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- W2167899487 abstract "Monoclonal antibodies (MAbs) specific for O polysaccharide or core oligosaccharide/lipid A of Escherichia coli O111:B4 lipopolysaccharide (LPS) were compared in canine septic shock. Animals received O-specific, core-specific, or control murine IgG2a MAbs (or saline) before intraperitoneal implantation of an E. coli O111:B4-infected clot. Animals were further randomized to ceftriaxone or saline. O-specific MAb significantly reduced bacteremia and endotoxemia but not serum tumor necrosis factor. Core-specific MAb significantly increased mean arterial pressure from day 4 to 28 (P = .02). In dogs not receiving ceftriaxone, survival was enhanced by O-specific MAb (4/5) compared with core-specific MAb (0/5) and control (1/8) (P = .03). Survival rates were similar (P = .22) but survival was prolonged in antibiotic-treated animals also receiving O-specific MAb (P = .02 vs. core-specific MAb and controls) or core-specific MAb (P = .08 vs. controls). These data support the complex role of LPS in sepsis and the discrete functional effects of MAbs specific for different elements of LPS." @default.
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- W2167899487 date "1994-03-01" @default.
- W2167899487 modified "2023-10-16" @default.
- W2167899487 title "Distinct Functional Activities in Canine Septic Shock of Monoclonal Antibodies Specific for the O Polysaccharide and Core Regions of Escherichia coli Lipopolysaccharide" @default.
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- W2167899487 doi "https://doi.org/10.1093/infdis/169.3.553" @default.
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