hemoglobin(64-76)/I-Ek and is alloreactive to I-Ep. The natural self-peptide/I-Ep complex recognized by 2.102 remains unknown. In this study, we characterized the peptides that are naturally processed and presented by I-Ep and used this information to define the binding motif for the murine I-Ep class II molecule. Interestingly, we found that the P9 anchor residue preferred by I-Ep is quite distinct from the residues preferred by other I-E molecules, although the P1 anchor residue is conserved. A degree of specificity for the alloresponse was shown by the lack of stimulation of 2.102 T cells by 19 different identified self-peptides. The binding motif was used to search the mouse genome for candidate 2.102 reactive allopeptides that contain strong P1 and P9 anchor residues and possess previously identified allowable TCR contact residues. Two potential allopeptides were identified, but only one of these peptides, G protein-coupled receptor 128, was able to stimulate 2.102 T cells. Thus, the G protein-coupled receptor 128 peptide represents a candidate allopeptide that is specifically recognized by 2.102 T cells bound to I-Ep and was identified using bioinformatics. These studies highlight the specific involvement of self-peptides in alloreactivity." @default.
• W2167806969 created "2016-06-24" @default.
• W2167806969 creator A5014163270 @default.
• W2167806969 creator A5023806324 @default.
• W2167806969 creator A5031479644 @default.
• W2167806969 creator A5043414463 @default.
• W2167806969 creator A5044630363 @default.
• W2167806969 creator A5056445926 @default.
• W2167806969 date "2006-01-15" @default.
• W2167806969 modified "2023-10-04" @default.
• W2167806969 title "I-Ep-Bound Self-Peptides: Identification, Characterization, and Role in Alloreactivity" @default.
• W2167806969 cites W1487714785 @default.
• W2167806969 cites W1497871289 @default.
• W2167806969 cites W1552827176 @default.
• W2167806969 cites W1593152076 @default.
• W2167806969 cites W1607752827 @default.
• W2167806969 cites W1630218117 @default.
• W2167806969 cites W1879214463 @default.
• W2167806969 cites W1931483233 @default.
• W2167806969 cites W1931699789 @default.
• W2167806969 cites W1942862196 @default.
• W2167806969 cites W1964298483 @default.
• W2167806969 cites W1965986127 @default.
• W2167806969 cites W1973416709 @default.
• W2167806969 cites W1982389510 @default.
• W2167806969 cites W1982517532 @default.
• W2167806969 cites W1986216579 @default.
• W2167806969 cites W1991972957 @default.
• W2167806969 cites W1992196706 @default.
• W2167806969 cites W1994002287 @default.
• W2167806969 cites W1995317534 @default.
• W2167806969 cites W2000273475 @default.
• W2167806969 cites W2010936770 @default.
• W2167806969 cites W2015838695 @default.
• W2167806969 cites W2020347759 @default.
• W2167806969 cites W2024920946 @default.
• W2167806969 cites W2025476985 @default.
• W2167806969 cites W2032169064 @default.
• W2167806969 cites W2033893533 @default.
• W2167806969 cites W2034311985 @default.
• W2167806969 cites W2034712661 @default.
• W2167806969 cites W2034974584 @default.
• W2167806969 cites W2037184580 @default.
• W2167806969 cites W2041540782 @default.
• W2167806969 cites W2042591259 @default.
• W2167806969 cites W2043745393 @default.
• W2167806969 cites W2049076335 @default.
• W2167806969 cites W2051161478 @default.
• W2167806969 cites W2054157102 @default.
• W2167806969 cites W2055579456 @default.
• W2167806969 cites W2070145858 @default.
• W2167806969 cites W2071021373 @default.
• W2167806969 cites W2073115356 @default.
• W2167806969 cites W2077215890 @default.
• W2167806969 cites W2077372744 @default.
• W2167806969 cites W2079542677 @default.
• W2167806969 cites W2085831528 @default.
• W2167806969 cites W2087265337 @default.
• W2167806969 cites W2094970674 @default.
• W2167806969 cites W2103332118 @default.
• W2167806969 cites W2108861854 @default.
• W2167806969 cites W2117133038 @default.
• W2167806969 cites W2117746288 @default.
• W2167806969 cites W2124793991 @default.
• W2167806969 cites W2126134057 @default.
• W2167806969 cites W2133696052 @default.
• W2167806969 cites W2142428927 @default.
• W2167806969 cites W2143635337 @default.
• W2167806969 cites W2148382506 @default.
• W2167806969 cites W2150015291 @default.
• W2167806969 cites W2159586429 @default.
• W2167806969 cites W2161596564 @default.
• W2167806969 cites W2161725950 @default.
• W2167806969 cites W2161841913 @default.
• W2167806969 cites W2162679999 @default.
• W2167806969 cites W2163734114 @default.
• W2167806969 cites W2165227707 @default.
• W2167806969 cites W2166701484 @default.
• W2167806969 cites W2992138720 @default.
• W2167806969 cites W4322378225 @default.
• W2167806969 doi "https://doi.org/10.4049/jimmunol.176.2.1062" @default.
• W2167806969 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16393994" @default.
• W2167806969 hasPublicationYear "2006" @default.
• W2167806969 type Work @default.
• W2167806969 sameAs 2167806969 @default.
• W2167806969 citedByCount "14" @default.
• W2167806969 countsByYear W21678069692013 @default.
• W2167806969 countsByYear W21678069692016 @default.
• W2167806969 crossrefType "journal-article" @default.
• W2167806969 hasAuthorship W2167806969A5014163270 @default.
• W2167806969 hasAuthorship W2167806969A5023806324 @default.
• W2167806969 hasAuthorship W2167806969A5031479644 @default.
• W2167806969 hasAuthorship W2167806969A5043414463 @default.
• W2167806969 hasAuthorship W2167806969A5044630363 @default.
• W2167806969 hasAuthorship W2167806969A5056445926 @default.
• W2167806969 hasBestOaLocation W21678069691 @default.
• W2167806969 hasConcept C104317684 @default.
• W2167806969 hasConcept C153911025 @default.

• next