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• W2167875547 abstract "Mercury toxicosis has been reported in cats, pigs, calves, horses, and laboratory animals (rats, mice, mink, ferrets, and guinea pigs) but rarely in dogs. Clinical signs and lesions of mercury intoxication depend on the species affected, dose obtained, route of administration, chronicity of exposure, and the chemical form of the mercury involved. 12,28.29,32-34 The few reports of mercury toxicity in dogs discuss renal but not neurologic abnormalities. A 6-year-old obese (9.13 kg) ovariohysterectomized Shih Tzu was referred to the Texas Veterinary Medical Center (TVMC) for evaluation of progressive neurologic and gastrointestinal signs of 3 days’ duration. The dog was initially presented to the referring veterinarian for a 1-day history of intermittent vomiting of blood-tinged mucus. On presentation to the referring veterinarian, the dog had a painful abdomen, vomited blood-tinged, foamy mucus twice during examination, and developed watery, bloody diarrhea. The dog was hospitalized and intravenous fluid, anti-inflammatory (prednisolone sodium phosphate, flumethasone), and antibiotic (ampicillin) therapies were instituted. While hospitalized, the dog developed mild horizontal nystagmus, a right head tilt, ataxia, and reluctance to walk, which progressed over 3 hours to severe horizontal nystagmus, tetraparesis, extensor rigidity in all limbs, and opisthotonos unresponsive to diazepam therapy. Upon referral to TVMC the following day, the dog was recumbent and depressed. Physical examination revealed bilaterally absent pupillary light reflexes and horizontal nystagmus, weak withdrawal reflexes in all limbs, opisthotonos, and tetraparesis. The dog continued to exhibit a painful abdomen and bloody diarrhea. A hemogram and serum biochemistry profile revealed lymphocytopenia (77 cells/μl; reference range, 1,000-4,800 cells/μl hypokalemia (3.0 meq/liter; reference range, 3.55.0 meq/liter), and hypocalcemia (8.8 mg/dl; reference range, 9.3-11.8 mg/dl). Cervical cistemal cerebrospinal fluid aspiration contained peripheral blood contamination (15,000 erythrocytes/& increased protein (571.4 mg/dl), and pleocytosis (134 leukocytes/μl) consisting of monocytes with occasional lymphocytes, degenerative neutrophils, and rare nucleated erythrocytes. Electroencephalogram, abdominal radiographs, urinalysis, fecal flotation and smears, parvovirus enzyme-linked immunosorbent assay, and clotting profiles were normal. The dog continued to have abdominal pain, bloody diarrhea, and vomiting despite intravenous fluids, dimethylsulfoxide, and chloramphenicol therapy. Bilateral vertical nystagmus developed, and 4 episodes of seizures lasting 1-20" @default.
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• W2167875547 date "1994-10-01" @default.
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• W2167875547 title "Pathology in a Dog Associated with Elevated Tissue Mercury Concentrations" @default.
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• W2167875547 doi "https://doi.org/10.1177/104063879400600426" @default.
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