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• W2167815326 endingPage "431" @default.
• W2167815326 startingPage "415" @default.
• W2167815326 abstract "Coumarins represent a large group of 1,2-benzopyrone derivatives which have been identified in many natural sources and synthetized as well. Several studies have shown that their antioxidant capacity is not based only on direct scavenging of reactive oxygen and nitrogen species (RONS) but other mechanisms are also involved. These include: a) the chelation of transient metals iron and copper, which are known to catalyse the Fenton reaction; and b) the inhibition of RONS-producing enzymes (e.g. xanthine oxidase, myeloperoxidase and lipoxygenase), suggesting that mechanism(s) involved on cellular level are complex and synergistic. Moreover, many factors must be taken into account when analysing structure-antioxidant capacity relationships of coumarins due to different in vitro/in vivo methodological approaches. The structural features necessary for the direct RONS scavenging and metal chelation are apparently similar and the ideal structures are 6,7-dihydroxy- or 7,8-dihydroxycoumarins. However, the clinical outcome is unknown, because these coumarins are able to reduce copper and iron, and may thus paradoxically potentiate the Fenton chemistry. The similar structural features appear to be associated with inhibition of lipoxygenase, probably due to interference with iron in its active site. Contrarily, 6,7-dihydroxycoumarin seems to be the most active coumarin in the inhibition of xanthine oxidase while its derivative bearing the 4-methyl group or 7,8-dihydroxycoumarin are less active or inactive. In addition, coumarins may hinder the induction of inducible NO-synthase and cyclooxygenase- 2. Sparse data on inhibition of myeloperoxidase do not enable any clear conclusion, but some coumarins may block it. Keywords: Antioxidant, Copper, Coumarins, Iron, Lipoxygenase, Myeloperoxidase, Xanthine oxidase." @default.
• W2167815326 created "2016-06-24" @default.
• W2167815326 creator A5020959791 @default.
• W2167815326 creator A5022352437 @default.
• W2167815326 creator A5029120071 @default.
• W2167815326 creator A5060304564 @default.
• W2167815326 creator A5071346689 @default.
• W2167815326 creator A5075845989 @default.
• W2167815326 date "2015-02-23" @default.
• W2167815326 modified "2023-10-05" @default.
• W2167815326 title "Antioxidant Effects of Coumarins Include Direct Radical Scavenging, Metal Chelation and Inhibition of ROS-Producing Enzymes" @default.
• W2167815326 cites W1034850990 @default.
• W2167815326 cites W1516903579 @default.
• W2167815326 cites W1564455412 @default.
• W2167815326 cites W1574544450 @default.
• W2167815326 cites W1588449570 @default.
• W2167815326 cites W161135547 @default.
• W2167815326 cites W1680799029 @default.
• W2167815326 cites W1719110224 @default.
• W2167815326 cites W1748602285 @default.
• W2167815326 cites W1953423403 @default.
• W2167815326 cites W1960378678 @default.
• W2167815326 cites W1968998478 @default.
• W2167815326 cites W1969816194 @default.
• W2167815326 cites W1970431536 @default.
• W2167815326 cites W1970617706 @default.
• W2167815326 cites W1971354083 @default.
• W2167815326 cites W1972248486 @default.
• W2167815326 cites W1973094184 @default.
• W2167815326 cites W1974330196 @default.
• W2167815326 cites W1975384542 @default.
• W2167815326 cites W1975641686 @default.
• W2167815326 cites W1975794278 @default.
• W2167815326 cites W1977232394 @default.
• W2167815326 cites W1980302162 @default.
• W2167815326 cites W1981827688 @default.
• W2167815326 cites W1983078355 @default.
• W2167815326 cites W1986765526 @default.
• W2167815326 cites W1988872182 @default.
• W2167815326 cites W1991763008 @default.
• W2167815326 cites W1995917438 @default.
• W2167815326 cites W1997878336 @default.
• W2167815326 cites W1998424487 @default.
• W2167815326 cites W1998910288 @default.
• W2167815326 cites W1999270548 @default.
• W2167815326 cites W2000103162 @default.
• W2167815326 cites W2000914251 @default.
• W2167815326 cites W2002410344 @default.
• W2167815326 cites W2002709823 @default.
• W2167815326 cites W2004771515 @default.
• W2167815326 cites W2004847016 @default.
• W2167815326 cites W2006277899 @default.
• W2167815326 cites W2007054543 @default.
• W2167815326 cites W2007790651 @default.
• W2167815326 cites W2009862659 @default.
• W2167815326 cites W2009985752 @default.
• W2167815326 cites W2010001792 @default.
• W2167815326 cites W2011360233 @default.
• W2167815326 cites W2011469832 @default.
• W2167815326 cites W2011680286 @default.
• W2167815326 cites W2014509727 @default.
• W2167815326 cites W2014895648 @default.
• W2167815326 cites W2015862304 @default.
• W2167815326 cites W2016185230 @default.
• W2167815326 cites W2017039268 @default.
• W2167815326 cites W2017473714 @default.
• W2167815326 cites W2018427834 @default.
• W2167815326 cites W2019391261 @default.
• W2167815326 cites W2022657929 @default.
• W2167815326 cites W2027757388 @default.
• W2167815326 cites W2029533353 @default.
• W2167815326 cites W2030305241 @default.
• W2167815326 cites W2030872956 @default.
• W2167815326 cites W2036225919 @default.
• W2167815326 cites W2038698953 @default.
• W2167815326 cites W2040533272 @default.
• W2167815326 cites W2041294115 @default.
• W2167815326 cites W2041855502 @default.
• W2167815326 cites W2043025607 @default.
• W2167815326 cites W2044889191 @default.
• W2167815326 cites W2045476180 @default.
• W2167815326 cites W2048645395 @default.
• W2167815326 cites W2049744472 @default.
• W2167815326 cites W2050036109 @default.
• W2167815326 cites W2050175611 @default.
• W2167815326 cites W2052244043 @default.
• W2167815326 cites W2056580245 @default.
• W2167815326 cites W2059520629 @default.
• W2167815326 cites W2059693823 @default.
• W2167815326 cites W2061028727 @default.
• W2167815326 cites W2063802100 @default.
• W2167815326 cites W2065126402 @default.
• W2167815326 cites W2065465124 @default.
• W2167815326 cites W2066712063 @default.
• W2167815326 cites W2069267604 @default.
• W2167815326 cites W2070228974 @default.
• W2167815326 cites W2070468504 @default.
• W2167815326 cites W2073041528 @default.

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