FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2167826437> ?p ?o ?g. }

• W2167826437 endingPage "695" @default.
• W2167826437 startingPage "681" @default.
• W2167826437 abstract "Abstract Microtubules in yeast are functional components of the mitotic and meiotic spindles and are essential for nuclear movement during cell division and mating. We have isolated 70 conditional-lethal mutations in the TUB1 alpha-tubulin gene of the yeast Saccharomyces cerevisiae using a plasmid replacement technique. Of the 70 mutations isolated, 67 resulted in cold-sensitivity, one resulted in temperature-sensitivity, and two resulted in both. Fine-structure mapping revealed that the mutations were located throughout the TUB1 gene. We characterized the phenotypes caused by 38 of the mutations after shifts of mutants to the nonpermissive temperature. Populations of temperature-shifted mutant cells contained an excess of large-budded cells with undivided nuclei, consistent with the previously determined role of microtubules in yeast mitosis. Several of the mutants arrested growth with a sufficiently uniform morphology to indicate that TUB1 has at least one specific role in the progression of the yeast cell cycle. A number of the mutants had gross defects in microtubule assembly at the restrictive temperature, some with no microtubules and some with excess microtubules. Other mutants contained disorganized microtubules and nuclei. There were no obvious correlations between these phenotypes and the map positions of the mutations. Greater than 90% of the mutants examined were hypersensitive to the antimicrotubule drug benomyl. Mutations that suppressed the cold-sensitive phenotypes of two of the TUB1 alleles occurred in TUB2, the single structural gene specifying beta-tubulin." @default.
• W2167826437 created "2016-06-24" @default.
• W2167826437 creator A5049485062 @default.
• W2167826437 creator A5077542898 @default.
• W2167826437 creator A5080637068 @default.
• W2167826437 date "1988-11-01" @default.
• W2167826437 modified "2023-10-16" @default.
• W2167826437 title "Isolation and characterization of conditional-lethal mutations in the TUB1 alpha-tubulin gene of the yeast Saccharomyces cerevisiae." @default.
• W2167826437 cites W1433017100 @default.
• W2167826437 cites W1559808711 @default.
• W2167826437 cites W1590517386 @default.
• W2167826437 cites W1749612483 @default.
• W2167826437 cites W1804602231 @default.
• W2167826437 cites W1812341569 @default.
• W2167826437 cites W1856508030 @default.
• W2167826437 cites W1867104563 @default.
• W2167826437 cites W1895018249 @default.
• W2167826437 cites W1920405460 @default.
• W2167826437 cites W1931470717 @default.
• W2167826437 cites W1969737313 @default.
• W2167826437 cites W1981919833 @default.
• W2167826437 cites W1985910275 @default.
• W2167826437 cites W1992332411 @default.
• W2167826437 cites W1996380608 @default.
• W2167826437 cites W1999917330 @default.
• W2167826437 cites W2003949273 @default.
• W2167826437 cites W2008517878 @default.
• W2167826437 cites W2011498074 @default.
• W2167826437 cites W2014606069 @default.
• W2167826437 cites W2018215453 @default.
• W2167826437 cites W2027487910 @default.
• W2167826437 cites W2028569284 @default.
• W2167826437 cites W2030837975 @default.
• W2167826437 cites W2032668403 @default.
• W2167826437 cites W2042464607 @default.
• W2167826437 cites W2043517704 @default.
• W2167826437 cites W2047049388 @default.
• W2167826437 cites W2047344741 @default.
• W2167826437 cites W2051696655 @default.
• W2167826437 cites W2060397969 @default.
• W2167826437 cites W2064825877 @default.
• W2167826437 cites W2065359944 @default.
• W2167826437 cites W2080918762 @default.
• W2167826437 cites W2083242648 @default.
• W2167826437 cites W2109573032 @default.
• W2167826437 cites W2109829281 @default.
• W2167826437 cites W2117047559 @default.
• W2167826437 cites W2132611765 @default.
• W2167826437 cites W2133128874 @default.
• W2167826437 cites W2148881591 @default.
• W2167826437 cites W2150701678 @default.
• W2167826437 cites W2152125010 @default.
• W2167826437 cites W2412776759 @default.
• W2167826437 doi "https://doi.org/10.1093/genetics/120.3.681" @default.
• W2167826437 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1203547" @default.
• W2167826437 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3066684" @default.
• W2167826437 hasPublicationYear "1988" @default.
• W2167826437 type Work @default.
• W2167826437 sameAs 2167826437 @default.
• W2167826437 citedByCount "106" @default.
• W2167826437 countsByYear W21678264372012 @default.
• W2167826437 countsByYear W21678264372013 @default.
• W2167826437 countsByYear W21678264372014 @default.
• W2167826437 countsByYear W21678264372015 @default.
• W2167826437 countsByYear W21678264372016 @default.
• W2167826437 countsByYear W21678264372017 @default.
• W2167826437 countsByYear W21678264372018 @default.
• W2167826437 countsByYear W21678264372019 @default.
• W2167826437 countsByYear W21678264372020 @default.
• W2167826437 countsByYear W21678264372022 @default.
• W2167826437 crossrefType "journal-article" @default.
• W2167826437 hasAuthorship W2167826437A5049485062 @default.
• W2167826437 hasAuthorship W2167826437A5077542898 @default.
• W2167826437 hasAuthorship W2167826437A5080637068 @default.
• W2167826437 hasBestOaLocation W21678264371 @default.
• W2167826437 hasConcept C104317684 @default.
• W2167826437 hasConcept C143065580 @default.
• W2167826437 hasConcept C1491633281 @default.
• W2167826437 hasConcept C153911025 @default.
• W2167826437 hasConcept C20418707 @default.
• W2167826437 hasConcept C2777576037 @default.
• W2167826437 hasConcept C2779222958 @default.
• W2167826437 hasConcept C501734568 @default.
• W2167826437 hasConcept C54355233 @default.
• W2167826437 hasConcept C84425145 @default.
• W2167826437 hasConcept C85813293 @default.
• W2167826437 hasConcept C86803240 @default.
• W2167826437 hasConcept C93304396 @default.
• W2167826437 hasConcept C95444343 @default.
• W2167826437 hasConceptScore W2167826437C104317684 @default.
• W2167826437 hasConceptScore W2167826437C143065580 @default.
• W2167826437 hasConceptScore W2167826437C1491633281 @default.
• W2167826437 hasConceptScore W2167826437C153911025 @default.
• W2167826437 hasConceptScore W2167826437C20418707 @default.
• W2167826437 hasConceptScore W2167826437C2777576037 @default.
• W2167826437 hasConceptScore W2167826437C2779222958 @default.
• W2167826437 hasConceptScore W2167826437C501734568 @default.
• W2167826437 hasConceptScore W2167826437C54355233 @default.

• next