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• W2167828103 abstract "<h3>Background</h3> Venous leg ulceration is a frequent and severe complication of lower limb venous insufficiency. Compression therapy is associated with a protracted course of healing and multiple recurrences. Minimally invasive surgery (subfascial endoscopic perforating surgery) is only possible in a subset of patients with leg ulcers. Low-cost and noninvasive therapeutic procedures are needed as alternative treatments. <h3>Objective</h3> To evaluate the efficacy and safety of sclerosant in microfoam in treating venous leg ulceration. <h3>Design</h3> A retrospective study of medical records, pretreatment and posttreatment color photographs, and echo Doppler in patients with venous leg ulceration. All patients were evaluated at 6 months after therapy, 70% were also evaluated at 2 years, 25% at 3 years, and 14% at 4 or more years after treatment. They were assessed for complete (100%) ulcer healing, time to wound closure, and recurrence. <h3>Setting</h3> Private vascular surgery clinic in Granada and dermatology department at a hospital in Pamplona, Spain. <h3>Patients</h3> Over 115 months, 116 consecutive patients (mean age [range], 57 [25-85] years) treated with ultrasound-guided injection of polidocanol microfoam (UIPM). <h3>Interventions</h3> To reduce venous hypertension, UIPM was used to selectively and progressively sclerose sources of incompetence. The number of sessions per patient varied between 1 and 17 (mean, 3.6). <h3>Main Outcome Measures</h3> Complete ulcer healing, defined as full reepithelialization of the wound with absence of drainage. Recurrence was defined as epithelial breakdown in the healed limb. <h3>Results</h3> At 6-months' follow-up, treatment with UIPM achieved complete healing in 83% of patients (96/116), with median time to healing of 2.7 months; 7 patients were never cured, and 1 patient was lost to follow-up. There were recurrences in 10 patients. <h3>Conclusions</h3> The use of UIPM to selectively and progressively sclerose incompetent veins produced by venous hypertension is highly effective to achieve a stable ulcer healing with minimal invasion, even in elderly patients. Recurrences are easily treatable with this approach. This technique may become a first-line treatment in the management of leg venous ulcers." @default.
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• W2167828103 date "2004-06-01" @default.
• W2167828103 modified "2023-10-18" @default.
• W2167828103 title "Ultrasound-Guided Injection of Polidocanol Microfoam in the Management of Venous Leg Ulcers" @default.
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• W2167828103 doi "https://doi.org/10.1001/archderm.140.6.667" @default.
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