FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2167919759> ?p ?o ?g. }

• W2167919759 endingPage "334" @default.
• W2167919759 startingPage "326" @default.
• W2167919759 abstract "Excessive trans-fatty acids (TFA) consumption has been thought to be a risk factor mainly for coronary artery diseases while less attention has been paid to liver disease. We aimed to clarify the impact of TFA-rich oil consumption on the hepatic pathophysiology compared to natural oil.Mice were fed either a low-fat (LF) or high-fat (HF) diet made of either natural oil as control (LF-C or HF-C) or partially hydrogenated oil, TFA-rich oil (LF-T or HF-T) for 24 weeks. We evaluated the liver and body weight, serological features, liver lipid content and composition, liver histology and hepatic lipid metabolism-related gene expression profile. In addition, primary cultures of mice Kupffer cells (KCs) were evaluated for cytokine secretion and phagocytotic ability after incubation in cis- or trans-fatty acid-containing medium.The HF-T-fed mice showed significant increases of the liver and body weights, plasma alanine-aminotransferase, free fatty acid and hepatic triglyceride content compared to the HF-C group, whereas the LF-T group did not differ from the LF-C group. HF-T-fed mice developed severe steatosis, along with increased lipogenic gene expression and hepatic TFA accumulation. KCs showed increased tumor necrosis factor secretion and attenuated phagocytotic ability in the TFA-containing medium compared to its cis-isomer.Excessive consumption of the TFA-rich oil up-regulated the lipogenic gene expression along with marked hepatic lipid accumulation. TFA might be pathogenic through causing severe steatosis and modulating the function of KCs. The quantity and composition of dietary lipids could be responsible for the pathogenesis of non-alcoholic steatohepatitis." @default.
• W2167919759 created "2016-06-24" @default.
• W2167919759 creator A5001917366 @default.
• W2167919759 creator A5008253697 @default.
• W2167919759 creator A5011099690 @default.
• W2167919759 creator A5012266636 @default.
• W2167919759 creator A5016185391 @default.
• W2167919759 creator A5021094575 @default.
• W2167919759 creator A5025276347 @default.
• W2167919759 creator A5029930183 @default.
• W2167919759 creator A5034409526 @default.
• W2167919759 creator A5061978183 @default.
• W2167919759 creator A5066151943 @default.
• W2167919759 creator A5069236780 @default.
• W2167919759 creator A5072119723 @default.
• W2167919759 creator A5081319821 @default.
• W2167919759 date "2010-08-01" @default.
• W2167919759 modified "2023-10-16" @default.
• W2167919759 title "Possible involvement and the mechanisms of excess trans-fatty acid consumption in severe NAFLD in mice" @default.
• W2167919759 cites W1915919669 @default.
• W2167919759 cites W1970403836 @default.
• W2167919759 cites W1985592156 @default.
• W2167919759 cites W1992864925 @default.
• W2167919759 cites W2001668931 @default.
• W2167919759 cites W2007083715 @default.
• W2167919759 cites W2017554448 @default.
• W2167919759 cites W2023122744 @default.
• W2167919759 cites W2026887934 @default.
• W2167919759 cites W2033408802 @default.
• W2167919759 cites W2036578487 @default.
• W2167919759 cites W2047257800 @default.
• W2167919759 cites W2048104183 @default.
• W2167919759 cites W2053307994 @default.
• W2167919759 cites W2067038570 @default.
• W2167919759 cites W2067740038 @default.
• W2167919759 cites W2075225033 @default.
• W2167919759 cites W2078391210 @default.
• W2167919759 cites W2092412521 @default.
• W2167919759 cites W2093824918 @default.
• W2167919759 cites W2098555833 @default.
• W2167919759 cites W2102785858 @default.
• W2167919759 cites W2116139705 @default.
• W2167919759 cites W2132710304 @default.
• W2167919759 cites W2138304200 @default.
• W2167919759 cites W2144178804 @default.
• W2167919759 cites W2158594746 @default.
• W2167919759 cites W2163837156 @default.
• W2167919759 cites W2166240308 @default.
• W2167919759 cites W2167909421 @default.
• W2167919759 cites W2168526937 @default.
• W2167919759 cites W2170941268 @default.
• W2167919759 cites W4211155688 @default.
• W2167919759 doi "https://doi.org/10.1016/j.jhep.2010.02.029" @default.
• W2167919759 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20462650" @default.
• W2167919759 hasPublicationYear "2010" @default.
• W2167919759 type Work @default.
• W2167919759 sameAs 2167919759 @default.
• W2167919759 citedByCount "79" @default.
• W2167919759 countsByYear W21679197592012 @default.
• W2167919759 countsByYear W21679197592013 @default.
• W2167919759 countsByYear W21679197592014 @default.
• W2167919759 countsByYear W21679197592015 @default.
• W2167919759 countsByYear W21679197592016 @default.
• W2167919759 countsByYear W21679197592017 @default.
• W2167919759 countsByYear W21679197592018 @default.
• W2167919759 countsByYear W21679197592019 @default.
• W2167919759 countsByYear W21679197592020 @default.
• W2167919759 countsByYear W21679197592021 @default.
• W2167919759 countsByYear W21679197592022 @default.
• W2167919759 countsByYear W21679197592023 @default.
• W2167919759 crossrefType "journal-article" @default.
• W2167919759 hasAuthorship W2167919759A5001917366 @default.
• W2167919759 hasAuthorship W2167919759A5008253697 @default.
• W2167919759 hasAuthorship W2167919759A5011099690 @default.
• W2167919759 hasAuthorship W2167919759A5012266636 @default.
• W2167919759 hasAuthorship W2167919759A5016185391 @default.
• W2167919759 hasAuthorship W2167919759A5021094575 @default.
• W2167919759 hasAuthorship W2167919759A5025276347 @default.
• W2167919759 hasAuthorship W2167919759A5029930183 @default.
• W2167919759 hasAuthorship W2167919759A5034409526 @default.
• W2167919759 hasAuthorship W2167919759A5061978183 @default.
• W2167919759 hasAuthorship W2167919759A5066151943 @default.
• W2167919759 hasAuthorship W2167919759A5069236780 @default.
• W2167919759 hasAuthorship W2167919759A5072119723 @default.
• W2167919759 hasAuthorship W2167919759A5081319821 @default.
• W2167919759 hasConcept C126322002 @default.
• W2167919759 hasConcept C134018914 @default.
• W2167919759 hasConcept C17991360 @default.
• W2167919759 hasConcept C185592680 @default.
• W2167919759 hasConcept C2776175330 @default.
• W2167919759 hasConcept C2778163477 @default.
• W2167919759 hasConcept C2778772119 @default.
• W2167919759 hasConcept C2778913445 @default.
• W2167919759 hasConcept C2779134260 @default.
• W2167919759 hasConcept C4733338 @default.
• W2167919759 hasConcept C543025807 @default.
• W2167919759 hasConcept C55493867 @default.
• W2167919759 hasConcept C71924100 @default.

• next