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• W2167882777 abstract "Time-Controlled Explosion System (TES) has the time-controlled drug release property with a predesigned lag time. The drug release from the system is initiated by destruction of the membrane. In this study, metoprolol tartrate was used as a model drug. After five types of TES with different in vitro lag times were orally administrated to dogs, plasma metoprolol concentration was monitored. There existed a good correlation between in vitro and in vivo lag time, while the extent of absorbed metoprolol decreased with prolongation of lag time. Next, the in vivo drug release behavior was directly investigated using five different colored TES with a lag time of two hours. Each TES was consecutively administrated to the fasted dogs at predetermined intervals. The amount of metoprolol released was monitored by recovering the administered TES from the gastrointestinal trace. The in vivo release profile corrresponded with the in vitro one. It is demonstrated that TES can release the drug in in vivo conditions similarly to in vitro. Based on these results, the decrease of the absorption is suggested to be caused by increased hepatic first-pass metabolism of the drug due to the retarded release rate with longer lag time." @default.
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• W2167882777 date "1994-01-01" @default.
• W2167882777 modified "2023-09-25" @default.
• W2167882777 title "Development of a Novel Drug Delivery System, Time-Controlled Explosion System (TES). IV.<i>In Vivo</i>Drug Release Behavior" @default.
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• W2167882777 doi "https://doi.org/10.3109/10611869409015901" @default.
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