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- W2167814222 abstract "Dosage compensation equalizes X-linked gene products between the sexes. In Caenorhabditis elegans, the dosage compensation complex (DCC) binds both X chromosomes in XX animals and halves the transcription from each. The DCC is recruited to the X chromosomes by a number of loci, rex sites, and is thought to spread from these sites by an unknown mechanism to cover the rest of the chromosome. Here we describe a novel class of DCC-binding elements that we propose serve as way stations for DCC binding and spreading. Both rex sites and way stations comprise strong foci of DCC binding on the native X chromosome. However, rex sites maintain their ability to bind large amounts of DCC even on X duplications detached from the native X, while way stations do not. These results suggest that two distinct classes of DCC-binding elements facilitate recruitment and spreading of the DCC along the X chromosome." @default.
- W2167814222 created "2016-06-24" @default.
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- W2167814222 date "2009-04-01" @default.
- W2167814222 modified "2023-09-26" @default.
- W2167814222 title "Two Classes of Dosage Compensation Complex Binding Elements along <i>Caenorhabditis elegans</i> X Chromosomes" @default.
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- W2167814222 doi "https://doi.org/10.1128/mcb.01448-08" @default.
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