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• W2167908880 abstract "This study demonstrates that CD4(+) T cells specific for an altered self-antigen differentiate to T cells secreting transforming growth factor (TGF)-beta1. In this study, we utilized mice expressing an altered peptide ligand containing a single amino acid substitution of moth cytochrome c 88-103 peptide. In these mice, antigen-specific T cells escaping thymic negative selection differentiated into T cells with an effector/memory phenotype, CD44(high), CD45RB(low), CD62L(-) and CD25(intermediate). The expression of CD25 and high levels of CD44 was initiated in the thymus during the development from CD4(+)CD8(+) to CD4(+); a large proportion of maturing CD4(+) thymocytes expressed both CD25 and high levels of CD44. Upon antigen stimulation, CD4(+) T cells derived from these mice did not proliferate or secrete IL-2, but secreted TGF-beta1. Neutralizing antibodies to TGF-beta1 reversed the impaired proliferative responses to the antigen, suggesting that TGF-beta1 secreted from these T cells negatively regulates T cell responses." @default.
• W2167908880 created "2016-06-24" @default.
• W2167908880 creator A5012121276 @default.
• W2167908880 creator A5032808906 @default.
• W2167908880 creator A5037803557 @default.
• W2167908880 date "2002-08-01" @default.
• W2167908880 modified "2023-09-23" @default.
• W2167908880 title "Development of CD25+ T cells secreting transforming growth factor-beta1 by altered peptide ligands expressed as self-antigens" @default.
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• W2167908880 doi "https://doi.org/10.1093/intimm/dxf061" @default.
• W2167908880 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12147622" @default.
• W2167908880 hasPublicationYear "2002" @default.
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