FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2167831284> ?p ?o ?g. }

• W2167831284 endingPage "100" @default.
• W2167831284 startingPage "89" @default.
• W2167831284 abstract "During variable/diversity/joining (V[D]J) recombination, the enzyme terminal deoxynucleotidyl transferase (Tdt) adds random nucleotides at the junctions of the rearranging gene segments, increasing diversity of the antibody (Ab) and T cell receptor repertoires. Two splice variants of Tdt have been described, but only one (short isoform of Tdt [TdtS]) has been convincingly demonstrated to catalyze nontemplated (N) addition in vitro. We have expressed each splice variant of Tdt in transgenic (Tg) mice and found that the TdtS transgene catalyzes N addition on the endogenous Tdt−/− background and in fetal liver, but that the long isoform of Tdt (TdtL) transgene does neither. In contrast to previous in vitro results, both TdtS and TdtL are translocated to the nucleus in our model. Furthermore, TdtL/TdtS double Tg mice exhibit less N addition in fetal liver than do TdtS Tg mice. Whereas the TdtS transgene was shown to have functional consequences on the antiphosphorylcholine (PC) B cell repertoire, TdtL Tg mice exhibit a normal PC response, and Tdt−/− mice actually exhibit an increase in the PC response and in TEPC 15 idiotype+ Ab production. We conclude that TdtL localizes to the nucleus in vivo where it serves to modulate TdtS function." @default.
• W2167831284 created "2016-06-24" @default.
• W2167831284 creator A5015718586 @default.
• W2167831284 creator A5021331386 @default.
• W2167831284 creator A5060437129 @default.
• W2167831284 date "2001-01-01" @default.
• W2167831284 modified "2023-09-26" @default.
• W2167831284 title "The Long Isoform of Terminal Deoxynucleotidyl Transferase Enters the Nucleus And, Rather than Catalyzing Nontemplated Nucleotide Addition, Modulates the Catalytic Activity of the Short Isoform" @default.
• W2167831284 cites W1488045575 @default.
• W2167831284 cites W1552177814 @default.
• W2167831284 cites W1579068026 @default.
• W2167831284 cites W1593785927 @default.
• W2167831284 cites W1637561808 @default.
• W2167831284 cites W1678050402 @default.
• W2167831284 cites W1883290480 @default.
• W2167831284 cites W1894411589 @default.
• W2167831284 cites W1935936757 @default.
• W2167831284 cites W1966866685 @default.
• W2167831284 cites W1975445093 @default.
• W2167831284 cites W1979034618 @default.
• W2167831284 cites W1982645904 @default.
• W2167831284 cites W1991756452 @default.
• W2167831284 cites W1995233249 @default.
• W2167831284 cites W1997056099 @default.
• W2167831284 cites W2002027552 @default.
• W2167831284 cites W2005028500 @default.
• W2167831284 cites W2010776654 @default.
• W2167831284 cites W2038721294 @default.
• W2167831284 cites W2042877551 @default.
• W2167831284 cites W2054430911 @default.
• W2167831284 cites W2058702179 @default.
• W2167831284 cites W2065400558 @default.
• W2167831284 cites W2070116447 @default.
• W2167831284 cites W2072415380 @default.
• W2167831284 cites W2075207584 @default.
• W2167831284 cites W2077449764 @default.
• W2167831284 cites W2084492613 @default.
• W2167831284 cites W2086771595 @default.
• W2167831284 cites W2089155355 @default.
• W2167831284 cites W2094071228 @default.
• W2167831284 cites W2103516617 @default.
• W2167831284 cites W2106960031 @default.
• W2167831284 cites W2107483516 @default.
• W2167831284 cites W2115487618 @default.
• W2167831284 cites W2130658643 @default.
• W2167831284 cites W2131847878 @default.
• W2167831284 cites W2151042873 @default.
• W2167831284 cites W2151892297 @default.
• W2167831284 cites W2164662693 @default.
• W2167831284 cites W2169128640 @default.
• W2167831284 cites W54886159 @default.
• W2167831284 doi "https://doi.org/10.1084/jem.193.1.89" @default.
• W2167831284 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2195880" @default.
• W2167831284 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11136823" @default.
• W2167831284 hasPublicationYear "2001" @default.
• W2167831284 type Work @default.
• W2167831284 sameAs 2167831284 @default.
• W2167831284 citedByCount "22" @default.
• W2167831284 countsByYear W21678312842012 @default.
• W2167831284 countsByYear W21678312842014 @default.
• W2167831284 countsByYear W21678312842017 @default.
• W2167831284 countsByYear W21678312842018 @default.
• W2167831284 countsByYear W21678312842020 @default.
• W2167831284 crossrefType "journal-article" @default.
• W2167831284 hasAuthorship W2167831284A5015718586 @default.
• W2167831284 hasAuthorship W2167831284A5021331386 @default.
• W2167831284 hasAuthorship W2167831284A5060437129 @default.
• W2167831284 hasBestOaLocation W21678312841 @default.
• W2167831284 hasConcept C102230213 @default.
• W2167831284 hasConcept C104317684 @default.
• W2167831284 hasConcept C141035611 @default.
• W2167831284 hasConcept C153911025 @default.
• W2167831284 hasConcept C154113507 @default.
• W2167831284 hasConcept C190283241 @default.
• W2167831284 hasConcept C194583182 @default.
• W2167831284 hasConcept C196795494 @default.
• W2167831284 hasConcept C53345823 @default.
• W2167831284 hasConcept C55493867 @default.
• W2167831284 hasConcept C86803240 @default.
• W2167831284 hasConceptScore W2167831284C102230213 @default.
• W2167831284 hasConceptScore W2167831284C104317684 @default.
• W2167831284 hasConceptScore W2167831284C141035611 @default.
• W2167831284 hasConceptScore W2167831284C153911025 @default.
• W2167831284 hasConceptScore W2167831284C154113507 @default.
• W2167831284 hasConceptScore W2167831284C190283241 @default.
• W2167831284 hasConceptScore W2167831284C194583182 @default.
• W2167831284 hasConceptScore W2167831284C196795494 @default.
• W2167831284 hasConceptScore W2167831284C53345823 @default.
• W2167831284 hasConceptScore W2167831284C55493867 @default.
• W2167831284 hasConceptScore W2167831284C86803240 @default.
• W2167831284 hasIssue "1" @default.
• W2167831284 hasLocation W21678312841 @default.
• W2167831284 hasLocation W21678312842 @default.
• W2167831284 hasLocation W21678312843 @default.
• W2167831284 hasLocation W21678312844 @default.
• W2167831284 hasOpenAccess W2167831284 @default.
• W2167831284 hasPrimaryLocation W21678312841 @default.
• W2167831284 hasRelatedWork W1992245252 @default.

• next