Matches in SemOpenAlex for { <https://semopenalex.org/work/W2167905519> ?p ?o ?g. }
- W2167905519 endingPage "829" @default.
- W2167905519 startingPage "829" @default.
- W2167905519 abstract "Schizophrenia is frequently accompanied by hypometabolism and altered gene expression in the prefrontal cortex. Cellular metabolism regulates chromatin structure, including covalent histone modifications, which are epigenetic regulators of gene expression.To test the hypothesis that down-regulated metabolic gene expression is associated with histone modification changes in the prefrontal cortex of subjects with schizophrenia.Histones and gene transcripts were profiled in the postmortem prefrontal cortex of 41 subjects with schizophrenia and 41 matched controls. The phosphorylation, acetylation, and methylation of 6 lysine, serine, and arginine residues of histones H3 and H4 were examined together with 16 metabolic gene transcripts using serial immunoblotting, immunohistochemical analysis, custom-made complementary DNA arrays, and quantitative real-time reverse transcriptase-polymerase chain reaction.Subjects with schizophrenia, as a group, showed no significant alterations in histone profiles or gene expression. In a subgroup of 8 patients with schizophrenia, levels of H3-(methyl)arginine 17, H3meR17, exceeded control values by 30%, and this was associated with the decreased expression of 4 metabolic transcripts.High levels of H3-(methyl)arginine 17 are associated with down-regulated metabolic gene expression in the prefrontal cortex of a subset of subjects with schizophrenia. Histone modifications may contribute to the pathogenesis of prefrontal dysfunction in schizophrenia." @default.
- W2167905519 created "2016-06-24" @default.
- W2167905519 creator A5001439788 @default.
- W2167905519 creator A5004088816 @default.
- W2167905519 creator A5023252875 @default.
- W2167905519 creator A5025600687 @default.
- W2167905519 creator A5029609183 @default.
- W2167905519 creator A5035967420 @default.
- W2167905519 creator A5036771773 @default.
- W2167905519 creator A5044023752 @default.
- W2167905519 creator A5053140200 @default.
- W2167905519 creator A5054827230 @default.
- W2167905519 creator A5058733663 @default.
- W2167905519 creator A5059811201 @default.
- W2167905519 date "2005-08-01" @default.
- W2167905519 modified "2023-09-26" @default.
- W2167905519 title "Chromatin Alterations Associated With Down-regulated Metabolic Gene Expression in the Prefrontal Cortex of Subjects With Schizophrenia" @default.
- W2167905519 cites W1509658065 @default.
- W2167905519 cites W1574682683 @default.
- W2167905519 cites W1732798991 @default.
- W2167905519 cites W1966279131 @default.
- W2167905519 cites W1969691479 @default.
- W2167905519 cites W1971334707 @default.
- W2167905519 cites W1974262619 @default.
- W2167905519 cites W1975900900 @default.
- W2167905519 cites W1977931536 @default.
- W2167905519 cites W1978380013 @default.
- W2167905519 cites W1978974174 @default.
- W2167905519 cites W1982044218 @default.
- W2167905519 cites W1987431889 @default.
- W2167905519 cites W1988486070 @default.
- W2167905519 cites W1988802552 @default.
- W2167905519 cites W1991965466 @default.
- W2167905519 cites W1992073044 @default.
- W2167905519 cites W1992876329 @default.
- W2167905519 cites W1992989737 @default.
- W2167905519 cites W2005652304 @default.
- W2167905519 cites W2008156174 @default.
- W2167905519 cites W2008201324 @default.
- W2167905519 cites W2009833394 @default.
- W2167905519 cites W2010230693 @default.
- W2167905519 cites W2010402674 @default.
- W2167905519 cites W2014355239 @default.
- W2167905519 cites W2014540773 @default.
- W2167905519 cites W2021292600 @default.
- W2167905519 cites W2023316520 @default.
- W2167905519 cites W2023734494 @default.
- W2167905519 cites W2026619286 @default.
- W2167905519 cites W2026696795 @default.
- W2167905519 cites W2029713109 @default.
- W2167905519 cites W2032177799 @default.
- W2167905519 cites W2032208151 @default.
- W2167905519 cites W2033003961 @default.
- W2167905519 cites W2034443606 @default.
- W2167905519 cites W2035792371 @default.
- W2167905519 cites W2036691108 @default.
- W2167905519 cites W2041207941 @default.
- W2167905519 cites W2047340605 @default.
- W2167905519 cites W2052655524 @default.
- W2167905519 cites W2053689957 @default.
- W2167905519 cites W2053961392 @default.
- W2167905519 cites W2057565196 @default.
- W2167905519 cites W2059097951 @default.
- W2167905519 cites W2061828581 @default.
- W2167905519 cites W2065094079 @default.
- W2167905519 cites W2066248857 @default.
- W2167905519 cites W2069673779 @default.
- W2167905519 cites W2070312499 @default.
- W2167905519 cites W2073004429 @default.
- W2167905519 cites W2073440202 @default.
- W2167905519 cites W2075650547 @default.
- W2167905519 cites W2077679777 @default.
- W2167905519 cites W2079029980 @default.
- W2167905519 cites W2087866447 @default.
- W2167905519 cites W2093960552 @default.
- W2167905519 cites W2099067892 @default.
- W2167905519 cites W2103248466 @default.
- W2167905519 cites W2105097410 @default.
- W2167905519 cites W2105494575 @default.
- W2167905519 cites W2107277218 @default.
- W2167905519 cites W2108610913 @default.
- W2167905519 cites W2115039568 @default.
- W2167905519 cites W2116848628 @default.
- W2167905519 cites W2120893200 @default.
- W2167905519 cites W2121999864 @default.
- W2167905519 cites W2126789399 @default.
- W2167905519 cites W2126824096 @default.
- W2167905519 cites W2128343787 @default.
- W2167905519 cites W2132619798 @default.
- W2167905519 cites W2132755552 @default.
- W2167905519 cites W2132849597 @default.
- W2167905519 cites W2139610636 @default.
- W2167905519 cites W2143027433 @default.
- W2167905519 cites W2143417330 @default.
- W2167905519 cites W2143464284 @default.
- W2167905519 cites W2146264275 @default.
- W2167905519 cites W2147335276 @default.
- W2167905519 cites W2153525031 @default.