FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2167871024> ?p ?o ?g. }

• W2167871024 endingPage "55" @default.
• W2167871024 startingPage "48" @default.
• W2167871024 abstract "Hemolytic-uremic syndrome (HUS), mainly caused by Shiga toxin (Stx) producingEscherichia coli (STEC) such as E. coli O157:H7 and STEC/EAggEC, is a serious complication predominantly leading to renal failure and even death. We have previously reported that a monoclonal antibody effectively neutralizes Stx2 in vitro and in vivo toxicity models. As a therapeutic agent against HUS, the mouse origin of this antibody can trigger human anti-murine antibody (HAMA) reactions thereby restricting its clinical application. In order to reduce its immunogenicity for use in humans, in this study, a mouse/human chimeric antibody designated rS2C4-IgG1 was developed in baculovirus/insect cell expression system. Analysis of antigen-binding and competitive binding revealed that rS2C4-IgG1 possessed specificity and affinity similar to that of S2C4. Results from cytotoxicity assays and mouse toxicity model analysis showed that rS2C4-IgG1offers neutralizing activity comparable to its parent MAb in vitro and in vivo. Therefore, the chimeric rS2C4-IgG1 had great potential for use in the treatment of STEC infection.   Key words: Shiga toxin 2, HUS, STEC, chimeric rS2C4-IgG1." @default.
• W2167871024 created "2016-06-24" @default.
• W2167871024 creator A5010087069 @default.
• W2167871024 creator A5015173885 @default.
• W2167871024 creator A5032969232 @default.
• W2167871024 creator A5040031405 @default.
• W2167871024 creator A5046212412 @default.
• W2167871024 creator A5052883436 @default.
• W2167871024 creator A5060239112 @default.
• W2167871024 creator A5060962650 @default.
• W2167871024 creator A5063004211 @default.
• W2167871024 creator A5063496433 @default.
• W2167871024 creator A5080625732 @default.
• W2167871024 creator A5083464792 @default.
• W2167871024 date "2013-01-01" @default.
• W2167871024 modified "2023-10-02" @default.
• W2167871024 title "Engineering and evaluation of a mouse/human chimeric antibody against Shiga toxin 2" @default.
• W2167871024 cites W1939186328 @default.
• W2167871024 cites W1975033484 @default.
• W2167871024 cites W1980264144 @default.
• W2167871024 cites W1982201679 @default.
• W2167871024 cites W1983494459 @default.
• W2167871024 cites W1985837387 @default.
• W2167871024 cites W2005814055 @default.
• W2167871024 cites W2016759586 @default.
• W2167871024 cites W2023985105 @default.
• W2167871024 cites W2025984517 @default.
• W2167871024 cites W2026212866 @default.
• W2167871024 cites W2065419141 @default.
• W2167871024 cites W2066018712 @default.
• W2167871024 cites W2075097399 @default.
• W2167871024 cites W2079187574 @default.
• W2167871024 cites W2099906854 @default.
• W2167871024 cites W2122709869 @default.
• W2167871024 cites W2131668815 @default.
• W2167871024 cites W2133912554 @default.
• W2167871024 cites W2154924523 @default.
• W2167871024 cites W2156327171 @default.
• W2167871024 cites W2171333039 @default.
• W2167871024 cites W2322879478 @default.
• W2167871024 cites W2329907843 @default.
• W2167871024 cites W2371943944 @default.
• W2167871024 cites W41147460 @default.
• W2167871024 doi "https://doi.org/10.5897/ajmr12.1583" @default.
• W2167871024 hasPublicationYear "2013" @default.
• W2167871024 type Work @default.
• W2167871024 sameAs 2167871024 @default.
• W2167871024 citedByCount "0" @default.
• W2167871024 crossrefType "journal-article" @default.
• W2167871024 hasAuthorship W2167871024A5010087069 @default.
• W2167871024 hasAuthorship W2167871024A5015173885 @default.
• W2167871024 hasAuthorship W2167871024A5032969232 @default.
• W2167871024 hasAuthorship W2167871024A5040031405 @default.
• W2167871024 hasAuthorship W2167871024A5046212412 @default.
• W2167871024 hasAuthorship W2167871024A5052883436 @default.
• W2167871024 hasAuthorship W2167871024A5060239112 @default.
• W2167871024 hasAuthorship W2167871024A5060962650 @default.
• W2167871024 hasAuthorship W2167871024A5063004211 @default.
• W2167871024 hasAuthorship W2167871024A5063496433 @default.
• W2167871024 hasAuthorship W2167871024A5080625732 @default.
• W2167871024 hasAuthorship W2167871024A5083464792 @default.
• W2167871024 hasBestOaLocation W21678710241 @default.
• W2167871024 hasConcept C104317684 @default.
• W2167871024 hasConcept C109316439 @default.
• W2167871024 hasConcept C147483822 @default.
• W2167871024 hasConcept C150903083 @default.
• W2167871024 hasConcept C159047783 @default.
• W2167871024 hasConcept C159654299 @default.
• W2167871024 hasConcept C185592680 @default.
• W2167871024 hasConcept C202751555 @default.
• W2167871024 hasConcept C203014093 @default.
• W2167871024 hasConcept C207001950 @default.
• W2167871024 hasConcept C2778411228 @default.
• W2167871024 hasConcept C2780868878 @default.
• W2167871024 hasConcept C542903549 @default.
• W2167871024 hasConcept C547475151 @default.
• W2167871024 hasConcept C55493867 @default.
• W2167871024 hasConcept C86803240 @default.
• W2167871024 hasConcept C89423630 @default.
• W2167871024 hasConceptScore W2167871024C104317684 @default.
• W2167871024 hasConceptScore W2167871024C109316439 @default.
• W2167871024 hasConceptScore W2167871024C147483822 @default.
• W2167871024 hasConceptScore W2167871024C150903083 @default.
• W2167871024 hasConceptScore W2167871024C159047783 @default.
• W2167871024 hasConceptScore W2167871024C159654299 @default.
• W2167871024 hasConceptScore W2167871024C185592680 @default.
• W2167871024 hasConceptScore W2167871024C202751555 @default.
• W2167871024 hasConceptScore W2167871024C203014093 @default.
• W2167871024 hasConceptScore W2167871024C207001950 @default.
• W2167871024 hasConceptScore W2167871024C2778411228 @default.
• W2167871024 hasConceptScore W2167871024C2780868878 @default.
• W2167871024 hasConceptScore W2167871024C542903549 @default.
• W2167871024 hasConceptScore W2167871024C547475151 @default.
• W2167871024 hasConceptScore W2167871024C55493867 @default.
• W2167871024 hasConceptScore W2167871024C86803240 @default.
• W2167871024 hasConceptScore W2167871024C89423630 @default.
• W2167871024 hasIssue "1" @default.
• W2167871024 hasLocation W21678710241 @default.

• next