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- W2167852072 abstract "Myocardial depressant actions of seven antiarrhythmic drugs have been studied in vitro in guinea-pig papillary muscle preparations, using upstroke velocity of action potentials as a measure of myocardial excitability. Drug-induced depression of upstroke velocity is shown to be greater after an action potential than before; upstroke velocity recovers from such use-induced depression with widely varying half-times ranging from a tenth of a second to several seconds, depending upon the drug. Lipophilic drug structures having small molecular weights (below 250) all appear to display the short half-times required to give these drugs unique capabilities to block selectively extrasystoles and other high frequency arrhythmias in myocardium. Larger drug structures, or those having very low lipid solubility such as procainamide, will block excitability in a much less frequency-dependent or interval-dependent manner." @default.
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- W2167852072 date "1980-11-01" @default.
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- W2167852072 title "Interval-dependent effects of small antiarrhythmic drugs on excitability of guinea-pig myocardium" @default.
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- W2167852072 doi "https://doi.org/10.1016/0022-2828(80)90071-1" @default.
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