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• W2167929412 abstract "<h3>Objective</h3>To empirically assess the concept that Alzheimer disease (AD) biomarkers significantly depart from normality in a temporally ordered manner.<h3>Design</h3>Validation sample.<h3>Setting</h3>Multisite, referral centers.<h3>Participants</h3>A total of 401 elderly participants in the Alzheimer's Disease Neuroimaging Initiative who were cognitively normal, who had mild cognitive impairment, or who had AD dementia. We compared the proportions of 3 AD biomarker values (the Aβ42 level in cerebrospinal fluid [CSF], the total tau level in CSF, and the hippocampal volume adjusted for intracranial volume [hereafter referred to as the adjusted hippocampal volume]) that were abnormal as cognitive impairment worsened. Cut points demarcating normal vs abnormal for each biomarker were established by maximizing diagnostic accuracy in independent autopsy samples.<h3>Main Outcome Measures</h3>Three AD biomarkers (ie, the CSF Aβ42 level, the CSF total tau level, and the adjusted hippocampal volume).<h3>Results</h3>Within each clinical group of the entire sample (n = 401), the CSF Aβ42 level was abnormal more often than was the CSF total tau level or the adjusted hippocampal volume. Among the 298 participants with both baseline and 12-month data, the proportion of participants with an abnormal Aβ42 level did not change from baseline to 12 months in any group. The proportion of participants with an abnormal total tau level increased from baseline to 12 months in cognitively normal participants (P = .05) but not in participants with mild cognitive impairment or AD dementia. For 209 participants with an abnormal CSF Aβ42 level at baseline, the percentage with an abnormal adjusted hippocampal volume but normal CSF total tau level increased from baseline to 12 months in participants with mild cognitive impairment. No change in the percentage of MCI participants with an abnormal total tau level was seen between baseline and 12 months.<h3>Conclusions</h3>A reduction in the CSF Aβ42 level denotes a pathophysiological process that significantly departs from normality (ie, becomes dynamic) early, whereas the CSF total tau level and the adjusted hippocampal volume are biomarkers of downstream pathophysiological processes. The CSF total tau level becomes dynamic before the adjusted hippocampal volume, but the hippocampal volume is more dynamic in the clinically symptomatic mild cognitive impairment and AD dementia phases of the disease than is the CSF total tau level." @default.
• W2167929412 created "2016-06-24" @default.
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• W2167929412 date "2011-12-01" @default.
• W2167929412 modified "2023-10-18" @default.
• W2167929412 title "Evidence for Ordering of Alzheimer Disease Biomarkers" @default.
• W2167929412 cites W1548995643 @default.
• W2167929412 cites W1974594322 @default.
• W2167929412 cites W1978684823 @default.
• W2167929412 cites W1979127061 @default.
• W2167929412 cites W1980529166 @default.
• W2167929412 cites W1983936885 @default.
• W2167929412 cites W1984009511 @default.
• W2167929412 cites W1984283611 @default.
• W2167929412 cites W1986400971 @default.
• W2167929412 cites W1987096559 @default.
• W2167929412 cites W1988370080 @default.
• W2167929412 cites W1990502495 @default.
• W2167929412 cites W1990752558 @default.
• W2167929412 cites W1993324100 @default.
• W2167929412 cites W1997301424 @default.
• W2167929412 cites W1998088268 @default.
• W2167929412 cites W2000406026 @default.
• W2167929412 cites W2003428745 @default.
• W2167929412 cites W2004293194 @default.
• W2167929412 cites W2005503435 @default.
• W2167929412 cites W2006247983 @default.
• W2167929412 cites W2006858320 @default.
• W2167929412 cites W2008152557 @default.
• W2167929412 cites W2008301592 @default.
• W2167929412 cites W2015896685 @default.
• W2167929412 cites W2022423664 @default.
• W2167929412 cites W2023484964 @default.
• W2167929412 cites W2024380030 @default.
• W2167929412 cites W2025627647 @default.
• W2167929412 cites W2025836081 @default.
• W2167929412 cites W2028590992 @default.
• W2167929412 cites W2031489026 @default.
• W2167929412 cites W2036162736 @default.
• W2167929412 cites W2038003677 @default.
• W2167929412 cites W2051489981 @default.
• W2167929412 cites W2054007740 @default.
• W2167929412 cites W2065338300 @default.
• W2167929412 cites W2068338689 @default.
• W2167929412 cites W2072361983 @default.
• W2167929412 cites W2078524519 @default.
• W2167929412 cites W2084617446 @default.
• W2167929412 cites W2085558649 @default.
• W2167929412 cites W2086978209 @default.
• W2167929412 cites W2087924155 @default.
• W2167929412 cites W2088129757 @default.
• W2167929412 cites W2089588548 @default.
• W2167929412 cites W2098176256 @default.
• W2167929412 cites W2098580427 @default.
• W2167929412 cites W2104954974 @default.
• W2167929412 cites W2111642028 @default.
• W2167929412 cites W2112691652 @default.
• W2167929412 cites W2113169386 @default.
• W2167929412 cites W2113518834 @default.
• W2167929412 cites W2114953476 @default.
• W2167929412 cites W2115017507 @default.
• W2167929412 cites W2115281122 @default.
• W2167929412 cites W2124114508 @default.
• W2167929412 cites W2126927216 @default.
• W2167929412 cites W2129497119 @default.
• W2167929412 cites W2131830246 @default.
• W2167929412 cites W2133719476 @default.
• W2167929412 cites W2134836371 @default.
• W2167929412 cites W2135624681 @default.
• W2167929412 cites W2136579519 @default.
• W2167929412 cites W2141854336 @default.
• W2167929412 cites W2144631174 @default.
• W2167929412 cites W2145450560 @default.
• W2167929412 cites W2146788881 @default.
• W2167929412 cites W2150231759 @default.
• W2167929412 cites W2155600573 @default.
• W2167929412 cites W2156024136 @default.
• W2167929412 cites W2156311276 @default.
• W2167929412 cites W2156326104 @default.
• W2167929412 cites W2157110881 @default.
• W2167929412 cites W2157848968 @default.
• W2167929412 cites W2158063156 @default.
• W2167929412 cites W2162936584 @default.
• W2167929412 cites W2167720733 @default.
• W2167929412 cites W2167834847 @default.
• W2167929412 cites W2167840686 @default.
• W2167929412 cites W2168884540 @default.
• W2167929412 cites W2171808809 @default.

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